D. Allan Butterfield

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  • The Alumni Association Endowed Professor of Biological Chemistry, 249 Chem-Phys, 859-257-3184
  • Director, Redox Metabolism Shared Resource Facility, Markey Cancer Center, 225 HSRB, 859-323-0476
  • Faculty, Sanders-Brown Center on Aging
  • Faculty Associate, Spinal Cord and Brain Injury Research Center
  • Associate Vice President for Research
  • Biological
  • Chemistry
249 Chemistry-Physics Building
859-257-3184 (office), 859-323-9985 (fax)
Education

Ph.D. Duke University, 1974
NIH Postdoctoral Fellow, Neuroscience, Duke University School of Medicine, 1974-1975

Research

The Butterfield laboratory studies free radical oxidative stress in aging and age-related neurodegenerative disorders, particularly Alzheimer's disease (AD). We discovered in AD brain that such oxidative stress is manifested  by protein oxidation, lipid peroxidation, reactive oxygen species (ROS) production, mitochondrial dysfunction, and functional impairment of key transmembrane transport proteins, among many others. Our laboratory studies these and other aspects of oxidative stress in brain membranes using a variety of techniques, including immunochemical, metabolomic, and proteomics methods. Our group first described how oxidative stress associated with amyloid  β-peptide, a 42-amino acid peptide deposited in AD brains, leads to neurotoxicity and how various antioxidants can modulate or prevent this oxidative stress and neuronal death. Insight into the molecular basis for and potential therapeutic interventions in aging and age-related neurodegenerative disorders is envisaged from our research. Recent research has emphasized the close connection between Type 2 diabetes mellitus and development of AD.  We found that brain from subjects with AD and for the first time in arguably AD’s earlier form, Mild Cognitive Impairment (MCI), strong evidence of insulin resistance, which contributes to the metabolic changes in brain well known in AD.

Our laboratory pioneered the techniques of redox proteomics (see figure below) to identify oxidatively modified brain proteins in subjects with AD and MCI. Proteins identified have provided new insights into molecular processes involved in mechanisms of neuronal death in and progression of AD.

Processes involved in redox proteomics, which is used to identify oxidatively modified brain proteins in Alzheimer's disease and other neurodegenerative disorders.

In a second area of research, the Butterfield laboratory discovered a mechanism for chemotherapy induced cognitive impairment (CICI), which lowers the quality of life for up to 70 percent of the currently 14 million cancer survivors in the USA.  Diminished executive functioning, inability to multitask, and slowness in mental processing, called “chemobrain” by patients, often are complaints described by persons with CICI.  Metabolic analyses using Seahorse technology and MS-based methods suggest mitochondrial dysfunction and apoptosis in brain following chemotherapy involving ROS associated chemotherapeutic agents, even though these agents do not cross the blood-brain barrier. We found an important inflammatory cytokine is elevated in plasma, and this harmful molecule does cross the BBB to initiate a series of harmful biochemical processes in brain.  Highly innovative studies using a variety of biochemical and chemical techniques are shedding light on how to prevent CICI, with the strong possibility that the quality of life of cancer survivors will be enhanced.

Graduate Training

Biophysical Chemistry and Neurochemistry

PubMed Publications*: 
  • Butterfield, DA ;Halliwell, B "Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease." Nature reviews. Neuroscience 20, 3 (2019): 148-160. Details. Full text
  • Salameh, TS ;Mortell, WG ;Logsdon, AF ;Butterfield, DA ;Banks, WA "Disruption of the hippocampal and hypothalamic blood-brain barrier in a diet-induced obese model of type II diabetes: prevention and treatment by the mitochondrial carbonic anhydrase inhibitor, topiramate." Fluids and barriers of the CNS 16, 1 (2019): 1. Details. Full text
  • Lanzillotta, C ;Di Domenico, F.;Perluigi, M.;Butterfield, DA "Targeting Mitochondria in Alzheimer Disease: Rationale and Perspectives." CNS drugs 33, 10 (2019): 957-969. Details. Full text
  • Ren, X ;Keeney, JTR ;Miriyala, S.;Noel, T.;Powell, DK ;Chaiswing, L ;Bondada, S.;St Clair, DK ;Butterfield, DA "The triangle of death of neurons: Oxidative damage, mitochondrial dysfunction, and loss of choline-containing biomolecules in brains of mice treated with doxorubicin. Advanced insights into mechanisms of chemotherapy induced cognitive impairment..." Free radical biology & medicine 134, (2019): 1-8. Details. Full text
  • Ren, X ;Hinchie, A ;Swomley, A ;Powell, DK ;Butterfield, DA "Profiles of brain oxidative damage, ventricular alterations, and neurochemical metabolites in the striatum of PINK1 knockout rats as functions of age and gender: Relevance to Parkinson disease." Free radical biology & medicine 143, (2019): 146-152. Details. Full text
  • Gedaly, R ;De Stefano, F ;Turcios, L ;Hill, M ;Hidalgo, G ;Mitov, MI ;Alstott, MC ;Butterfield, DA ;Mitchell, HC ;Hart, J ;Al-Attar, A.;Jennings, CD ;Marti, F "mTOR Inhibitor Everolimus in Regulatory T Cell Expansion for Clinical Application in Transplantation." Transplantation 103, 4 (2019): 705-715. Details. Full text
  • Yarana, C ;Thompson, H ;Chaiswing, L ;Butterfield, DA ;Weiss, H ;Bondada, S.;Alhakeem, S ;Sukati, S ;St Clair, DK "Extracellular vesicle-mediated macrophage activation: An insight into the mechanism of thioredoxin-mediated immune activation." Redox biology 26, (2019): 101237. Details. Full text
  • Butterfield, DA "Phosphoproteomics of Alzheimer disease brain: Insights into altered brain protein regulation of critical neuronal functions and their contributions to subsequent cognitive loss." Biochimica et biophysica acta. Molecular basis of disease 1865, 8 (2019): 2031-2039. Details. Full text
  • Liu, L.;Qi, L ;Knifley, T ;Piecoro, DW ;Rychahou, P ;Liu, J.;Mitov, MI ;Martin, J ;Wang, C.;Wu, J.;Weiss, HL ;Butterfield, DA ;Evers, BM ;O'Connor, KL ;Chen, M. "S100A4 alters metabolism and promotes invasion of lung cancer cells by up-regulating mitochondrial complex I protein NDUFS2." The Journal of biological chemistry 294, 18 (2019): 7516-7527. Details. Full text
  • Butterfield, DA ;Boyd-Kimball, D "Redox proteomics and amyloid β-peptide: insights into Alzheimer disease." Journal of neurochemistry 151, 4 (2019): 459-487. Details. Full text
  • Di Domenico, F.;Tramutola, A ;Barone, E.;Lanzillotta, C ;Defever, O ;Arena, A ;Zuliani, I ;Foppoli, C.;Iavarone, F ;Vincenzoni, F ;Castagnola, M ;Butterfield, DA ;Perluigi, M. "Restoration of aberrant mTOR signaling by intranasal rapamycin reduces oxidative damage: Focus on HNE-modified proteins in a mouse model of down syndrome." Redox biology 23, (2019): 101162. Details. Full text
  • Ren, X ;Boriero, D ;Chaiswing, L ;Bondada, S.;St Clair, DK ;Butterfield, DA "Plausible biochemical mechanisms of chemotherapy-induced cognitive impairment ("chemobrain"), a condition that significantly impairs the quality of life of many cancer survivors." Biochimica et biophysica acta. Molecular basis of disease 1865, 6 (2019): 1088-1097. Details. Full text
  • Barone, E.;Tramutola, A ;Triani, F ;Calcagnini, S ;Di Domenico, F.;Ripoli, C ;Gaetani, S ;Grassi, C ;Butterfield, DA ;Cassano, T ;Perluigi, M. "Biliverdin Reductase-A Mediates the Beneficial Effects of Intranasal Insulin in Alzheimer Disease." Molecular neurobiology 56, 4 (2019): 2922-2943. Details. Full text
  • Sharma, N.;Tramutola, A ;Lanzillotta, C ;Arena, A ;Blarzino, C ;Cassano, T ;Butterfield, DA ;Di Domenico, F.;Perluigi, M.;Barone, E. "Loss of biliverdin reductase-A favors Tau hyper-phosphorylation in Alzheimer's disease." Neurobiology of disease 125, (2019): 176-189. Details. Full text
  • Tramutola, A ;Triani, F ;Di Domenico, F.;Barone, E.;Cai, J.;Klein, JB ;Perluigi, M.;Butterfield, DA "Poly-ubiquitin profile in Alzheimer disease brain." Neurobiology of disease 118, (2018): 129-141. Details. Full text
  • Di Domenico, F.;Tramutola, A ;Foppoli, C.;Head, E.;Perluigi, M.;Butterfield, DA "mTOR in Down syndrome: Role in Aß and tau neuropathology and transition to Alzheimer disease-like dementia." Free radical biology & medicine 114, (2018): 94-101. Details. Full text
  • Triani, F ;Tramutola, A ;Di Domenico, F.;Sharma, N.;Butterfield, DA ;Head, E.;Perluigi, M.;Barone, E. "Biliverdin reductase-A impairment links brain insulin resistance with increased Aβ production in an animal model of aging: Implications for Alzheimer disease." Biochimica et biophysica acta. Molecular basis of disease 1864, 10 (2018): 3181-3194. Details. Full text
  • Barone, E.;Arena, A ;Head, E.;Butterfield, DA ;Perluigi, M. "Disturbance of redox homeostasis in Down Syndrome: Role of iron dysmetabolism." Free radical biology & medicine 114, (2018): 84-93. Details. Full text
  • Tramutola, A ;Abate, G ;Lanzillotta, C ;Triani, F ;Barone, E.;Iavarone, F ;Vincenzoni, F ;Castagnola, M ;Marziano, M ;Memo, M ;Garrafa, E ;Butterfield, DA ;Perluigi, M.;Di Domenico, F.;Uberti, D "Protein nitration profile of CD3<sup>+</sup> lymphocytes from Alzheimer disease patients: Novel hints on immunosenescence and biomarker detection." Free radical biology & medicine 129, (2018): 430-439. Details. Full text
  • Keeney, JTR ;Ren, X ;Warrier, G.;Noel, T.;Powell, DK ;Brelsfoard, JM ;Sultana, R.;Saatman, KE ;Clair, DKS ;Butterfield, DA "Doxorubicin-induced elevated oxidative stress and neurochemical alterations in brain and cognitive decline: protection by MESNA and insights into mechanisms of chemotherapy-induced cognitive impairment ("chemobrain")." Oncotarget 9, 54 (2018): 30324-30339. Details. Full text
  • Butterfield, DA ;Perluigi, M. "Down syndrome: From development to adult life to Alzheimer disease." Free radical biology & medicine 114, (2018): 1-2. Details. Full text
  • Yarana, C ;Carroll, D ;Chen, J.;Chaiswing, L ;Zhao, Y.;Noel, T.;Alstott, M ;Bae, Y ;Dressler, EV ;Moscow, JA ;Butterfield, DA ;Zhu, H.;St Clair, DK "Extracellular Vesicles Released by Cardiomyocytes in a Doxorubicin-Induced Cardiac Injury Mouse Model Contain Protein Biomarkers of Early Cardiac Injury." Clinical cancer research : an official journal of the American Association for Cancer Research 24, 7 (2018): 1644-1653. Details. Full text
  • Tramutola, A ;Sharma, N.;Barone, E.;Lanzillotta, C ;Castellani, A ;Iavarone, F ;Vincenzoni, F ;Castagnola, M ;Butterfield, DA ;Gaetani, S ;Cassano, T ;Perluigi, M.;Di Domenico, F. "Proteomic identification of altered protein O-GlcNAcylation in a triple transgenic mouse model of Alzheimer's disease." Biochimica et biophysica acta. Molecular basis of disease 1864, 10 (2018): 3309-3321. Details. Full text
  • Arndt, DA ;Oostveen, EK ;Triplett, J ;Butterfield, DA ;Tsyusko, OV ;Collin, B ;Starnes, DL ;Cai, J.;Klein, JB ;Nass, R ;Unrine, JM "The role of charge in the toxicity of polymer-coated cerium oxide nanomaterials to Caenorhabditis elegans." Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 201, (2017): 1-10. Details. Full text
  • Butterfield, DA ;Perluigi, M. "Redox Proteomics: A Key Tool for New Insights into Protein Modification with Relevance to Disease." Antioxidants & redox signaling 26, 7 (2017): 277-279. Details. Full text
  • Thomas, TC ;Beitchman, JA ;Pomerleau, F ;Noel, T.;Jungsuwadee, P.;Butterfield, DA ;Clair, DKS ;Vore, M.;Gerhardt, GA "Acute treatment with doxorubicin affects glutamate neurotransmission in the mouse frontal cortex and hippocampus." Brain research 1672, (2017): 10-17. Details. Full text
  • Vilchez, V ;Turcios, L ;Butterfield, DA ;Mitov, MI ;Coquillard, CL ;Brandon, JA ;Cornea, V ;Gedaly, R ;Marti, F "Evidence of the immunomodulatory role of dual PI3K/mTOR inhibitors in transplantation: an experimental study in mice." Transplant international : official journal of the European Society for Organ Transplantation 30, 10 (2017): 1061-1074. Details. Full text
  • Palmieri, EM ;Menga, A ;Lebrun, A ;Hooper, DC ;Butterfield, DA ;Mazzone, M ;Castegna, A "Blockade of Glutamine Synthetase Enhances Inflammatory Response in Microglial Cells." Antioxidants & redox signaling 26, 8 (2017): 351-363. Details. Full text
  • Zhang, J.;Butterfield, DA "Oxidative stress and neurodegeneration." Brain research bulletin 133, (2017): 1-3. Details. Full text
  • Di Domenico, F.;Tramutola, A ;Butterfield, DA "Role of 4-hydroxy-2-nonenal (HNE) in the pathogenesis of alzheimer disease and other selected age-related neurodegenerative disorders." Free radical biology & medicine 111, (2017): 253-261. Details. Full text
  • Mitov, MI ;Harris, JW ;Alstott, MC ;Zaytseva, YY ;Evers, BM ;Butterfield, DA "Temperature induces significant changes in both glycolytic reserve and mitochondrial spare respiratory capacity in colorectal cancer cell lines." Experimental cell research 354, 2 (2017): 112-121. Details. Full text
  • Tramutola, A ;Lanzillotta, C ;Perluigi, M.;Butterfield, DA "Oxidative stress, protein modification and Alzheimer disease." Brain research bulletin 133, (2017): 88-96. Details. Full text
  • Di Domenico, F.;Barone, E.;Perluigi, M.;Butterfield, DA "The Triangle of Death in Alzheimer's Disease Brain: The Aberrant Cross-Talk Among Energy Metabolism, Mammalian Target of Rapamycin Signaling, and Protein Homeostasis Revealed by Redox Proteomics." Antioxidants & redox signaling 26, 8 (2017): 364-387. Details. Full text
  • Turcios, L ;Vilchez, V ;Acosta, LF ;Poyil, P ;Butterfield, DA ;Mitov, M ;Marti, F ;Gedaly, R "Sorafenib and FH535 in combination act synergistically on hepatocellular carcinoma by targeting cell bioenergetics and mitochondrial function." Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 49, 6 (2017): 697-704. Details. Full text
  • Tramutola, A ;Arena, A ;Cini, C.;Butterfield, DA ;Barone, E. "Modulation of GLP-1 signaling as a novel therapeutic approach in the treatment of Alzheimer's disease pathology." Expert review of neurotherapeutics 17, 1 (2017): 59-75. Details. Full text
  • Ren, X ;St Clair, DK ;Butterfield, DA "Dysregulation of cytokine mediated chemotherapy induced cognitive impairment." Pharmacological research 117, (2017): 267-273. Details. Full text
  • Tramutola, A ;Di Domenico, F.;Barone, E.;Arena, A ;Giorgi, A.;di Francesco, L ;Schininà, ME ;Coccia, R.;Head, E.;Butterfield, DA ;Perluigi, M. "Polyubiquitinylation Profile in Down Syndrome Brain Before and After the Development of Alzheimer Neuropathology." Antioxidants & redox signaling 26, 7 (2017): 280-298. Details. Full text
  • Swomley, AM ;Triplett, JC ;Keeney, JT ;Warrier, G.;Pearson, KJ ;Mattison, JA ;de Cabo, R ;Cai, J.;Klein, JB ;Butterfield, DA "Comparative proteomic analyses of the parietal lobe from rhesus monkeys fed a high-fat/sugar diet with and without resveratrol supplementation, relative to a healthy diet: Insights into the roles of unhealthy diets and resveratrol on function." The Journal of nutritional biochemistry 39, (2017): 169-179. Details. Full text
  • Barone, E.;Head, E.;Butterfield, DA ;Perluigi, M. "HNE-modified proteins in Down syndrome: Involvement in development of Alzheimer disease neuropathology." Free radical biology & medicine 111, (2017): 262-269. Details. Full text
  • Butterfield, DA ;Reed, TT "Lipid peroxidation and tyrosine nitration in traumatic brain injury: Insights into secondary injury from redox proteomics." Proteomics. Clinical applications 10, 12 (2016): 1191-1204. Details. Full text
  • Farr, SA ;Niehoff, ML ;Ceddia, MA ;Herrlinger, KA ;Lewis, BJ ;Feng, S ;Welleford, A ;Butterfield, DA ;Morley, JE "Effect of botanical extracts containing carnosic acid or rosmarinic acid on learning and memory in SAMP8 mice." Physiology & behavior 165, (2016): 328-38. Details. Full text
  • Barone, E.;Di Domenico, F.;Cassano, T ;Arena, A ;Tramutola, A ;Lavecchia, MA ;Coccia, R.;Butterfield, DA ;Perluigi, M. "Impairment of biliverdin reductase-A promotes brain insulin resistance in Alzheimer disease: A new paradigm." Free radical biology & medicine 91, (2016): 127-42. Details. Full text
  • Gupta, P ;Jordan, CT ;Mitov, MI ;Butterfield, DA ;Hilt, JZ ;Dziubla, TD "Controlled curcumin release via conjugation into PBAE nanogels enhances mitochondrial protection against oxidative stress." International journal of pharmaceutics 511, 2 (2016): 1012-21. Details. Full text
  • Di Domenico, F.;Pupo, G ;Giraldo, E ;Badìa, MC ;Monllor, P ;Lloret, A ;Schininà, ME ;Giorgi, A.;Cini, C.;Tramutola, A ;Butterfield, DA ;Viña, J ;Perluigi, M. "Oxidative signature of cerebrospinal fluid from mild cognitive impairment and Alzheimer disease patients." Free radical biology & medicine 91, (2016): 1-9. Details. Full text
  • Miriyala, S.;Thippakorn, C ;Chaiswing, L ;Xu, Y.;Noel, T.;Tovmasyan, A ;Batinic-Haberle, I ;Kooi, CW Vander;Chi, W ;Latif, AA ;Panchatcharam, M ;Prachayasittikul, V ;Butterfield, DA ;Vore, M.;Moscow, J ;St Clair, DK "Novel role of 4-hydroxy-2-nonenal in AIFm2-mediated mitochondrial stress signaling." Free radical biology & medicine 91, (2016): 68-80. Details. Full text
  • Perluigi, M.;Barone, E.;Di Domenico, F.;Butterfield, DA "Aberrant protein phosphorylation in Alzheimer disease brain disturbs pro-survival and cell death pathways." Biochimica et biophysica acta 1862, 10 (2016): 1871-82. Details. Full text
  • Lin, AL ;Butterfield, DA ;Richardson, A. "mTOR: Alzheimer's disease prevention for APOE4 carriers." Oncotarget 7, 29 (2016): 44873-44874. Details. Full text
  • Triplett, JC ;Swomley, AM ;Kirk, J.;Grimes, KM ;Lewis, KN ;Orr, ME ;Rodriguez, KA ;Cai, J.;Klein, JB ;Buffenstein, R ;Butterfield, DA "Reaching Out to Send a Message: Proteins Associated with Neurite Outgrowth and Neurotransmission are Altered with Age in the Long-Lived Naked Mole-Rat." Neurochemical research 41, 7 (2016): 1625-34. Details. Full text
  • Swomley, AM ;Butterfield, DA "Oxidative stress in Alzheimer disease and mild cognitive impairment: evidence from human data provided by redox proteomics." Archives of toxicology 89, 10 (2015): 1669-80. Details. Full text
  • Perluigi, M.;Di Domenico, F.;Butterfield, DA "mTOR signaling in aging and neurodegeneration: At the crossroad between metabolism dysfunction and impairment of autophagy." Neurobiology of disease 84, (2015): 39-49. Details. Full text
  • Zaytseva, YY ;Harris, JW ;Mitov, MI ;Kim, JT ;Butterfield, DA ;Lee, EY ;Weiss, HL ;Gao, T ;Evers, BM "Increased expression of fatty acid synthase provides a survival advantage to colorectal cancer cells via upregulation of cellular respiration." Oncotarget 6, 22 (2015): 18891-904. Details. Full text
  • Barone, E.;Butterfield, DA "Insulin resistance in Alzheimer disease: Is heme oxygenase-1 an Achille's heel?" Neurobiology of disease 84, (2015): 69-77. Details. Full text
  • Triplett, JC ;Swomley, A ;Kirk, J.;Lewis, K ;Orr, M ;Rodriguez, K ;Cai, J.;Klein, JB ;Buffenstein, R ;Butterfield, DA "Metabolic clues to salubrious longevity in the brain of the longest-lived rodent: the naked mole-rat." Journal of neurochemistry 134, 3 (2015): 538-50. Details. Full text
  • Triplett, JC ;Zhang, Z.;Sultana, R.;Cai, J.;Klein, JB ;Büeler, H ;Butterfield, DA "Quantitative expression proteomics and phosphoproteomics profile of brain from PINK1 knockout mice: insights into mechanisms of familial Parkinson's disease." Journal of neurochemistry 133, 5 (2015): 750-65. Details. Full text
  • Chen, CH ;Li, W.;Sultana, R.;You, MH ;Kondo, A ;Shahpasand, K ;Kim, BM ;Luo, ML ;Nechama, M ;Lin, YM ;Yao, Y.;Lee, TH ;Zhou, XZ ;Swomley, AM ;Butterfield, DA ;Zhang, Y.;Lu, KP "Pin1 cysteine-113 oxidation inhibits its catalytic activity and cellular function in Alzheimer's disease." Neurobiology of disease 76, (2015): 13-23. Details. Full text
  • Barone, E.;Cenini, G.;Di Domenico, F.;Noel, T.;Wang, C.;Perluigi, M.;St Clair, DK ;Butterfield, DA "Basal brain oxidative and nitrative stress levels are finely regulated by the interplay between superoxide dismutase 2 and p53." Journal of neuroscience research 93, 11 (2015): 1728-39. Details. Full text
  • Triplett, JC ;Tramutola, A ;Swomley, A ;Kirk, J.;Grimes, K ;Lewis, K ;Orr, M ;Rodriguez, K ;Cai, J.;Klein, JB ;Perluigi, M.;Buffenstein, R ;Butterfield, DA "Age-related changes in the proteostasis network in the brain of the naked mole-rat: Implications promoting healthy longevity." Biochimica et biophysica acta 1852, 10 Pt A (2015): 2213-24. Details. Full text
  • Keeney, JT ;Miriyala, S.;Noel, T.;Moscow, JA ;St Clair, DK ;Butterfield, DA "Superoxide induces protein oxidation in plasma and TNF-α elevation in macrophage culture: Insights into mechanisms of neurotoxicity following doxorubicin chemotherapy." Cancer letters 367, 2 (2015): 157-61. Details. Full text
  • Butterfield, DA "Redox signaling in neurodegeneration." Neurobiology of disease 84, (2015): 1-3. Details. Full text
  • Keeney, JT ;Butterfield, DA "Vitamin D deficiency and Alzheimer disease: Common links." Neurobiology of disease 84, (2015): 84-98. Details. Full text
  • Swomley, AM ;Förster, S ;Keeney, JT ;Triplett, J ;Zhang, Z.;Sultana, R.;Butterfield, DA "Abeta, oxidative stress in Alzheimer disease: evidence based on proteomics studies." Biochimica et biophysica acta 1842, 8 (2014): 1248-57. Details. Full text
  • Förster, S ;Welleford, AS ;Triplett, JC ;Sultana, R.;Schmitz, B ;Butterfield, DA "Increased O-GlcNAc levels correlate with decreased O-GlcNAcase levels in Alzheimer disease brain." Biochimica et biophysica acta 1842, 9 (2014): 1333-9. Details. Full text
  • Perluigi, M.;Pupo, G ;Tramutola, A ;Cini, C.;Coccia, R.;Barone, E.;Head, E.;Butterfield, DA ;Di Domenico, F. "Neuropathological role of PI3K/Akt/mTOR axis in Down syndrome brain." Biochimica et biophysica acta 1842, 7 (2014): 1144-53. Details. Full text
  • Barone, E.;Di Domenico, F.;Mancuso, C.;Butterfield, DA "The Janus face of the heme oxygenase/biliverdin reductase system in Alzheimer disease: it's time for reconciliation." Neurobiology of disease 62, (2014): 144-59. Details. Full text
  • Di Domenico, F.;Pupo, G ;Tramutola, A ;Giorgi, A.;Schininà, ME ;Coccia, R.;Head, E.;Butterfield, DA ;Perluigi, M. "Redox proteomics analysis of HNE-modified proteins in Down syndrome brain: clues for understanding the development of Alzheimer disease." Free radical biology & medicine 71, (2014): 270-80. Details. Full text
  • Zhao, Y.;Miriyala, S.;Miao, L ;Mitov, M ;Schnell, D ;Dhar, SK ;Cai, J.;Klein, JB ;Sultana, R.;Butterfield, DA ;Vore, M.;Batinic-Haberle, I ;Bondada, S.;St Clair, DK "Redox proteomic identification of HNE-bound mitochondrial proteins in cardiac tissues reveals a systemic effect on energy metabolism after doxorubicin treatment." Free radical biology & medicine 72, (2014): 55-65. Details. Full text
  • Perluigi, M.;Swomley, AM ;Butterfield, DA "Redox proteomics and the dynamic molecular landscape of the aging brain." Ageing research reviews 13, (2014): 75-89. Details. Full text
  • Graham, UM ;Tseng, MT ;Jasinski, JB ;Yokel, RA ;Unrine, JM ;Davis, BH ;Dozier, AK ;Hardas, SS ;Sultana, R.;Grulke, EA ;Butterfield, DA "In Vivo Processing of Ceria Nanoparticles inside Liver: Impact on Free-Radical Scavenging Activity and Oxidative Stress." ChemPlusChem 79, 8 (2014): 1083-1088. Details.
  • Farr, SA ;Ripley, JL ;Sultana, R.;Zhang, Z.;Niehoff, ML ;Platt, TL ;Murphy, MP ;Morley, JE ;Kumar, V.;Butterfield, DA "Antisense oligonucleotide against GSK-3β in brain of SAMP8 mice improves learning and memory and decreases oxidative stress: Involvement of transcription factor Nrf2 and implications for Alzheimer disease." Free radical biology & medicine 67, (2014): 387-95. Details. Full text
  • Butterfield, DA ;Di Domenico, F.;Swomley, AM ;Head, E.;Perluigi, M. "Redox proteomics analysis to decipher the neurobiology of Alzheimer-like neurodegeneration: overlaps in Down's syndrome and Alzheimer's disease brain." The Biochemical journal 463, 2 (2014): 177-89. Details. Full text
  • Ulatowski, L ;Parker, R.;Warrier, G.;Sultana, R.;Butterfield, DA ;Manor, D "Vitamin E is essential for Purkinje neuron integrity." Neuroscience 260, (2014): 120-9. Details. Full text
  • Cenini, G.;Fiorini, A.;Sultana, R.;Perluigi, M.;Cai, J.;Klein, JB ;Head, E.;Butterfield, DA "An investigation of the molecular mechanisms engaged before and after the development of Alzheimer disease neuropathology in Down syndrome: a proteomics approach." Free radical biology & medicine 76, (2014): 89-95. Details. Full text
  • Butterfield, DA "The 2013 SFRBM discovery award: selected discoveries from the butterfield laboratory of oxidative stress and its sequela in brain in cognitive disorders exemplified by Alzheimer disease and chemotherapy induced cognitive impairment." Free radical biology & medicine 74, (2014): 157-74. Details. Full text
  • Barone, E.;Di Domenico, F.;Butterfield, DA "Statins more than cholesterol lowering agents in Alzheimer disease: their pleiotropic functions as potential therapeutic targets." Biochemical pharmacology 88, 4 (2014): 605-16. Details. Full text
  • Butterfield, DA ;Di Domenico, F.;Barone, E. "Elevated risk of type 2 diabetes for development of Alzheimer disease: a key role for oxidative stress in brain." Biochimica et biophysica acta 1842, 9 (2014): 1693-706. Details. Full text
  • Tseng, MT ;Fu, Q ;Lor, K ;Fernandez-Botran, GR ;Deng, ZB ;Graham, U ;Butterfield, DA ;Grulke, EA ;Yokel, RA "Persistent hepatic structural alterations following nanoceria vascular infusion in the rat." Toxicologic pathology 42, 6 (2014): 984-96. Details. Full text
  • Keeney, JT ;Swomley, AM ;Förster, S ;Harris, JL ;Sultana, R.;Butterfield, DA "Apolipoprotein A-I: insights from redox proteomics for its role in neurodegeneration." Proteomics. Clinical applications 7, 1-2 (2013): 109-22. Details. Full text
  • Makani, V ;Sultana, R.;Sie, KS ;Orjiako, D ;Tatangelo, M ;Dowling, A ;Cai, J.;Pierce, W.;Butterfield, DA ;Hill, J ;Park, J. "Annexin A1 complex mediates oxytocin vesicle transport." Journal of neuroendocrinology 25, 12 (2013): 1241-1254. Details. Full text
  • Sultana, R.;Baglioni, M.;Cecchetti, R.;Cai, J.;Klein, JB ;Bastiani, P ;Ruggiero, C ;Mecocci, P.;Butterfield, DA "Lymphocyte mitochondria: toward identification of peripheral biomarkers in the progression of Alzheimer disease." Free radical biology & medicine 65, (2013): 595-606. Details. Full text
  • Keeney, JTR ;Förster, S ;Sultana, R.;Brewer, LD ;Latimer, CS ;Cai, J.;Klein, JB ;Porter, NM ;Butterfield, DA "Dietary vitamin D deficiency in rats from middle to old age leads to elevated tyrosine nitration and proteomics changes in levels of key proteins in brain: implications for low vitamin D-dependent age-related cognitive decline." Free radical biology & medicine 65, (2013): 324-334. Details. Full text
  • Fiorini, A.;Sultana, R.;Förster, S ;Perluigi, M.;Cenini, G.;Cini, C.;Cai, J.;Klein, JB ;Farr, SA ;Niehoff, ML ;Morley, JE ;Kumar, VB ;Butterfield, DA "Antisense directed against PS-1 gene decreases brain oxidative markers in aged senescence accelerated mice (SAMP8) and reverses learning and memory impairment: a proteomics study." Free radical biology & medicine 65, (2013): 1-14. Details. Full text
  • Butterfield, DA ;Swomley, AM ;Sultana, R. "Amyloid β-peptide (1-42)-induced oxidative stress in Alzheimer disease: importance in disease pathogenesis and progression." Antioxidants & redox signaling 19, 8 (2013): 823-35. Details. Full text
  • Sultana, R.;Perluigi, M.;Butterfield, DA "Lipid peroxidation triggers neurodegeneration: a redox proteomics view into the Alzheimer disease brain." Free radical biology & medicine 62, (2013): 157-169. Details. Full text
  • Jungsuwadee, P.;Zhao, T.;Stolarczyk, EI ;Paumi, CM ;Butterfield, DA ;St Clair, DK ;Vore, M. "The G671V variant of MRP1/ABCC1 links doxorubicin-induced acute cardiac toxicity to disposition of the glutathione conjugate of 4-hydroxy-2-trans-nonenal." Pharmacogenetics and genomics 22, 4 (2012): 273-84. Details. Full text
  • Tsyusko, OV ;Hardas, SS ;Shoults-Wilson, WA ;Starnes, CP ;Joice, G ;Butterfield, DA ;Unrine, JM "Short-term molecular-level effects of silver nanoparticle exposure on the earthworm, Eisenia fetida." Environmental pollution (Barking, Essex : 1987) 171, (2012): 249-55. Details. Full text
  • Barone, E.;Cenini, G.;Sultana, R.;Di Domenico, F.;Fiorini, A.;Perluigi, M.;Noel, T.;Wang, C.;Mancuso, C.;St Clair, DK ;Butterfield, DA "Lack of p53 decreases basal oxidative stress levels in the brain through upregulation of thioredoxin-1, biliverdin reductase-A, manganese superoxide dismutase, and nuclear factor kappa-B." Antioxidants & redox signaling 16, 12 (2012): 1407-20. Details. Full text
  • Hardas, SS ;Sultana, R.;Warrier, G.;Dan, M ;Florence, RL ;Wu, P ;Grulke, EA ;Tseng, MT ;Unrine, JM ;Graham, UM ;Yokel, RA ;Butterfield, DA "Rat brain pro-oxidant effects of peripherally administered 5 nm ceria 30 days after exposure." Neurotoxicology 33, 5 (2012): 1147-55. Details. Full text
  • Butterfield, DA ;Barone, E.;Di Domenico, F.;Cenini, G.;Sultana, R.;Murphy, MP ;Mancuso, C.;Head, E. "Atorvastatin treatment in a dog preclinical model of Alzheimer's disease leads to up-regulation of haem oxygenase-1 and is associated with reduced oxidative stress in brain." The international journal of neuropsychopharmacology 15, 7 (2012): 981-7. Details. Full text
  • Butterfield, DA ;Perluigi, M.;Reed, T ;Muharib, T ;Hughes, CP ;Robinson, RA ;Sultana, R. "Redox proteomics in selected neurodegenerative disorders: from its infancy to future applications." Antioxidants & redox signaling 17, 11 (2012): 1610-55. Details. Full text
  • Keeney, JT ;Swomley, AM ;Harris, JL ;Fiorini, A.;Mitov, MI ;Perluigi, M.;Sultana, R.;Butterfield, DA "Cell cycle proteins in brain in mild cognitive impairment: insights into progression to Alzheimer disease." Neurotoxicity research 22, 3 (2012): 220-30. Details. Full text
  • Pocernich, CB ;Butterfield, DA "Elevation of glutathione as a therapeutic strategy in Alzheimer disease." Biochimica et biophysica acta 1822, 5 (2012): 625-30. Details. Full text
  • Sultana, R.;Robinson, RA ;Lange, MB ;Fiorini, A.;Galvan, V.;Fombonne, J.;Baker, A ;Gorostiza, O.;Zhang, J.;Cai, J.;Pierce, WM ;Bredesen, DE ;Butterfield, DA "Do proteomics analyses provide insights into reduced oxidative stress in the brain of an Alzheimer disease transgenic mouse model with an M631L amyloid precursor protein substitution and thereby the importance of amyloid-beta-resident methionine 35 in..." Antioxidants & redox signaling 17, 11 (2012): 1507-14. Details. Full text
  • Cenini, G.;Dowling, AL ;Beckett, TL ;Barone, E.;Mancuso, C.;Murphy, MP ;LeVine H, 3rd ;Lott, IT ;Schmitt, FA ;Butterfield, DA ;Head, E. "Association between frontal cortex oxidative damage and beta-amyloid as a function of age in Down syndrome." Biochimica et biophysica acta 1822, 2 (2012): 130-8. Details. Full text
  • Di Domenico, F.;Casalena, G ;Jia, J.;Sultana, R.;Barone, E.;Cai, J.;Pierce, WM ;Cini, C.;Mancuso, C.;Perluigi, M.;Davis, CM ;Alkayed, NJ ;Butterfield, DA "Sex differences in brain proteomes of neuron-specific STAT3-null mice after cerebral ischemia/reperfusion." Journal of neurochemistry 121, 4 (2012): 680-92. Details. Full text
  • Barone, E.;Mancuso, C.;Di Domenico, F.;Sultana, R.;Murphy, MP ;Head, E.;Butterfield, DA "Biliverdin reductase-A: a novel drug target for atorvastatin in a dog pre-clinical model of Alzheimer disease." Journal of neurochemistry 120, 1 (2012): 135-46. Details. Full text
  • Tseng, MT ;Lu, X ;Duan, X ;Hardas, SS ;Sultana, R.;Wu, P ;Unrine, JM ;Graham, U ;Butterfield, DA ;Grulke, EA ;Yokel, RA "Alteration of hepatic structure and oxidative stress induced by intravenous nanoceria." Toxicology and applied pharmacology 260, 2 (2012): 173-82. Details. Full text
  • Yokel, RA ;Au, TC ;MacPhail, R ;Hardas, SS ;Butterfield, DA ;Sultana, R.;Goodman, M ;Tseng, MT ;Dan, M ;Haghnazar, H ;Unrine, JM ;Graham, UM ;Wu, P ;Grulke, EA "Distribution, elimination, and biopersistence to 90 days of a systemically introduced 30 nm ceria-engineered nanomaterial in rats." Toxicological sciences : an official journal of the Society of Toxicology 127, 1 (2012): 256-68. Details. Full text
  • Di Domenico, F.;Sultana, R.;Ferree, A ;Smith, K ;Barone, E.;Perluigi, M.;Coccia, R.;Pierce, W.;Cai, J.;Mancuso, C.;Squillace, R ;Wiengele, M ;Dalle-Donne, I ;Wolozin, B ;Butterfield, DA "Redox proteomics analyses of the influence of co-expression of wild-type or mutated LRRK2 and Tau on C. elegans protein expression and oxidative modification: relevance to Parkinson disease." Antioxidants & redox signaling 17, 11 (2012): 1490-506. Details. Full text
  • Robinson, RA ;Joshi, G.;Huang, Q.;Sultana, R.;Baker, AS ;Cai, J.;Pierce, W.;St Clair, DK ;Markesbery, WR ;Butterfield, DA "Proteomic analysis of brain proteins in APP/PS-1 human double mutant knock-in mice with increasing amyloid β-peptide deposition: insights into the effects of in vivo treatment with N-acetylcysteine as a potential therapeutic intervention in mild..." Proteomics 11, 21 (2011): 4243-56. Details. Full text
  • Perluigi, M.;Butterfield, DA "The identification of protein biomarkers for oxidative stress in Down syndrome." Expert review of proteomics 8, 4 (2011): 427-9. Details.
  • Butterfield, DA ;Owen, JB "Lectin-affinity chromatography brain glycoproteomics and Alzheimer disease: insights into protein alterations consistent with the pathology and progression of this dementing disorder." Proteomics. Clinical applications 5, 1-2 (2011): 50-6. Details. Full text
  • Barone, E.;Di Domenico, F.;Cenini, G.;Sultana, R.;Cini, C.;Preziosi, P.;Perluigi, M.;Mancuso, C.;Butterfield, DA "Biliverdin reductase--a protein levels and activity in the brains of subjects with Alzheimer disease and mild cognitive impairment." Biochimica et biophysica acta 1812, 4 (2011): 480-7. Details. Full text
  • Martin, SB ;Cenini, G.;Barone, E.;Dowling, AL ;Mancuso, C.;Butterfield, DA ;Murphy, MP ;Head, E. "Coenzyme Q10 and cognition in atorvastatin treated dogs." Neuroscience letters 501, 2 (2011): 92-5. Details. Full text
  • Robinson, RA ;Lange, MB ;Sultana, R.;Galvan, V.;Fombonne, J.;Gorostiza, O.;Zhang, J.;Warrier, G.;Cai, J.;Pierce, WM ;Bredesen, DE ;Butterfield, DA "Differential expression and redox proteomics analyses of an Alzheimer disease transgenic mouse model: effects of the amyloid-β peptide of amyloid precursor protein." Neuroscience 177, (2011): 207-22. Details. Full text
  • Butterfield, DA "Preface for the special issue of neuromolecular medicine in memory of the life and legacy of William R. Markesbery, M.D." Neuromolecular medicine 13, 1 (2011): 1-2. Details. Full text
  • Sultana, R.;Robinson, RA ;Di Domenico, F.;Abdul, HM ;St Clair, DK ;Markesbery, WR ;Cai, J.;Pierce, WM ;Butterfield, DA "Proteomic identification of specifically carbonylated brain proteins in APP(NLh)/APP(NLh) × PS-1(P264L)/PS-1(P264L) human double mutant knock-in mice model of Alzheimer disease as a function of age." Journal of proteomics 74, 11 (2011): 2430-40. Details. Full text
  • Barone, E.;Cenini, G.;Di Domenico, F.;Martin, S.;Sultana, R.;Mancuso, C.;Murphy, MP ;Head, E.;Butterfield, DA "Long-term high-dose atorvastatin decreases brain oxidative and nitrosative stress in a preclinical model of Alzheimer disease: a novel mechanism of action." Pharmacological research 63, 3 (2011): 172-80. Details. Full text
  • Butterfield, DA "Oxidative stress in Alzheimer disease: synergy between the Butterfield and Markesbery laboratories." Neuromolecular medicine 13, 1 (2011): 19-22. Details. Full text
  • Pocernich, CB ;Lange, ML ;Sultana, R.;Butterfield, DA "Nutritional approaches to modulate oxidative stress in Alzheimer's disease." Current Alzheimer research 8, 5 (2011): 452-69. Details. Full text
  • Butterfield, DA "Atorvastatin and Aβ(1-40): not as simple as cholesterol reduction in brain and relevance to Alzheimer disease." Experimental neurology 228, 1 (2011): 15-8. Details. Full text
  • Butterfield, DA ;Barone, E.;Mancuso, C. "Cholesterol-independent neuroprotective and neurotoxic activities of statins: perspectives for statin use in Alzheimer disease and other age-related neurodegenerative disorders." Pharmacological research 64, 3 (2011): 180-6. Details. Full text
  • Sultana, R.;Butterfield, DA "Identification of the oxidative stress proteome in the brain." Free radical biology & medicine 50, 4 (2011): 487-94. Details. Full text
  • Wattamwar, PP ;Hardas, SS ;Butterfield, DA ;Anderson, KW ;Dziubla, TD "Tuning of the pro-oxidant and antioxidant activity of trolox through the controlled release from biodegradable poly(trolox ester) polymers." Journal of biomedical materials research. Part A 99, 2 (2011): 184-91. Details. Full text
  • Di Domenico, F.;Sultana, R.;Barone, E.;Perluigi, M.;Cini, C.;Mancuso, C.;Cai, J.;Pierce, WM ;Butterfield, DA "Quantitative proteomics analysis of phosphorylated proteins in the hippocampus of Alzheimer's disease subjects." Journal of proteomics 74, 7 (2011): 1091-103. Details. Full text
  • Butterfield, DA ;Reed, T ;Sultana, R. "Roles of 3-nitrotyrosine- and 4-hydroxynonenal-modified brain proteins in the progression and pathogenesis of Alzheimer's disease." Free radical research 45, 1 (2011): 59-72. Details. Full text
  • Aluise, CD ;Miriyala, S.;Noel, T.;Sultana, R.;Jungsuwadee, P.;Taylor, TJ ;Cai, J.;Pierce, WM ;Vore, M.;Moscow, JA ;St Clair, DK ;Butterfield, DA "2-Mercaptoethane sulfonate prevents doxorubicin-induced plasma protein oxidation and TNF-α release: implications for the reactive oxygen species-mediated mechanisms of chemobrain." Free radical biology & medicine 50, 11 (2011): 1630-8. Details. Full text
  • Reed, TT ;Sultana, R.;Butterfield, DA ;Alzate, O. "Redox Proteomics of Oxidatively Modified Brain Proteins in Mild Cognitive Impairment" (2011): Details.
  • Di Domenico, F.;Casalena, G ;Sultana, R.;Cai, J.;Pierce, WM ;Perluigi, M.;Cini, C.;Baracca, A ;Solaini, G ;Lenaz, G ;Jia, J.;Dziennis, S ;Murphy, SJ ;Alkayed, NJ ;Butterfield, DA "Involvement of Stat3 in mouse brain development and sexual dimorphism: a proteomics approach." Brain research 1362, (2010): 1-12. Details. Full text
  • Di Domenico, F.;Sultana, R.;Tiu, GF ;Scheff, NN ;Perluigi, M.;Cini, C.;Butterfield, DA "Protein levels of heat shock proteins 27, 32, 60, 70, 90 and thioredoxin-1 in amnestic mild cognitive impairment: an investigation on the role of cellular stress response in the progression of Alzheimer disease." Brain research 1333, (2010): 72-81. Details. Full text
  • Sultana, R.;Perluigi, M.;Newman, SF ;Pierce, WM ;Cini, C.;Coccia, R.;Butterfield, DA "Redox proteomic analysis of carbonylated brain proteins in mild cognitive impairment and early Alzheimer's disease." Antioxidants & redox signaling 12, 3 (2010): 327-36. Details. Full text
  • Owen, JB ;Sultana, R.;Aluise, CD ;Erickson, MA ;Price, TO ;Bu, G ;Banks, WA ;Butterfield, DA "Oxidative modification to LDL receptor-related protein 1 in hippocampus from subjects with Alzheimer disease: implications for Aβ accumulation in AD brain." Free radical biology & medicine 49, 11 (2010): 1798-803. Details. Full text
  • Perluigi, M.;Di Domenico, F.;Blarzino, C ;Foppoli, C.;Cini, C.;Giorgi, A.;Grillo, C ;De Marco, F ;Butterfield, DA ;Schininà, ME ;Coccia, R. "Effects of UVB-induced oxidative stress on protein expression and specific protein oxidation in normal human epithelial keratinocytes: a proteomic approach." Proteome science 8, (2010): 13. Details. Full text
  • Butterfield, DA ;Bader Lange, ML ;Sultana, R. "Involvements of the lipid peroxidation product, HNE, in the pathogenesis and progression of Alzheimer's disease." Biochimica et biophysica acta 1801, 8 (2010): 924-9. Details. Full text
  • Huang, Q.;Aluise, CD ;Joshi, G.;Sultana, R.;St Clair, DK ;Markesbery, WR ;Butterfield, DA "Potential in vivo amelioration by N-acetyl-L-cysteine of oxidative stress in brain in human double mutant APP/PS-1 knock-in mice: toward therapeutic modulation of mild cognitive impairment." Journal of neuroscience research 88, 12 (2010): 2618-29. Details. Full text
  • Joshi, G.;Aluise, CD ;Cole, MP ;Sultana, R.;Pierce, WM ;Vore, M.;St Clair, DK ;Butterfield, DA "Alterations in brain antioxidant enzymes and redox proteomic identification of oxidized brain proteins induced by the anti-cancer drug adriamycin: implications for oxidative stress-mediated chemobrain." Neuroscience 166, 3 (2010): 796-807. Details. Full text
  • Bader Lange, ML ;St Clair, D.;Markesbery, WR ;Studzinski, CM ;Murphy, MP ;Butterfield, DA "Age-related loss of phospholipid asymmetry in APP(NLh)/APP(NLh) x PS-1(P264L)/PS-1(P264L) human double mutant knock-in mice: relevance to Alzheimer disease." Neurobiology of disease 38, 1 (2010): 104-15. Details. Full text
  • Butterfield, DA ;Galvan, V.;Lange, MB ;Tang, H ;Sowell, RA ;Spilman, P ;Fombonne, J.;Gorostiza, O.;Zhang, J.;Sultana, R.;Bredesen, DE "In vivo oxidative stress in brain of Alzheimer disease transgenic mice: Requirement for methionine 35 in amyloid beta-peptide of APP." Free radical biology & medicine 48, 1 (2010): 136-44. Details. Full text
  • Di Domenico, F.;Perluigi, M.;Butterfield, DA ;Cornelius, C.;Calabrese, V. "Oxidative damage in rat brain during aging: interplay between energy and metabolic key target proteins." Neurochemical research 35, 12 (2010): 2184-92. Details. Full text
  • Hardas, SS ;Butterfield, DA ;Sultana, R.;Tseng, MT ;Dan, M ;Florence, RL ;Unrine, JM ;Graham, UM ;Wu, P ;Grulke, EA ;Yokel, RA "Brain distribution and toxicological evaluation of a systemically delivered engineered nanoscale ceria." Toxicological sciences : an official journal of the Society of Toxicology 116, 2 (2010): 562-76. Details. Full text
  • Sultana, R.;Di Domenico, F.;Tseng, M.;Cai, J.;Noel, T.;Chelvarajan, RL ;Pierce, WD ;Cini, C.;Bondada, S.;St Clair, DK ;Butterfield, DA "Doxorubicin-induced thymus senescence." Journal of proteome research 9, 12 (2010): 6232-41. Details. Full text
  • Aluise, CD ;Robinson, RA ;Beckett, TL ;Murphy, MP ;Cai, J.;Pierce, WM ;Markesbery, WR ;Butterfield, DA "Preclinical Alzheimer disease: brain oxidative stress, Abeta peptide and proteomics." Neurobiology of disease 39, 2 (2010): 221-8. Details. Full text
  • Sultana, R.;Banks, WA ;Butterfield, DA "Decreased levels of PSD95 and two associated proteins and increased levels of BCl2 and caspase 3 in hippocampus from subjects with amnestic mild cognitive impairment: Insights into their potential roles for loss of synapses and memory, accumulation of..." Journal of neuroscience research 88, 3 (2010): 469-77. Details. Full text
  • Reed, TT ;Owen, J ;Pierce, WM ;Sebastian, A ;Sullivan, PG ;Butterfield, DA "Proteomic identification of nitrated brain proteins in traumatic brain-injured rats treated postinjury with gamma-glutamylcysteine ethyl ester: insights into the role of elevation of glutathione as a potential therapeutic strategy for traumatic brain..." Journal of neuroscience research 87, 2 (2009): 408-17. Details. Full text
  • Reed, TT ;Pierce, WM ;Markesbery, WR ;Butterfield, DA "Proteomic identification of HNE-bound proteins in early Alzheimer disease: Insights into the role of lipid peroxidation in the progression of AD." Brain research 1274, (2009): 66-76. Details. Full text
  • Aluise, CD ;St Clair, D.;Vore, M.;Butterfield, DA "In vivo amelioration of adriamycin induced oxidative stress in plasma by gamma-glutamylcysteine ethyl ester (GCEE)." Cancer letters 282, 1 (2009): 25-9. Details. Full text
  • Sultana, R.;Perluigi, M.;Butterfield, DA "Oxidatively modified proteins in Alzheimer's disease (AD), mild cognitive impairment and animal models of AD: role of Abeta in pathogenesis." Acta neuropathologica 118, 1 (2009): 131-50. Details. Full text
  • Reed, TT ;WM, Pierce ;Turner, DM ;Markesbery, WR ;Butterfield, DA "Proteomic identification of nitrated brain proteins in early Alzheimer's disease inferior parietal lobule." Journal of cellular and molecular medicine 13, 8B (2009): 2019-29. Details. Full text
  • Jungsuwadee, P.;Nithipongvanitch, R ;Chen, Y.;Oberley, TD ;Butterfield, DA ;St Clair, DK ;Vore, M. "Mrp1 localization and function in cardiac mitochondria after doxorubicin." Molecular pharmacology 75, 5 (2009): 1117-26. Details. Full text
  • Sowell, RA ;Owen, JB ;Butterfield, DA "Proteomics in animal models of Alzheimer's and Parkinson's diseases." Ageing research reviews 8, 1 (2009): 1-17. Details. Full text
  • Di Domenico, F.;Cenini, G.;Sultana, R.;Perluigi, M.;Uberti, D ;Memo, M ;Butterfield, DA "Glutathionylation of the pro-apoptotic protein p53 in Alzheimer's disease brain: implications for AD pathogenesis." Neurochemical research 34, 4 (2009): 727-33. Details. Full text
  • Ansari, MA ;Abdul, HM ;Joshi, G.;Opii, WO ;Butterfield, DA "Protective effect of quercetin in primary neurons against Abeta(1-42): relevance to Alzheimer's disease." The Journal of nutritional biochemistry 20, 4 (2009): 269-75. Details. Full text
  • Butterfield, DA ;Lange, ML "Multifunctional roles of enolase in Alzheimer's disease brain: beyond altered glucose metabolism." Journal of neurochemistry 111, 4 (2009): 915-33. Details. Full text
  • Sultana, R.;Butterfield, DA "Oxidatively modified, mitochondria-relevant brain proteins in subjects with Alzheimer disease and mild cognitive impairment." Journal of bioenergetics and biomembranes 41, 5 (2009): 441-6. Details. Full text
  • Owen, JB ;Di Domenico, F.;Sultana, R.;Perluigi, M.;Cini, C.;Pierce, WM ;Butterfield, DA "Proteomics-determined differences in the concanavalin-A-fractionated proteome of hippocampus and inferior parietal lobule in subjects with Alzheimer's disease and mild cognitive impairment: implications for progression of AD." Journal of proteome research 8, 2 (2009): 471-82. Details. Full text
  • Owen, JB ;Opii, WO ;Ramassamy, C ;Pierce, WM ;Butterfield, DA "Proteomic analysis of brain protein expression levels in NF-kappabeta p50 -/- homozygous knockout mice." Brain research 1240, (2008): 22-30. Details. Full text
  • Sultana, R.;Butterfield, DA "Redox proteomics studies of in vivo amyloid beta-peptide animal models of Alzheimer's disease: Insight into the role of oxidative stress." Proteomics. Clinical applications 2, 5 (2008): 685-96. Details. Full text
  • Cenini, G.;Sultana, R.;Memo, M ;Butterfield, DA "Effects of oxidative and nitrosative stress in brain on p53 proapoptotic protein in amnestic mild cognitive impairment and Alzheimer disease." Free radical biology & medicine 45, 1 (2008): 81-5. Details. Full text
  • Abdul, HM ;Sultana, R.;St Clair, DK ;Markesbery, WR ;Butterfield, DA "Oxidative damage in brain from human mutant APP/PS-1 double knock-in mice as a function of age." Free radical biology & medicine 45, 10 (2008): 1420-5. Details. Full text
  • Aluise, CD ;Sowell, RA ;Butterfield, DA "Peptides and proteins in plasma and cerebrospinal fluid as biomarkers for the prediction, diagnosis, and monitoring of therapeutic efficacy of Alzheimer's disease." Biochimica et biophysica acta 1782, 10 (2008): 549-58. Details. Full text
  • Sompol, P ;Ittarat, W ;Tangpong, J ;Chen, Y.;Doubinskaia, I ;Batinic-Haberle, I ;Abdul, HM ;Butterfield, DA ;St Clair, DK "A neuronal model of Alzheimer's disease: an insight into the mechanisms of oxidative stress-mediated mitochondrial injury." Neuroscience 153, 1 (2008): 120-30. Details. Full text
  • Reed, T ;Perluigi, M.;Sultana, R.;Pierce, WM ;Klein, JB ;Turner, DM ;Coccia, R.;Markesbery, WR ;Butterfield, DA "Redox proteomic identification of 4-hydroxy-2-nonenal-modified brain proteins in amnestic mild cognitive impairment: insight into the role of lipid peroxidation in the progression and pathogenesis of Alzheimer's disease." Neurobiology of disease 30, 1 (2008): 107-20. Details. Full text
  • Sultana, R.;Piroddi, M ;Galli, F ;Butterfield, DA "Protein levels and activity of some antioxidant enzymes in hippocampus of subjects with amnestic mild cognitive impairment." Neurochemical research 33, 12 (2008): 2540-6. Details. Full text
  • Bader Lange, ML ;Cenini, G.;Piroddi, M ;Abdul, HM ;Sultana, R.;Galli, F ;Memo, M ;Butterfield, DA "Loss of phospholipid asymmetry and elevated brain apoptotic protein levels in subjects with amnestic mild cognitive impairment and Alzheimer disease." Neurobiology of disease 29, 3 (2008): 456-64. Details. Full text
  • Opii, WO ;Joshi, G.;Head, E.;Milgram, NW ;Muggenburg, BA ;Klein, JB ;Pierce, WM ;Cotman, CW ;Butterfield, DA "Proteomic identification of brain proteins in the canine model of human aging following a long-term treatment with antioxidants and a program of behavioral enrichment: relevance to Alzheimer's disease." Neurobiology of aging 29, 1 (2008): 51-70. Details. Full text
  • Sultana, R.;Butterfield, DA "Alterations of some membrane transport proteins in Alzheimer's disease: role of amyloid beta-peptide." Molecular bioSystems 4, 1 (2008): 36-41. Details. Full text
  • Cenini, G.;Sultana, R.;Memo, M ;Butterfield, DA "Elevated levels of pro-apoptotic p53 and its oxidative modification by the lipid peroxidation product, HNE, in brain from subjects with amnestic mild cognitive impairment and Alzheimer's disease." Journal of cellular and molecular medicine 12, 3 (2008): 987-94. Details. Full text
  • Oesterling, E ;Chopra, N ;Gavalas, V ;Arzuaga, X ;Lim, EJ ;Sultana, R.;Butterfield, DA ;Bachas, L ;Hennig, B "Alumina nanoparticles induce expression of endothelial cell adhesion molecules." Toxicology letters 178, 3 (2008): 160-6. Details. Full text
  • Joshi, G.;Hardas, S ;Sultana, R.;St Clair, DK ;Vore, M.;Butterfield, DA "Glutathione elevation by gamma-glutamyl cysteine ethyl ester as a potential therapeutic strategy for preventing oxidative stress in brain mediated by in vivo administration of adriamycin: Implication for chemobrain." Journal of neuroscience research 85, 3 (2007): 497-503. Details. Full text
  • Butterfield, DA ;Reed, T ;Newman, SF ;Sultana, R. "Roles of amyloid beta-peptide-associated oxidative stress and brain protein modifications in the pathogenesis of Alzheimer's disease and mild cognitive impairment." Free radical biology & medicine 43, 5 (2007): 658-77. Details. Full text
  • Chen, Y.;Jungsuwadee, P.;Vore, M.;Butterfield, DA ;St Clair, DK "Collateral damage in cancer chemotherapy: oxidative stress in nontargeted tissues." Molecular interventions 7, 3 (2007): 147-56. Details.
  • Mello, CF ;Sultana, R.;Piroddi, M ;Cai, J.;Pierce, WM ;Klein, JB ;Butterfield, DA "Acrolein induces selective protein carbonylation in synaptosomes." Neuroscience 147, 3 (2007): 674-9. Details. Full text
  • Sultana, R.;Boyd-Kimball, D ;Cai, J.;Pierce, WM ;Klein, JB ;Merchant, M ;Butterfield, DA "Proteomics analysis of the Alzheimer's disease hippocampal proteome." Journal of Alzheimer's disease : JAD 11, 2 (2007): 153-64. Details. Full text
  • Vaishnav, RA ;Getchell, ML ;Poon, HF ;Barnett, KR ;Hunter, SA ;Pierce, WM ;Klein, JB ;Butterfield, DA ;Getchell, TV "Oxidative stress in the aging murine olfactory bulb: redox proteomics and cellular localization." Journal of neuroscience research 85, 2 (2007): 373-85. Details. Full text
  • Opii, WO ;Nukala, VN ;Sultana, R.;Pandya, JD ;Day, KM ;Merchant, ML ;Klein, JB ;Sullivan, PG ;Butterfield, DA "Proteomic identification of oxidized mitochondrial proteins following experimental traumatic brain injury." Journal of neurotrauma 24, 5 (2007): 772-89. Details. Full text
  • Butterfield, DA ;Reed, TT ;Perluigi, M.;De Marco, C ;Coccia, R.;Keller, JN ;Markesbery, WR ;Sultana, R. "Elevated levels of 3-nitrotyrosine in brain from subjects with amnestic mild cognitive impairment: implications for the role of nitration in the progression of Alzheimer's disease." Brain research 1148, (2007): 243-8. Details. Full text
  • Newman, SF ;Sultana, R.;Perluigi, M.;Coccia, R.;Cai, J.;Pierce, WM ;Klein, JB ;Turner, DM ;Butterfield, DA "An increase in S-glutathionylated proteins in the Alzheimer's disease inferior parietal lobule, a proteomics approach." Journal of neuroscience research 85, 7 (2007): 1506-14. Details. Full text
  • Opii, WO ;Sultana, R.;Abdul, HM ;Ansari, MA ;Nath, A.;Butterfield, DA "Oxidative stress and toxicity induced by the nucleoside reverse transcriptase inhibitor (NRTI)--2',3'-dideoxycytidine (ddC): relevance to HIV-dementia." Experimental neurology 204, 1 (2007): 29-38. Details. Full text
  • Tangpong, J ;Cole, MP ;Sultana, R.;Estus, S ;Vore, M.;St Clair, W ;Ratanachaiyavong, S ;St Clair, DK ;Butterfield, DA "Adriamycin-mediated nitration of manganese superoxide dismutase in the central nervous system: insight into the mechanism of chemobrain." Journal of neurochemistry 100, 1 (2007): 191-201. Details. Full text
  • Abdul, HM ;Butterfield, DA "Involvement of PI3K/PKG/ERK1/2 signaling pathways in cortical neurons to trigger protection by cotreatment of acetyl-L-carnitine and alpha-lipoic acid against HNE-mediated oxidative stress and neurotoxicity: implications for Alzheimer's disease." Free radical biology & medicine 42, 3 (2007): 371-84. Details. Full text
  • Butterfield, DA ;Sultana, R. "Redox proteomics identification of oxidatively modified brain proteins in Alzheimer's disease and mild cognitive impairment: insights into the progression of this dementing disorder." Journal of Alzheimer's disease : JAD 12, 1 (2007): 61-72. Details. Full text
  • Butterfield, DA ;Reed, T ;Perluigi, M.;De Marco, C ;Coccia, R.;Cini, C.;Sultana, R. "Elevated protein-bound levels of the lipid peroxidation product, 4-hydroxy-2-nonenal, in brain from persons with mild cognitive impairment." Neuroscience letters 397, 3 (2006): 170-3. Details. Full text
  • Ansari, MA ;Joshi, G.;Huang, Q.;Opii, WO ;Abdul, HM ;Sultana, R.;Butterfield, DA "In vivo administration of D609 leads to protection of subsequently isolated gerbil brain mitochondria subjected to in vitro oxidative stress induced by amyloid beta-peptide and other oxidative stressors: relevance to Alzheimer's disease and other..." Free radical biology & medicine 41, 11 (2006): 1694-703. Details. Full text
  • Butterfield, DA ;Abdul, HM ;Opii, W ;Newman, SF ;Joshi, G.;Ansari, MA ;Sultana, R. "Pin1 in Alzheimer's disease." Journal of neurochemistry 98, 6 (2006): 1697-706. Details. Full text
  • Joshi, G.;Perluigi, M.;Sultana, R.;Agrippino, R ;Calabrese, V.;Butterfield, DA "In vivo protection of synaptosomes by ferulic acid ethyl ester (FAEE) from oxidative stress mediated by 2,2-azobis(2-amidino-propane)dihydrochloride (AAPH) or Fe(2+)/H(2)O(2): insight into mechanisms of neuroprotection and relevance to oxidative..." Neurochemistry international 48, 4 (2006): 318-27. Details. Full text
  • Poon, HF ;Shepherd, HM ;Reed, TT ;Calabrese, V.;Stella, AM ;Pennisi, G ;Cai, J.;Pierce, WM ;Klein, JB ;Butterfield, DA "Proteomics analysis provides insight into caloric restriction mediated oxidation and expression of brain proteins associated with age-related impaired cellular processes: Mitochondrial dysfunction, glutamate dysregulation and impaired protein synthesis." Neurobiology of aging 27, 7 (2006): 1020-34. Details. Full text
  • Butterfield, DA ;Perluigi, M.;Sultana, R. "Oxidative stress in Alzheimer's disease brain: new insights from redox proteomics." European journal of pharmacology 545, 1 (2006): 39-50. Details. Full text
  • Sultana, R.;Poon, HF ;Cai, J.;Pierce, WM ;Merchant, M ;Klein, JB ;Markesbery, WR ;Butterfield, DA "Identification of nitrated proteins in Alzheimer's disease brain using a redox proteomics approach." Neurobiology of disease 22, 1 (2006): 76-87. Details. Full text
  • Poon, HF ;Vaishnav, RA ;Getchell, TV ;Getchell, ML ;Butterfield, DA "Quantitative proteomics analysis of differential protein expression and oxidative modification of specific proteins in the brains of old mice." Neurobiology of aging 27, 7 (2006): 1010-9. Details. Full text
  • Butterfield, DA ;Abdul, HM ;Newman, S ;Reed, T "Redox proteomics in some age-related neurodegenerative disorders or models thereof." NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics 3, 3 (2006): 344-57. Details. Full text
  • Crooks, PA ;Kottayil, SG ;Al-Ghananeem, AM ;Butterfield, DA "Opiate receptor binding properties of morphine-, dihydromorphine-, and codeine 6-O-sulfate ester congeners." Bioorganic & medicinal chemistry letters 16, 16 (2006): 4291-5. Details. Full text
  • Sultana, R.;Boyd-Kimball, D ;Poon, HF ;Cai, J.;Pierce, WM ;Klein, JB ;Merchant, M ;Markesbery, WR ;Butterfield, DA "Redox proteomics identification of oxidized proteins in Alzheimer's disease hippocampus and cerebellum: an approach to understand pathological and biochemical alterations in AD." Neurobiology of aging 27, 11 (2006): 1564-76. Details. Full text
  • Jungsuwadee, P.;Cole, MP ;Sultana, R.;Joshi, G.;Tangpong, J ;Butterfield, DA ;St Clair, DK ;Vore, M. "Increase in Mrp1 expression and 4-hydroxy-2-nonenal adduction in heart tissue of Adriamycin-treated C57BL/6 mice." Molecular cancer therapeutics 5, 11 (2006): 2851-60. Details. Full text
  • Sultana, R.;Boyd-Kimball, D ;Poon, HF ;Cai, J.;Pierce, WM ;Klein, JB ;Markesbery, WR ;Zhou, XZ ;Lu, KP ;Butterfield, DA "Oxidative modification and down-regulation of Pin1 in Alzheimer's disease hippocampus: A redox proteomics analysis." Neurobiology of aging 27, 7 (2006): 918-25. Details. Full text
  • Tangpong, J ;Cole, MP ;Sultana, R.;Joshi, G.;Estus, S ;Vore, M.;St Clair, W ;Ratanachaiyavong, S ;St Clair, DK ;Butterfield, DA "Adriamycin-induced, TNF-alpha-mediated central nervous system toxicity." Neurobiology of disease 23, 1 (2006): 127-39. Details. Full text
  • Sultana, R.;Perluigi, M.;Butterfield, DA "Redox proteomics identification of oxidatively modified proteins in Alzheimer's disease brain and in vivo and in vitro models of AD centered around Abeta(1-42)." Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 833, 1 (2006): 3-11. Details. Full text
  • Smuleac, V ;Butterfield, DA ;Bhattacharyya, D "Layer-by-layer-assembled microfiltration membranes for biomolecule immobilization and enzymatic catalysis." Langmuir : the ACS journal of surfaces and colloids 22, 24 (2006): 10118-24. Details. Full text
  • Boyd-Kimball, D ;Poon, HF ;Lynn, BC ;Cai, J.;WM, Pierce ;Klein, JB ;Ferguson, J ;Link, CD ;Butterfield, DA "Proteomic identification of proteins specifically oxidized in Caenorhabditis elegans expressing human Abeta(1-42): implications for Alzheimer's disease." Neurobiology of aging 27, 9 (2006): 1239-49. Details. Full text
  • Abdul, HM ;Calabrese, V.;Calvani, M ;Butterfield, DA "Acetyl-L-carnitine-induced up-regulation of heat shock proteins protects cortical neurons against amyloid-beta peptide 1-42-mediated oxidative stress and neurotoxicity: implications for Alzheimer's disease." Journal of neuroscience research 84, 2 (2006): 398-408. Details. Full text
  • Sultana, R.;Newman, SF ;Abdul, HM ;Cai, J.;Pierce, WM ;Klein, JB ;Merchant, M ;Butterfield, DA "Protective effect of D609 against amyloid-beta1-42-induced oxidative modification of neuronal proteins: redox proteomics study." Journal of neuroscience research 84, 2 (2006): 409-17. Details. Full text
  • Abdul, Mohmmad ;Sultana, R.;Keller, JN ;St Clair, DK ;Markesbery, WR ;Butterfield, DA "Mutations in amyloid precursor protein and presenilin-1 genes increase the basal oxidative stress in murine neuronal cells and lead to increased sensitivity to oxidative stress mediated by amyloid beta-peptide (1-42), HO and kainic acid: implications..." Journal of neurochemistry 96, 5 (2006): 1322-35. Details. Full text
  • Butterfield, DA ;Gnjec, A ;Poon, HF ;Castegna, A ;Pierce, WM ;Klein, JB ;Martins, RN "Redox proteomics identification of oxidatively modified brain proteins in inherited Alzheimer's disease: an initial assessment." Journal of Alzheimer's disease : JAD 10, 4 (2006): 391-7. Details. Full text
  • Chen, Y.;Daosukho, C ;Opii, WO ;Turner, DM ;Pierce, WM ;Klein, JB ;Vore, M.;Butterfield, DA ;St Clair, DK "Redox proteomic identification of oxidized cardiac proteins in adriamycin-treated mice." Free radical biology & medicine 41, 9 (2006): 1470-7. Details. Full text
  • Butterfield, DA ;Poon, HF ;St Clair, D.;Keller, JN ;Pierce, WM ;Klein, JB ;Markesbery, WR "Redox proteomics identification of oxidatively modified hippocampal proteins in mild cognitive impairment: insights into the development of Alzheimer's disease." Neurobiology of disease 22, 2 (2006): 223-32. Details. Full text
  • Joshi, G.;Sultana, R.;Perluigi, M.;Butterfield, DA "In vivo protection of synaptosomes from oxidative stress mediated by Fe2+/H2O2 or 2,2-azobis-(2-amidinopropane) dihydrochloride by the glutathione mimetic tricyclodecan-9-yl-xanthogenate." Free radical biology & medicine 38, 8 (2005): 1023-31. Details. Full text
  • Poon, HF ;Farr, SA ;Thongboonkerd, V ;Lynn, BC ;Banks, WA ;Morley, JE ;Klein, JB ;Butterfield, DA "Proteomic analysis of specific brain proteins in aged SAMP8 mice treated with alpha-lipoic acid: implications for aging and age-related neurodegenerative disorders." Neurochemistry international 46, 2 (2005): 159-68. Details. Full text
  • Poon, HF ;Frasier, M ;Shreve, N ;Calabrese, V.;Wolozin, B ;Butterfield, DA "Mitochondrial associated metabolic proteins are selectively oxidized in A30P alpha-synuclein transgenic mice--a model of familial Parkinson's disease." Neurobiology of disease 18, 3 (2005): 492-8. Details. Full text
  • Boyd-Kimball, D ;Sultana, R.;Mohmmad-Abdul, H ;Butterfield, DA "Neurotoxicity and oxidative stress in D1M-substituted Alzheimer's A beta(1-42): relevance to N-terminal methionine chemistry in small model peptides." Peptides 26, 4 (2005): 665-73. Details. Full text
  • Pocernich, CB ;Boyd-Kimball, D ;Poon, HF ;Thongboonkerd, V ;Lynn, BC ;Klein, JB ;Calebrese, V ;Nath, A.;Butterfield, DA "Proteomics analysis of human astrocytes expressing the HIV protein Tat." Brain research. Molecular brain research 133, 2 (2005): 307-16. Details. Full text
  • Joshi, G.;Sultana, R.;Tangpong, J ;Cole, MP ;St Clair, DK ;Vore, M.;Estus, S ;Butterfield, DA "Free radical mediated oxidative stress and toxic side effects in brain induced by the anti cancer drug adriamycin: insight into chemobrain." Free radical research 39, 11 (2005): 1147-54. Details. Full text
  • Abdul, Mohmmad ;Butterfield, DA "Protection against amyloid beta-peptide (1-42)-induced loss of phospholipid asymmetry in synaptosomal membranes by tricyclodecan-9-xanthogenate (D609) and ferulic acid ethyl ester: implications for Alzheimer's disease." Biochimica et biophysica acta 1741, 1-2 (2005): 140-8. Details. Full text
  • Pocernich, CB ;Poon, HF ;Boyd-Kimball, D ;Lynn, BC ;Nath, A.;Klein, JB ;Butterfield, DA "Proteomic analysis of oxidatively modified proteins induced by the mitochondrial toxin 3-nitropropionic acid in human astrocytes expressing the HIV protein tat." Brain research. Molecular brain research 133, 2 (2005): 299-306. Details. Full text
  • Sultana, R.;Ravagna, A ;Mohmmad-Abdul, H ;Calabrese, V.;Butterfield, DA "Ferulic acid ethyl ester protects neurons against amyloid beta- peptide(1-42)-induced oxidative stress and neurotoxicity: relationship to antioxidant activity." Journal of neurochemistry 92, 4 (2005): 749-58. Details. Full text
  • Poon, HF ;Farr, SA ;Banks, WA ;Pierce, WM ;Klein, JB ;Morley, JE ;Butterfield, DA "Proteomic identification of less oxidized brain proteins in aged senescence-accelerated mice following administration of antisense oligonucleotide directed at the Abeta region of amyloid precursor protein." Brain research. Molecular brain research 138, 1 (2005): 8-16. Details. Full text
  • Butterfield, DA ;Boyd-Kimball, D "The critical role of methionine 35 in Alzheimer's amyloid beta-peptide (1-42)-induced oxidative stress and neurotoxicity." Biochimica et biophysica acta 1703, 2 (2005): 149-56. Details. Full text
  • Pocernich, CB ;Sultana, R.;Mohmmad-Abdul, H ;Nath, A.;Butterfield, DA "HIV-dementia, Tat-induced oxidative stress, and antioxidant therapeutic considerations." Brain research. Brain research reviews 50, 1 (2005): 14-26. Details. Full text
  • Boyd-Kimball, D ;Sultana, R.;Abdul, HM ;Butterfield, DA "Gamma-glutamylcysteine ethyl ester-induced up-regulation of glutathione protects neurons against Abeta(1-42)-mediated oxidative stress and neurotoxicity: implications for Alzheimer's disease." Journal of neuroscience research 79, 5 (2005): 700-6. Details. Full text
  • Poon, HF ;Hensley, K ;Thongboonkerd, V ;Merchant, ML ;Lynn, BC ;Pierce, WM ;Klein, JB ;Calabrese, V.;Butterfield, DA "Redox proteomics analysis of oxidatively modified proteins in G93A-SOD1 transgenic mice--a model of familial amyotrophic lateral sclerosis." Free radical biology & medicine 39, 4 (2005): 453-62. Details. Full text
  • Boyd-Kimball, D ;Castegna, A ;Sultana, R.;Poon, HF ;Petroze, R ;Lynn, BC ;Klein, JB ;Butterfield, DA "Proteomic identification of proteins oxidized by Abeta(1-42) in synaptosomes: implications for Alzheimer's disease." Brain research 1044, 2 (2005): 206-15. Details. Full text
  • Butterfield, DA ;Poon, HF "The senescence-accelerated prone mouse (SAMP8): a model of age-related cognitive decline with relevance to alterations of the gene expression and protein abnormalities in Alzheimer's disease." Experimental gerontology 40, 10 (2005): 774-83. Details. Full text
  • Keller, JN ;Schmitt, FA ;Scheff, SW ;Ding, Q.;Chen, Q.;Butterfield, DA ;Markesbery, WR "Evidence of increased oxidative damage in subjects with mild cognitive impairment." Neurology 64, 7 (2005): 1152-6. Details. Full text
  • Boyd-Kimball, D ;Sultana, R.;Poon, HF ;Mohmmad-Abdul, H ;Lynn, BC ;Klein, JB ;Butterfield, DA "Gamma-glutamylcysteine ethyl ester protection of proteins from Abeta(1-42)-mediated oxidative stress in neuronal cell culture: a proteomics approach." Journal of neuroscience research 79, 5 (2005): 707-13. Details. Full text
  • Poon, HF ;Vaishnav, RA ;Butterfield, DA ;Getchell, ML ;Getchell, TV "Proteomic identification of differentially expressed proteins in the aging murine olfactory system and transcriptional analysis of the associated genes." Journal of neurochemistry 94, 2 (2005): 380-92. Details. Full text
  • Poon, HF ;Joshi, G.;Sultana, R.;Farr, SA ;Banks, WA ;Morley, JE ;Calabrese, V.;Butterfield, DA "Antisense directed at the Abeta region of APP decreases brain oxidative markers in aged senescence accelerated mice." Brain research 1018, 1 (2004): 86-96. Details. Full text
  • Boyd-Kimball, D ;Abdul, Mohmmad ;Reed, T ;Sultana, R.;Butterfield, DA "Role of phenylalanine 20 in Alzheimer's amyloid beta-peptide (1-42)-induced oxidative stress and neurotoxicity." Chemical research in toxicology 17, 12 (2004): 1743-9. Details. Full text
  • Poon, HF ;Calabrese, V.;Scapagnini, G ;Butterfield, DA "Free radicals and brain aging." Clinics in geriatric medicine 20, 2 (2004): 329-59. Details. Full text
  • Butterfield, DA ;Boyd-Kimball, D "Amyloid beta-peptide(1-42) contributes to the oxidative stress and neurodegeneration found in Alzheimer disease brain." Brain pathology (Zurich, Switzerland) 14, 4 (2004): 426-32. Details. Full text
  • Boyd-Kimball, D ;Sultana, R.;Mohmmad-Abdul, H ;Butterfield, DA "Rodent Abeta(1-42) exhibits oxidative stress properties similar to those of human Abeta(1-42): Implications for proposed mechanisms of toxicity." Journal of Alzheimer's disease : JAD 6, 5 (2004): 515-25. Details. Full text
  • Poon, HF ;Calabrese, V.;Scapagnini, G ;Butterfield, DA "Free radicals: key to brain aging and heme oxygenase as a cellular response to oxidative stress." The journals of gerontology. Series A, Biological sciences and medical sciences 59, 5 (2004): 478-93. Details. Full text
  • Maragos, WF ;Young, KL ;Altman, CS ;Pocernich, CB ;Drake, J ;Butterfield, DA ;Seif, I ;Holschneider, DP ;Chen, K ;Shih, JC "Striatal damage and oxidative stress induced by the mitochondrial toxin malonate are reduced in clorgyline-treated rats and MAO-A deficient mice." Neurochemical research 29, 4 (2004): 741-6. Details.
  • Abdul, Mohmmad ;Wenk, GL ;Gramling, M ;Hauss-Wegrzyniak, B ;Butterfield, DA "APP and PS-1 mutations induce brain oxidative stress independent of dietary cholesterol: implications for Alzheimer's disease." Neuroscience letters 368, 2 (2004): 148-50. Details. Full text
  • Butterfield, DA "Proteomics: a new approach to investigate oxidative stress in Alzheimer's disease brain." Brain research 1000, 1-2 (2004): 1-7. Details. Full text
  • Sultana, R.;Newman, S ;Mohmmad-Abdul, H ;Keller, JN ;Butterfield, DA "Protective effect of the xanthate, D609, on Alzheimer's amyloid beta-peptide (1-42)-induced oxidative stress in primary neuronal cells." Free radical research 38, 5 (2004): 449-58. Details. Full text
  • Castegna, A ;Lauderback, CM ;Mohmmad-Abdul, H ;Butterfield, DA "Modulation of phospholipid asymmetry in synaptosomal membranes by the lipid peroxidation products, 4-hydroxynonenal and acrolein: implications for Alzheimer's disease." Brain research 1004, 1-2 (2004): 193-7. Details. Full text
  • Pocernich, CB ;Sultana, R.;Hone, E ;Turchan, J ;Martins, RN ;Calabrese, V.;Nath, A.;Butterfield, DA "Effects of apolipoprotein E on the human immunodeficiency virus protein Tat in neuronal cultures and synaptosomes." Journal of neuroscience research 77, 4 (2004): 532-9. Details. Full text
  • Castegna, A ;Thongboonkerd, V ;Klein, J.;Lynn, BC ;Wang, YL ;Osaka, H ;Wada, K.;Butterfield, DA "Proteomic analysis of brain proteins in the gracile axonal dystrophy (gad) mouse, a syndrome that emanates from dysfunctional ubiquitin carboxyl-terminal hydrolase L-1, reveals oxidation of key proteins." Journal of neurochemistry 88, 6 (2004): 1540-6. Details. Full text
  • Sultana, R.;Butterfield, DA "Oxidatively modified GST and MRP1 in Alzheimer's disease brain: implications for accumulation of reactive lipid peroxidation products." Neurochemical research 29, 12 (2004): 2215-20. Details.
  • Drake, J ;Sultana, R.;Aksenova, M ;Calabrese, V.;Butterfield, DA "Elevation of mitochondrial glutathione by gamma-glutamylcysteine ethyl ester protects mitochondria against peroxynitrite-induced oxidative stress." Journal of neuroscience research 74, 6 (2003): 917-27. Details. Full text
  • Butterfield, DA "Amyloid beta-peptide 1-42 -associated free radical-induced oxidative stress and neurodegeneration in Alzheimer's disease brain: mechanisms and consequences." Current medicinal chemistry 10, 24 (2003): 2651-9. Details. Full text
  • Butterfield, DA ;Castegna, A "Proteomic analysis of oxidatively modified proteins in Alzheimer's disease brain: insights into neurodegeneration." Cellular and molecular biology (Noisy-le-Grand, France) 49, 5 (2003): 747-51. Details.
  • Turchan, J ;Pocernich, CB ;Gairola, C ;Chauhan, A.;Schifitto, G ;Butterfield, DA ;Buch, S ;Narayan, O ;Sinai, A ;Geiger, J ;Elford, H ;Nath, A. "Oxidative stress in HIV demented patients and protection ex vivo with novel antioxidants." Neurology 60, 2 (2003): 307-14. Details. Full text
  • Kanski, J ;Sultana, R.;Klunk, W ;Butterfield, DA "Antioxidant activity of X-34 in synaptosomal and neuronal systems." Brain research 988, 1-2 (2003): 173-9. Details. Full text
  • Downie, AB ;Zhang, D.;Dirk, LM ;Thacker, RR ;Pfeiffer, JA ;Drake, JL ;Levy, AA ;Butterfield, DA ;Buxton, JW ;Snyder, JC "Communication between the maternal testa and the embryo and/or endosperm affect testa attributes in tomato." Plant physiology 133, 1 (2003): 145-60. Details. Full text
  • Butterfield, DA ;Boyd-Kimball, D ;Castegna, A "Proteomics in Alzheimer's disease: insights into potential mechanisms of neurodegeneration." Journal of neurochemistry 86, 6 (2003): 1313-27. Details. Full text
  • Ding, Q.;Reinacker, K ;Dimayuga, E ;Nukala, V ;Drake, J ;Butterfield, DA ;Dunn, JC ;Martin, S.;Bruce-Keller, AJ ;Keller, JN "Role of the proteasome in protein oxidation and neural viability following low-level oxidative stress." FEBS letters 546, 2-3 (2003): 228-32. Details. Full text
  • Castegna, A ;Thongboonkerd, V ;Klein, JB ;Lynn, B.;Markesbery, WR ;Butterfield, DA "Proteomic identification of nitrated proteins in Alzheimer's disease brain." Journal of neurochemistry 85, 6 (2003): 1394-401. Details. Full text
  • Butterfield, DA ;Castegna, A "Proteomics for the identification of specifically oxidized proteins in brain: technology and application to the study of neurodegenerative disorders." Amino acids 25, 3-4 (2003): 419-25. Details. Full text
  • Lauderback, CM ;Drake, J ;Zhou, D.;Hackett, JM ;Castegna, A ;Kanski, J ;Tsoras, M ;Varadarajan, S ;Butterfield, DA "Derivatives of xanthic acid are novel antioxidants: application to synaptosomes." Free radical research 37, 4 (2003): 355-65. Details. Full text
  • Castegna, A ;Aksenov, M ;Aksenova, M ;Thongboonkerd, V ;Klein, JB ;Pierce, WM ;Booze, R ;Markesbery, WR ;Butterfield, DA "Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part I: creatine kinase BB, glutamine synthase, and ubiquitin carboxy-terminal hydrolase L-1." Free radical biology & medicine 33, 4 (2002): 562-71. Details. Full text
  • Butterfield, DA "Amyloid beta-peptide (1-42)-induced oxidative stress and neurotoxicity: implications for neurodegeneration in Alzheimer's disease brain. A review." Free radical research 36, 12 (2002): 1307-13. Details. Full text
  • Butterfield, DA ;Kanski, J "Methionine residue 35 is critical for the oxidative stress and neurotoxic properties of Alzheimer's amyloid beta-peptide 1-42." Peptides 23, 7 (2002): 1299-309. Details. Full text
  • Drake, J ;Kanski, J ;Varadarajan, S ;Tsoras, M ;Butterfield, DA "Elevation of brain glutathione by gamma-glutamylcysteine ethyl ester protects against peroxynitrite-induced oxidative stress." Journal of neuroscience research 68, 6 (2002): 776-84. Details. Full text
  • Kanski, J ;Aksenova, M ;Schöneich, C ;Butterfield, DA "Substitution of isoleucine-31 by helical-breaking proline abolishes oxidative stress and neurotoxic properties of Alzheimer's amyloid beta-peptide." Free radical biology & medicine 32, 11 (2002): 1205-11. Details. Full text
  • Butterfield, DA ;Lauderback, CM "Lipid peroxidation and protein oxidation in Alzheimer's disease brain: potential causes and consequences involving amyloid beta-peptide-associated free radical oxidative stress." Free radical biology & medicine 32, 11 (2002): 1050-60. Details. Full text
  • Castegna, A ;Aksenov, M ;Thongboonkerd, V ;Klein, JB ;Pierce, WM ;Booze, R ;Markesbery, WR ;Butterfield, DA "Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part II: dihydropyrimidinase-related protein 2, alpha-enolase and heat shock cognate 71." Journal of neurochemistry 82, 6 (2002): 1524-32. Details. Full text
  • Kanski, J ;Aksenova, M ;Stoyanova, A ;Butterfield, DA "Ferulic acid antioxidant protection against hydroxyl and peroxyl radical oxidation in synaptosomal and neuronal cell culture systems in vitro: structure-activity studies." The Journal of nutritional biochemistry 13, 5 (2002): 273-281. Details. Full text
  • Butterfield, DA ;Griffin, S ;Munch, G ;Pasinetti, GM "Amyloid beta-peptide and amyloid pathology are central to the oxidative stress and inflammatory cascades under which Alzheimer's disease brain exists." Journal of Alzheimer's disease : JAD 4, 3 (2002): 193-201. Details. Full text
  • Kanski, J ;Varadarajan, S ;Aksenova, M ;Butterfield, DA "Role of glycine-33 and methionine-35 in Alzheimer's amyloid beta-peptide 1-42-associated oxidative stress and neurotoxicity." Biochimica et biophysica acta 1586, 2 (2002): 190-8. Details. Full text
  • Lauderback, CM ;Kanski, J ;Hackett, JM ;Maeda, N ;Kindy, MS ;Butterfield, DA "Apolipoprotein E modulates Alzheimer's Abeta(1-42)-induced oxidative damage to synaptosomes in an allele-specific manner." Brain research 924, 1 (2002): 90-7. Details. Full text
  • Kanski, J ;Aksenova, M ;Butterfield, DA "The hydrophobic environment of Met35 of Alzheimer's Abeta(1-42) is important for the neurotoxic and oxidative properties of the peptide." Neurotoxicity research 4, 3 (2002): 219-23. Details. Full text
  • Butterfield, DA ;Castegna, A ;Drake, J ;Scapagnini, G ;Calabrese, V. "Vitamin E and neurodegenerative disorders associated with oxidative stress." Nutritional neuroscience 5, 4 (2002): 229-39. Details. Full text
  • Zhou, D.;Lauderback, CM ;Yu, T ;Brown, SA ;Butterfield, DA ;Thompson, JS "D609 inhibits ionizing radiation-induced oxidative damage by acting as a potent antioxidant." The Journal of pharmacology and experimental therapeutics 298, 1 (2001): 103-9. Details. Full text
  • Pocernich, CB ;Cardin, AL ;Racine, CL ;Lauderback, CM ;Butterfield, DA "Glutathione elevation and its protective role in acrolein-induced protein damage in synaptosomal membranes: relevance to brain lipid peroxidation in neurodegenerative disease." Neurochemistry international 39, 2 (2001): 141-9. Details. Full text
  • Varadarajan, S ;Kanski, J ;Aksenova, M ;Lauderback, C ;Butterfield, DA "Different mechanisms of oxidative stress and neurotoxicity for Alzheimer's A beta(1--42) and A beta(25--35)." Journal of the American Chemical Society 123, 24 (2001): 5625-31. Details. Full text
  • Butterfield, DA ;Howard, BJ ;LaFontaine, MA "Brain oxidative stress in animal models of accelerated aging and the age-related neurodegenerative disorders, Alzheimer's disease and Huntington's disease." Current medicinal chemistry 8, 7 (2001): 815-28. Details. Full text
  • Kanski, J ;Lauderback, C ;Butterfield, DA "5-Aminosalicylic acid protection against oxidative damage to synaptosomal membranes by alkoxyl radicals in vitro." Neurochemical research 26, 1 (2001): 23-9. Details.
  • Butterfield, DA ;Kanski, J "Brain protein oxidation in age-related neurodegenerative disorders that are associated with aggregated proteins." Mechanisms of ageing and development 122, 9 (2001): 945-62. Details. Full text
  • Lauderback, CM ;Hackett, JM ;Keller, JN ;Varadarajan, S ;Szweda, L ;Kindy, M ;Markesbery, WR ;Butterfield, DA "Vulnerability of synaptosomes from apoE knock-out mice to structural and oxidative modifications induced by A beta(1-40): implications for Alzheimer's disease." Biochemistry 40, 8 (2001): 2548-54. Details. Full text
  • Yatin, SM ;Yatin, M ;Varadarajan, S ;Ain, KB ;Butterfield, DA "Role of spermine in amyloid beta-peptide-associated free radical-induced neurotoxicity." Journal of neuroscience research 63, 5 (2001): 395-401. Details. Full text
  • Butterfield, DA ;Drake, J ;Pocernich, C ;Castegna, A "Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid beta-peptide." Trends in molecular medicine 7, 12 (2001): 548-54. Details. Full text
  • Kanski, J ;Drake, J ;Aksenova, M ;Engman, L ;Butterfield, DA "Antioxidant activity of the organotellurium compound 3- 4-(N,N-dimethylamino)benzenetellurenyl propanesulfonic acid against oxidative stress in synaptosomal membrane systems and neuronal cultures." Brain research 911, 1 (2001): 12-21. Details. Full text
  • Lauderback, CM ;Hackett, JM ;Huang, FF ;Keller, JN ;Szweda, LI ;Markesbery, WR ;Butterfield, DA "The glial glutamate transporter, GLT-1, is oxidatively modified by 4-hydroxy-2-nonenal in the Alzheimer's disease brain: the role of Abeta1-42." Journal of neurochemistry 78, 2 (2001): 413-6. Details. Full text
  • Guo, Z ;Ersoz, A ;Butterfield, DA ;Mattson, MP "Beneficial effects of dietary restriction on cerebral cortical synaptic terminals: preservation of glucose and glutamate transport and mitochondrial function after exposure to amyloid beta-peptide, iron, and 3-nitropropionic acid." Journal of neurochemistry 75, 1 (2000): 314-20. Details. Full text
  • Lauderback, CM ;Breier, AM ;Hackett, J ;Varadarajan, S ;Goodlett-Mercer, J ;Butterfield, DA "The pyrrolopyrimidine U101033E is a potent free radical scavenger and prevents Fe(II)-induced lipid peroxidation in synaptosomal membranes." Biochimica et biophysica acta 1501, 2-3 (2000): 149-61. Details. Full text
  • Aksenov, M ;Aksenova, M ;Butterfield, DA ;Markesbery, WR "Oxidative modification of creatine kinase BB in Alzheimer's disease brain." Journal of neurochemistry 74, 6 (2000): 2520-7. Details. Full text
  • Keller, JN ;Lauderback, CM ;Butterfield, DA ;Kindy, MS ;Yu, J.;Markesbery, WR "Amyloid beta-peptide effects on synaptosomes from apolipoprotein E-deficient mice." Journal of neurochemistry 74, 4 (2000): 1579-86. Details. Full text
  • Pocernich, CB ;La Fontaine, M ;Butterfield, DA "In-vivo glutathione elevation protects against hydroxyl free radical-induced protein oxidation in rat brain." Neurochemistry international 36, 3 (2000): 185-91. Details. Full text
  • Wondrak, GT ;Varadarajan, S ;Butterfield, DA ;Jacobson, MK "Formation of a protein-bound pyrazinium free radical cation during glycation of histone H1." Free radical biology & medicine 29, 6 (2000): 557-67. Details. Full text
  • Yatin, SM ;Varadarajan, S ;Butterfield, DA "Vitamin E Prevents Alzheimer's Amyloid beta-Peptide (1-42)-Induced Neuronal Protein Oxidation and Reactive Oxygen Species Production." Journal of Alzheimer's disease : JAD 2, 2 (2000): 123-131. Details. Full text
  • Maragos, WF ;Jakel, R ;Chesnut, D ;Pocernich, CB ;Butterfield, DA ;St Clair, D.;Cass, WA "Methamphetamine toxicity is attenuated in mice that overexpress human manganese superoxide dismutase." Brain research 878, 1-2 (2000): 218-22. Details. Full text
  • Varadarajan, S ;Yatin, S ;Aksenova, M ;Butterfield, DA "Review: Alzheimer's amyloid beta-peptide-associated free radical oxidative stress and neurotoxicity." Journal of structural biology 130, 2-3 (2000): 184-208. Details. Full text
  • Koppal, T ;Drake, J ;Butterfield, DA "In vivo modulation of rodent glutathione and its role in peroxynitrite-induced neocortical synaptosomal membrane protein damage." Biochimica et biophysica acta 1453, 3 (1999): 407-11. Details. Full text
  • Varadarajan, S ;Yatin, S ;Kanski, J ;Jahanshahi, F ;Butterfield, DA "Methionine residue 35 is important in amyloid beta-peptide-associated free radical oxidative stress." Brain research bulletin 50, 2 (1999): 133-41. Details. Full text
  • Aksenova, MV ;Aksenov, MY ;Markesbery, WR ;Butterfield, DA "Aging in a dish: age-dependent changes of neuronal survival, protein oxidation, and creatine kinase BB expression in long-term hippocampal cell culture." Journal of neuroscience research 58, 2 (1999): 308-17. Details. Full text
  • Aksenov, MY ;Tucker, HM ;Nair, P ;Aksenova, MV ;Butterfield, DA ;Estus, S ;Markesbery, WR "The expression of several mitochondrial and nuclear genes encoding the subunits of electron transport chain enzyme complexes, cytochrome c oxidase, and NADH dehydrogenase, in different brain regions in Alzheimer's disease." Neurochemical research 24, 6 (1999): 767-74. Details.
  • Koppal, T ;Drake, J ;Yatin, S ;Jordan, B ;Varadarajan, S ;Bettenhausen, L ;Butterfield, DA "Peroxynitrite-induced alterations in synaptosomal membrane proteins: insight into oxidative stress in Alzheimer's disease." Journal of neurochemistry 72, 1 (1999): 310-7. Details. Full text
  • DeAtley, SM ;Aksenov, MY ;Aksenova, MV ;Jordan, B ;Carney, JM ;Butterfield, DA "Adriamycin-induced changes of creatine kinase activity in vivo and in cardiomyocyte culture." Toxicology 134, 1 (1999): 51-62. Details. Full text
  • Yatin, SM ;Yatin, M ;Aulick, T ;Ain, KB ;Butterfield, DA "Alzheimer's amyloid beta-peptide associated free radicals increase rat embryonic neuronal polyamine uptake and ornithine decarboxylase activity: protective effect of vitamin E." Neuroscience letters 263, 1 (1999): 17-20. Details. Full text
  • Yatin, SM ;Aksenov, M ;Butterfield, DA "The antioxidant vitamin E modulates amyloid beta-peptide-induced creatine kinase activity inhibition and increased protein oxidation: implications for the free radical hypothesis of Alzheimer's disease." Neurochemical research 24, 3 (1999): 427-35. Details.
  • DeAtley, SM ;Aksenov, MY ;Aksenova, MV ;Harris, B.;Hadley, R ;Harper, Cole ;Carney, JM ;Butterfield, DA "Antioxidants protect against reactive oxygen species associated with adriamycin-treated cardiomyocytes." Cancer letters 136, 1 (1999): 41-6. Details. Full text
  • Gabbita, SP ;Subramaniam, R ;Allouch, F ;Carney, JM ;Butterfield, DA "Effects of mitochondrial respiratory stimulation on membrane lipids and proteins: an electron paramagnetic resonance investigation." Biochimica et biophysica acta 1372, 2 (1998): 163-73. Details. Full text
  • Viswanath, S ;Wang, J.;Bachas, LG ;Butterfield, DA ;Bhattacharyya, D "Site-directed and random immobilization of subtilisin on functionalized membranes: activity determination in aqueous and organic media." Biotechnology and bioengineering 60, 5 (1998): 608-16. Details.
  • Koppal, T ;Subramaniam, R ;Drake, J ;Prasad, MR ;Dhillon, H ;Butterfield, DA "Vitamin E protects against Alzheimer's amyloid peptide (25-35)-induced changes in neocortical synaptosomal membrane lipid structure and composition." Brain research 786, 1-2 (1998): 270-3. Details. Full text
  • Aksenov, MY ;Tucker, HM ;Nair, P ;Aksenova, MV ;Butterfield, DA ;Estus, S ;Markesbery, WR "The expression of key oxidative stress-handling genes in different brain regions in Alzheimer's disease." Journal of molecular neuroscience : MN 11, 2 (1998): 151-64. Details. Full text
  • Butterfield, DA ;Koppal, T ;Howard, B ;Subramaniam, R ;Hall, N ;Hensley, K ;Yatin, S ;Allen, K ;Aksenov, M ;Aksenova, M ;Carney, J "Structural and functional changes in proteins induced by free radical-mediated oxidative stress and protective action of the antioxidants N-tert-butyl-alpha-phenylnitrone and vitamin E." Annals of the New York Academy of Sciences 854, (1998): 448-62. Details. Full text
  • Aksenova, MV ;Aksenov, MY ;Carney, JM ;Butterfield, DA "Protein oxidation and enzyme activity decline in old brown Norway rats are reduced by dietary restriction." Mechanisms of ageing and development 100, 2 (1998): 157-68. Details. Full text
  • Bruce-Keller, AJ ;Begley, JG ;Fu, W.;Butterfield, DA ;Bredesen, DE ;Hutchins, JB ;Hensley, K ;Mattson, MP "Bcl-2 protects isolated plasma and mitochondrial membranes against lipid peroxidation induced by hydrogen peroxide and amyloid beta-peptide." Journal of neurochemistry 70, 1 (1998): 31-9. Details. Full text
  • Yatin, SM ;Aksenova, M ;Aksenov, M ;Markesbery, WR ;Aulick, T ;Butterfield, DA "Temporal relations among amyloid beta-peptide-induced free-radical oxidative stress, neuronal toxicity, and neuronal defensive responses." Journal of molecular neuroscience : MN 11, 3 (1998): 183-97. Details. Full text
  • Subramaniam, R ;Koppal, T ;Green, M ;Yatin, S ;Jordan, B ;Drake, J ;Butterfield, DA "The free radical antioxidant vitamin E protects cortical synaptosomal membranes from amyloid beta-peptide(25-35) toxicity but not from hydroxynonenal toxicity: relevance to the free radical hypothesis of Alzheimer's disease." Neurochemical research 23, 11 (1998): 1403-10. Details.
  • DeAtley, SM ;Aksenov, MY ;Aksenova, MV ;Carney, JM ;Butterfield, DA "Adriamycin induces protein oxidation in erythrocyte membranes." Pharmacology & toxicology 83, 2 (1998): 62-8. Details.
  • Aksenov, MY ;Aksenova, MV ;Markesbery, WR ;Butterfield, DA "Amyloid beta-peptide (1-40)-mediated oxidative stress in cultured hippocampal neurons. Protein carbonyl formation, CK BB expression, and the level of Cu, Zn, and Mn SOD mRNA." Journal of molecular neuroscience : MN 10, 3 (1998): 181-92. Details. Full text
  • Begley, JG ;Butterfield, DA ;Keller, JN ;Koppal, T ;Drake, J ;Mattson, MP "Cryopreservation of rat cortical synaptosomes and analysis of glucose and glutamate transporter activities, and mitochondrial function." Brain research. Brain research protocols 3, 1 (1998): 76-82. Details. Full text
  • Hall, NC ;Carney, JM ;Plante, OJ ;Cheng, M.;Butterfield, DA "Effect of 2-cyclohexene-1-one-induced glutathione diminution on ischemia/reperfusion-induced alterations in the physical state of brain synaptosomal membrane proteins and lipids." Neuroscience 77, 1 (1997): 283-90. Details. Full text
  • Butterfield, DA ;Howard, BJ ;Yatin, S ;Allen, KL ;Carney, JM "Free radical oxidation of brain proteins in accelerated senescence and its modulation by N-tert-butyl-alpha-phenylnitrone." Proceedings of the National Academy of Sciences of the United States of America 94, 2 (1997): 674-8. Details. Full text
  • Aksenov, MY ;Aksenova, MV ;Carney, JM ;Butterfield, DA "Oxidative modification of glutamine synthetase by amyloid beta peptide." Free radical research 27, 3 (1997): 267-81. Details. Full text
  • Subramaniam, R ;Roediger, F ;Jordan, B ;Mattson, MP ;Keller, JN ;Waeg, G ;Butterfield, DA "The lipid peroxidation product, 4-hydroxy-2-trans-nonenal, alters the conformation of cortical synaptosomal membrane proteins." Journal of neurochemistry 69, 3 (1997): 1161-9. Details. Full text
  • Butterfield, DA ;Hensley, K ;Cole, P ;Subramaniam, R ;Aksenov, M ;Aksenova, M ;Bummer, PM ;Haley, BE ;Carney, JM "Oxidatively induced structural alteration of glutamine synthetase assessed by analysis of spin label incorporation kinetics: relevance to Alzheimer's disease." Journal of neurochemistry 68, 6 (1997): 2451-7. Details. Full text
  • Butterfield, DA "beta-Amyloid-associated free radical oxidative stress and neurotoxicity: implications for Alzheimer's disease." Chemical research in toxicology 10, 5 (1997): 495-506. Details. Full text
  • Howard, BJ ;Yatin, S ;Hensley, K ;Allen, KL ;Kelly, JP ;Carney, J ;Butterfield, DA "Prevention of hyperoxia-induced alterations in synaptosomal membrane-associated proteins by N-tert-butyl-alpha-phenylnitrone and 4-hydroxy-2,2,6,6-tetramethylpiperidin-1-oxyl (Tempol)." Journal of neurochemistry 67, 5 (1996): 2045-50. Details. Full text
  • Aksenov, MY ;Aksenova, MV ;Carney, JM ;Butterfield, DA "Alpha 1-antichymotrypsin interaction with A beta (1-42) does not inhibit fibril formation but attenuates the peptide toxicity." Neuroscience letters 217, 2-3 (1996): 117-20. Details. Full text
  • Clerici, WJ ;Hensley, K ;DiMartino, DL ;Butterfield, DA "Direct detection of ototoxicant-induced reactive oxygen species generation in cochlear explants." Hearing research 98, 1-2 (1996): 116-24. Details. Full text
  • Harris, ME ;Wang, Y.;Pedigo NW, Jr ;Hensley, K ;Butterfield, DA ;Carney, JM "Amyloid beta peptide (25-35) inhibits Na+-dependent glutamate uptake in rat hippocampal astrocyte cultures." Journal of neurochemistry 67, 1 (1996): 277-86. Details. Full text
  • Hensley, K ;Butterfield, DA ;Hall, N ;Cole, P ;Subramaniam, R ;Mark, R ;Mattson, MP ;Markesbery, WR ;Harris, ME ;Aksenov, M "Reactive oxygen species as causal agents in the neurotoxicity of the Alzheimer's disease-associated amyloid beta peptide." Annals of the New York Academy of Sciences 786, (1996): 120-34. Details. Full text
  • Aksenova, MV ;Aksenov, MY ;Butterfield, DA ;Carney, JM "alpha-1-antichymotrypsin interaction with A beta (1-40) inhibits fibril formation but does not affect the peptide toxicity." Neuroscience letters 211, 1 (1996): 45-8. Details. Full text
  • Aksenov, MY ;Aksenova, MV ;Butterfield, DA ;Hensley, K ;Vigo-Pelfrey, C ;Carney, JM "Glutamine synthetase-induced enhancement of beta-amyloid peptide A beta (1-40) neurotoxicity accompanied by abrogation of fibril formation and A beta fragmentation." Journal of neurochemistry 66, 5 (1996): 2050-6. Details. Full text
  • Houdi, AA ;Kottayil, S ;Crooks, PA ;Butterfield, DA "3-O-acetylmorphine-6-O-sulfate: a potent, centrally acting morphine derivative." Pharmacology, biochemistry, and behavior 53, 3 (1996): 665-71. Details. Full text
  • Hall, NC ;Carney, JM ;Cheng, M.;Butterfield, DA "Prevention of ischemia/reperfusion-induced alterations in synaptosomal membrane-associated proteins and lipids by N-tert-butyl-alpha-phenylnitrone and difluoromethylornithine." Neuroscience 69, 2 (1995): 591-600. Details. Full text
  • Harris, ME ;Hensley, K ;Butterfield, DA ;Leedle, RA ;Carney, JM "Direct evidence of oxidative injury produced by the Alzheimer's beta-amyloid peptide (1-40) in cultured hippocampal neurons." Experimental neurology 131, 2 (1995): 193-202. Details.
  • Harris, ME ;Carney, JM ;Cole, PS ;Hensley, K ;Howard, BJ ;Martin, L.;Bummer, P ;Wang, Y.;Pedigo NW, Jr ;Butterfield, DA "beta-Amyloid peptide-derived, oxygen-dependent free radicals inhibit glutamate uptake in cultured astrocytes: implications for Alzheimer's disease." Neuroreport 6, 14 (1995): 1875-9. Details.
  • Hall, NC ;Dempsey, RJ ;Carney, JM ;Donaldson, DL ;Butterfield, DA "Structural alterations in synaptosomal membrane-associated proteins and lipids by transient middle cerebral artery occlusion in the cat." Neurochemical research 20, 10 (1995): 1161-9. Details.
  • Hall, NC ;Carney, JM ;Cheng, MS ;Butterfield, DA "Ischemia/reperfusion-induced changes in membrane proteins and lipids of gerbil cortical synaptosomes." Neuroscience 64, 1 (1995): 81-9. Details. Full text
  • Aksenov, MYu ;Aksenova, MV ;Harris, ME ;Hensley, K ;Butterfield, DA ;Carney, JM "Enhancement of beta-amyloid peptide A beta(1-40)-mediated neurotoxicity by glutamine synthetase." Journal of neurochemistry 65, 4 (1995): 1899-902. Details. Full text
  • Mark, RJ ;Hensley, K ;Butterfield, DA ;Mattson, MP "Amyloid beta-peptide impairs ion-motive ATPase activities: evidence for a role in loss of neuronal Ca2+ homeostasis and cell death." The Journal of neuroscience : the official journal of the Society for Neuroscience 15, 9 (1995): 6239-49. Details. Full text
  • Cader, AA ;Butterfield, DA ;Watkins, BA ;CHung, BH ;Hennig, B "Electron spin resonance studies of fatty acid-induced alterations in membrane fluidity in cultured endothelial cells." The international journal of biochemistry & cell biology 27, 7 (1995): 665-73. Details. Full text
  • Hensley, K ;Howard, BJ ;Carney, JM ;Butterfield, DA "Membrane protein alterations in rodent erythrocytes and synaptosomes due to aging and hyperoxia." Biochimica et biophysica acta 1270, 2-3 (1995): 203-6. Details. Full text
  • Hensley, K ;Aksenova, M ;Carney, JM ;Harris, M ;Butterfield, DA "Amyloid beta-peptide spin trapping. II: Evidence for decomposition of the PBN spin adduct." Neuroreport 6, 3 (1995): 493-6. Details.
  • Hensley, K ;Aksenova, M ;Carney, JM ;Harris, M ;Butterfield, DA "Amyloid beta-peptide spin trapping. I: Peptide enzyme toxicity is related to free radical spin trap reactivity." Neuroreport 6, 3 (1995): 489-92. Details.
  • Hensley, K ;Carney, JM ;Mattson, MP ;Aksenova, M ;Harris, M ;Wu, JF ;Floyd, RA ;Butterfield, DA "A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease." Proceedings of the National Academy of Sciences of the United States of America 91, 8 (1994): 3270-4. Details. Full text
  • Butterfield, DA ;Lee, J. "Active site structure and stability of the thiol protease papain studied by electron paramagnetic resonance employing a methanethiosulfonate spin label." Archives of biochemistry and biophysics 310, 1 (1994): 167-71. Details. Full text
  • Alvarado, A ;Butterfield, DA ;Hennig, B "Disruption of endothelial barrier function: relationship to fluidity of membrane extracellular lamella." The International journal of biochemistry 26, 4 (1994): 575-81. Details.
  • Butterfield, DA ;Sun, B ;Bellary, S ;Arden, WA ;Anderson, KW "Effect of endotoxin on lipid order and motion in erythrocyte membranes." Biochimica et biophysica acta 1225, 2 (1994): 231-4. Details. Full text
  • Carney, JM ;Smith, CD ;Carney, AM ;Butterfield, DA "Aging- and oxygen-induced modifications in brain biochemistry and behavior." Annals of the New York Academy of Sciences 738, (1994): 44-53. Details. Full text
  • Hensley, K ;Carney, J ;Hall, N ;Shaw, W ;Butterfield, DA "Electron paramagnetic resonance investigations of free radical-induced alterations in neocortical synaptosomal membrane protein infrastructure." Free radical biology & medicine 17, 4 (1994): 321-31. Details. Full text
  • Butterfield, DA ;Trad, CH ;Hall, NC "Effects of dehydroabietic acid on the physical state of cytoskeletal proteins and the lipid bilayer of erythrocyte membranes." Biochimica et biophysica acta 1192, 2 (1994): 185-9. Details. Full text
  • Butterfield, DA ;Hensley, K ;Harris, M ;Mattson, M ;Carney, J "beta-Amyloid peptide free radical fragments initiate synaptosomal lipoperoxidation in a sequence-specific fashion: implications to Alzheimer's disease." Biochemical and biophysical research communications 200, 2 (1994): 710-5. Details. Full text
  • Lee, J.;Trad, CH ;Butterfield, DA "Electron paramagnetic resonance studies of the effects of methoxyacetic acid, a teratologic toxin, on human erythrocyte membranes." Toxicology 83, 1-3 (1993): 131-48. Details. Full text
  • Butterfield, DA ;Hensley, K ;Hall, N ;Umhauer, S ;Carney, J "Interaction of tacrine and velnacrine with neocortical synaptosomal membranes: relevance to Alzheimer's disease." Neurochemical research 18, 9 (1993): 989-94. Details.
  • Hensley, K ;Postlewaite, J ;Dobbs, P ;Butterfield, DA "Alteration of the erythrocyte membrane via enzymatic degradation of ankyrin (band 2.1): subcellular surgery characterized by EPR spectroscopy." Biochimica et biophysica acta 1145, 2 (1993): 205-11. Details. Full text
  • Yacko, MA ;Butterfield, DA "Spin-labeling studies of the conformation of the Ca(2+)-regulatory protein calmodulin in solution and bound to the membrane skeleton in erythrocyte ghosts: implications to transmembrane signaling." Biophysical journal 63, 2 (1992): 317-22. Details. Full text
  • Butterfield, DA ;Rangachari, A "Membrane-altering effects of velnacrine and N-methylacridinium: relevance to tacrine and Alzheimer's disease." Biochemical and biophysical research communications 185, 2 (1992): 596-603. Details. Full text
  • Yacko, MA ;Vanaman, TC ;Butterfield, DA "Spin labeling studies of wheat germ calmodulin in solution." Biochimica et biophysica acta 1064, 1 (1991): 7-12. Details. Full text
  • Chao, LN ;Butterfield, DA "The effects of the extracellular manganese concentration and variation of the interpulse delay time in the CPMG sequence on water exchange time across erythrocyte membranes." Biochimica et biophysica acta 1028, 3 (1990): 245-50. Details. Full text
  • Palmieri, DA ;Rangachari, A ;Butterfield, DA "Effects of domain-specific erythrocyte membrane modulators on acetylcholinesterase and NADH:cytochrome b5 reductase activities." Archives of biochemistry and biophysics 280, 1 (1990): 224-8. Details. Full text
  • Palmieri, DA ;Butterfield, DA "Structure-activity investigation of the alteration of the physical state of the skeletal network of proteins in human erythrocyte membranes induced by 9-amino-1,2,3,4-tetrahydroacridine." Biochimica et biophysica acta 1024, 2 (1990): 285-8. Details. Full text
  • Wyse, JW ;Franco, RS ;Barker, R ;Yacko, MA ;Butterfield, DA "Membrane processes associated with the osmotic-pulse incorporation of inositol hexaphosphate." Biochimica et biophysica acta 1022, 1 (1990): 87-92. Details. Full text
  • Wyse, JW ;Blank, ME ;Maynard, CL ;Diedrich, DF ;Butterfield, DA "Electron spin resonance investigation of the interaction of the anion and glucose transport inhibitor, p-azidobenzylphlorizin, with the human red cell membrane." Biochimica et biophysica acta 979, 1 (1989): 127-31. Details. Full text
  • Wyse, JW ;Butterfield, DA "Interaction of hemin with erythrocyte membranes: alterations in the physical state of the major sialoglycoprotein." Biochimica et biophysica acta 979, 1 (1989): 121-6. Details. Full text
  • Palmieri, DA ;Jacob, RJ ;Butterfield, DA "Morphological alterations in erythrocyte membranes induced by 9-amino-1,2,3,4-tetrahydroacridine and 9-aminoacridine." Biochemical and biophysical research communications 163, 3 (1989): 1351-5. Details. Full text
  • Wyse, JW ;Butterfield, DA "Electron spin resonance and biochemical studies of the interaction of the polyamine, spermine, with the skeletal network of proteins in human erythrocyte membranes." Biochimica et biophysica acta 941, 2 (1988): 141-9. Details. Full text
  • Sultana, R.;Butterfield, DA "Regional expression of key cell cycle proteins in brain from subjects with amnestic mild cognitive impairment." Neurochemical research 32, 4-5 (1969): 655-62. Details. Full text
  • Zhuang, P ;Butterfield, DA "Spin labeling and kinetic studies of a membrane-immobilized proteolytic enzyme." Biotechnology progress 8, 3 (1969): 204-10. Details. Full text
  • Perluigi, M.;Di Domenico, F.;Fiorini, A.;Cocciolo, A.;Giorgi, A.;Foppoli, C.;Butterfield, DA ;Giorlandino, M.;Giorlandino, C.;Schininà, ME ;Coccia, R. (1969): Details.
  • Mancuso, C.;Siciliano, R.;Barone, E.;Butterfield, DA ;Preziosi, P. (1969): Details. Full text
  • Drake, J ;Link, CD ;Butterfield, DA "Oxidative stress precedes fibrillar deposition of Alzheimer's disease amyloid beta-peptide (1-42) in a transgenic Caenorhabditis elegans model." Neurobiology of aging 24, 3 (1969): 415-20. Details. Full text
  • Butterfield, DA ;Bush, AI "Alzheimer's amyloid beta-peptide (1-42): involvement of methionine residue 35 in the oxidative stress and neurotoxicity properties of this peptide." Neurobiology of aging 25, 5 (1969): 563-8. Details. Full text
  • Aksenova, MV ;Aksenov, MY ;Payne, RM ;Trojanowski, JQ ;Schmidt, ML ;Carney, JM ;Butterfield, DA ;Markesbery, WR "Oxidation of cytosolic proteins and expression of creatine kinase BB in frontal lobe in different neurodegenerative disorders." Dementia and geriatric cognitive disorders 10, 2 (1969): 158-65. Details. Full text
  • Butterfield, DA ;Castegna, A ;Lauderback, CM ;Drake, J "Evidence that amyloid beta-peptide-induced lipid peroxidation and its sequelae in Alzheimer's disease brain contribute to neuronal death." Neurobiology of aging 23, 5 (1969): 655-64. Details. Full text
  • Barone, E.;Di Domenico, F.;Sultana, R.;Coccia, R.;Mancuso, C.;Perluigi, M.;Butterfield, DA "Heme oxygenase-1 posttranslational modifications in the brain of subjects with Alzheimer disease and mild cognitive impairment." Free radical biology & medicine 52, 11-12 (1969): 2292-301. Details. Full text
  • Chao, LN ;Yacko, MA ;Ping, ZA ;Butterfield, DA "Water transport across red-cell membranes following reductive methylation of the major transmembrane protein, Band 3: implications to increased divalent cation membrane permeability." Membrane biochemistry 9, 2 (1969): 107-16. Details.
  • Butterfield, DA ;Hall, NC ;Cross, SJ "Effects of beta-(N-methylamino)-L-alanine on cytoskeletal proteins of erythrocyte membranes." Chemical research in toxicology 6, 4 (1969): 417-20. Details.
  • Ganapathi-Desai, S ;Butterfield, DA ;Bhattacharyya, D "Kinetics and active fraction determination of a protease enzyme immobilized on functionalized membranes: mathematical modeling and experimental results." Biotechnology progress 14, 6 (1969): 865-73. Details. Full text
  • Poon, HF ;Calabrese, V.;Calvani, M ;Butterfield, DA "Proteomics analyses of specific protein oxidation and protein expression in aged rat brain and its modulation by L-acetylcarnitine: insights into the mechanisms of action of this proposed therapeutic agent for CNS disorders associated with oxidative..." Antioxidants & redox signaling 8, 3-4 (1969): 381-94. Details. Full text
  • Butterfield, DA ;Dalle-Donne, I "Redox proteomics: from protein modifications to cellular dysfunction and disease." Mass spectrometry reviews 33, 1 (1969): 1-6. Details. Full text
  • Sultana, R.;Perluigi, M.;Butterfield, DA "Protein oxidation and lipid peroxidation in brain of subjects with Alzheimer's disease: insights into mechanism of neurodegeneration from redox proteomics." Antioxidants & redox signaling 8, 11-12 (1969): 2021-37. Details. Full text
  • Yatin, SM ;Varadarajan, S ;Link, CD ;Butterfield, DA "In vitro and in vivo oxidative stress associated with Alzheimer's amyloid beta-peptide (1-42)" Neurobiology of aging 20, 3 (1969): 325-30; discussion 339-42. Details. Full text
  • Ranjan, D ;Chen, C.;Johnston, TD ;Jeon, H ;Ibrahim, M ;Drake, J ;Butterfield, DA "Stimulation of Epstein-Barr virus-infected human B cell growth by physiological concentrations of 4-hydroxynonenal." Cell biochemistry and function 24, 2 (1969): 147-52. Details.
  • Butterfield, DA ;Gu, L ;Di Domenico, F.;Robinson, RA "Mass spectrometry and redox proteomics: applications in disease." Mass spectrometry reviews 33, 4 (1969): 277-301. Details. Full text
  • Sultana, R.;Reed, T ;Perluigi, M.;Coccia, R.;Pierce, WM ;Butterfield, DA "Proteomic identification of nitrated brain proteins in amnestic mild cognitive impairment: a regional study." Journal of cellular and molecular medicine 11, 4 (1969): 839-51. Details. Full text
  • Sultana, R.;Mecocci, P.;Mangialasche, F.;Cecchetti, R.;Baglioni, M.;Butterfield, DA "Increased protein and lipid oxidative damage in mitochondria isolated from lymphocytes from patients with Alzheimer's disease: insights into the role of oxidative stress in Alzheimer's disease and initial investigations into a potential biomarker for..." Journal of Alzheimer's disease : JAD 24, 1 (0): 77-84. Details. Full text
  • Lauderback, CM ;Harris-White, ME ;Wang, Y.;Pedigo NW, Jr ;Carney, JM ;Butterfield, DA "Amyloid beta-peptide inhibits Na+-dependent glutamate uptake." Life sciences 65, 18-19 (0): 1977-81. Details. Full text
  • Butterfield, DA ;Martin, L.;Carney, JM ;Hensley, K "A beta (25-35) peptide displays H2O2-like reactivity towards aqueous Fe2+, nitroxide spin probes, and synaptosomal membrane proteins." Life sciences 58, 3 (0): 217-28. Details. Full text
  • Tramutola, A ;Di Domenico, F.;Barone, E.;Perluigi, M.;Butterfield, DA "It Is All about (U)biquitin: Role of Altered Ubiquitin-Proteasome System and UCHL1 in Alzheimer Disease." Oxidative medicine and cellular longevity 2016, (0): 2756068. Details. Full text
  • Butterfield, DA ;Howard, B ;Yatin, S ;Koppal, T ;Drake, J ;Hensley, K ;Aksenov, M ;Aksenova, M ;Subramaniam, R ;Varadarajan, S ;Harris-White, ME ;Pedigo NW, Jr ;Carney, JM "Elevated oxidative stress in models of normal brain aging and Alzheimer's disease." Life sciences 65, 18-19 (0): 1883-92. Details. Full text
  • Poon, HF ;Castegna, A ;Farr, SA ;Thongboonkerd, V ;Lynn, BC ;Banks, WA ;Morley, JE ;Klein, JB ;Butterfield, DA "Quantitative proteomics analysis of specific protein expression and oxidative modification in aged senescence-accelerated-prone 8 mice brain." Neuroscience 126, 4 (0): 915-26. Details. Full text
  • Carney, JM ;Hall, NC ;Cheng, M.;Wu, J.;Butterfield, DA "Protein and lipid oxidation following ischemia/reperfusion injury, the role of polyamines: an electron paramagnetic resonance analysis." Advances in neurology 71, (0): 259-68; discussion 268-9. Details.
  • Sultana, R.;Perluigi, M.;Butterfield, DA "Proteomics identification of oxidatively modified proteins in brain." Methods in molecular biology (Clifton, N.J.) 564, (0): 291-301. Details. Full text
  • Butterfield, DA ;Palmieri, EM ;Castegna, A "Clinical implications from proteomic studies in neurodegenerative diseases: lessons from mitochondrial proteins." Expert review of proteomics 13, 3 (0): 259-74. Details. Full text
  • Gabbita, SP ;Butterfield, DA ;Hensley, K ;Shaw, W ;Carney, JM "Aging and caloric restriction affect mitochondrial respiration and lipid membrane status: an electron paramagnetic resonance investigation." Free radical biology & medicine 23, 2 (0): 191-201. Details. Full text
  • Aluise, CD ;Sultana, R.;Tangpong, J ;Vore, M.;St Clair, D.;Moscow, JA ;Butterfield, DA "Chemo brain (chemo fog) as a potential side effect of doxorubicin administration: role of cytokine-induced, oxidative/nitrosative stress in cognitive dysfunction." Advances in experimental medicine and biology 678, (0): 147-56. Details. Full text
  • Sultana, R.;Butterfield, DA "Slot-blot analysis of 3-nitrotyrosine-modified brain proteins." Methods in enzymology 440, (0): 309-16. Details. Full text
  • Butterfield, DA ;Boyd-Kimball, D "Oxidative Stress, Amyloid-β Peptide, and Altered Key Molecular Pathways in the Pathogenesis and Progression of Alzheimer's Disease." Journal of Alzheimer's disease : JAD 62, 3 (0): 1345-1367. Details. Full text
  • Wyse, JW ;Franco, RS ;Barker, R ;Butterfield, DA "Erythrocyte membrane skeletal protein alterations induced by polyanions: implications to the osmotic-pulse incorporation of inositol hexaphosphate." Progress in clinical and biological research 292, (0): 65-75. Details.
  • Sultana, R.;Reed, T ;Butterfield, DA "Detection of 4-hydroxy-2-nonenal- and 3-nitrotyrosine-modified proteins using a proteomics approach." Methods in molecular biology (Clifton, N.J.) 519, (0): 351-61. Details. Full text
  • Butterfield, DA ;Yatin, SM ;Varadarajan, S ;Koppal, T "Amyloid beta-peptide-associated free radical oxidative stress, neurotoxicity, and Alzheimer's disease." Methods in enzymology 309, (0): 746-68. Details. Full text
  • Hardas, SS ;Sultana, R.;Clark, AM ;Beckett, TL ;Szweda, LI ;Murphy, MP ;Butterfield, DA "Oxidative modification of lipoic acid by HNE in Alzheimer disease brain." Redox biology 1, (0): 80-5. Details. Full text
  • Butterfield, DA ;Hardas, SS ;Lange, ML "Oxidatively modified glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and Alzheimer's disease: many pathways to neurodegeneration." Journal of Alzheimer's disease : JAD 20, 2 (0): 369-93. Details. Full text
  • Butterfield, DA ;Sultana, R. "Identification of 3-nitrotyrosine-modified brain proteins by redox proteomics." Methods in enzymology 440, (0): 295-308. Details. Full text
  • Sultana, R.;Butterfield, DA "Oxidative modification of brain proteins in Alzheimer's disease: perspective on future studies based on results of redox proteomics studies." Journal of Alzheimer's disease : JAD 33 Suppl 1, (0): S243-51. Details. Full text
  • Hayslip, J ;Dressler, EV ;Weiss, H ;Taylor, TJ ;Chambers, M ;Noel, T.;Miriyala, S.;Keeney, JT ;Ren, X ;Sultana, R.;Vore, M.;Butterfield, DA ;St Clair, D.;Moscow, JA "Plasma TNF-α and Soluble TNF Receptor Levels after Doxorubicin with or without Co-Administration of Mesna-A Randomized, Cross-Over Clinical Study." PloS one 10, 4 (0): e0124988. Details. Full text
  • Bellary, SS ;Anderson, KW ;Arden, WA ;Butterfield, DA "Effect of lipopolysaccharide on the physical conformation of the erythrocyte cytoskeletal proteins." Life sciences 56, 2 (0): 91-8. Details. Full text
  • Chao, LN ;Shaffer, LM ;Butterfield, DA "The effect of hematocrit on water transport across human erythrocyte membranes: a 1H-T2 NMR study." Progress in clinical and biological research 292, (0): 45-52. Details.
  • Tramutola, A ;Lanzillotta, C ;Barone, E.;Arena, A ;Zuliani, I ;Mosca, L ;Blarzino, C ;Butterfield, DA ;Perluigi, M.;Di Domenico, F. "Intranasal rapamycin ameliorates Alzheimer-like cognitive decline in a mouse model of Down syndrome." Translational neurodegeneration 7, (0): 28. Details. Full text
  • Triplett, JC ;Swomley, AM ;Cai, J.;Klein, JB ;Butterfield, DA "Quantitative phosphoproteomic analyses of the inferior parietal lobule from three different pathological stages of Alzheimer's disease." Journal of Alzheimer's disease : JAD 49, 1 (0): 45-62. Details. Full text
  • Butterfield, DA ;Boyd-Kimball, D "Proteomics analysis in Alzheimer's disease: new insights into mechanisms of neurodegeneration." International review of neurobiology 61, (0): 159-88. Details. Full text
  • Palmieri, DA ;Butterfield, DA "Effects of 9-amino-1,2,3,4-tetrahydroacridine (THA), a potential drug for treatment of Alzheimer's disease, on the physical state of human erythrocyte membranes." Progress in clinical and biological research 292, (0): 419-24. Details.
  • Di Domenico, F.;Pupo, G ;Mancuso, C.;Barone, E.;Paolini, F ;Arena, A ;Blarzino, C ;Schmitt, FA ;Head, E.;Butterfield, DA ;Perluigi, M. "Bach1 overexpression in Down syndrome correlates with the alteration of the HO-1/BVR-a system: insights for transition to Alzheimer's disease." Journal of Alzheimer's disease : JAD 44, 4 (0): 1107-20. Details. Full text
  • Hensley, K ;Butterfield, DA ;Mattson, M ;Aksenova, M ;Harris, M ;Wu, JF ;Floyd, R ;Carney, J "A model for beta-amyloid aggregation and neurotoxicity based on the free radical generating capacity of the peptide: implications of "molecular shrapnel" for Alzheimer's disease." Proceedings of the Western Pharmacology Society 38, (0): 113-20. Details.
  • Butterfield, DA "ESR studies of transmembrane signaling processes: modulation of skeletal protein-protein interactions and their influence on the physical state of cell-surface carbohydrates in human erythrocyte membranes." Progress in clinical and biological research 292, (0): 53-64. Details.
  • Sultana, R.;Butterfield, DA "Role of oxidative stress in the progression of Alzheimer's disease." Journal of Alzheimer's disease : JAD 19, 1 (0): 341-53. Details. Full text
  • Wilson, EN ;Carmo, Do ;Iulita, MF ;Hall, H ;Austin, GL ;Jia, DT ;Malcolm, JC ;Foret, MK ;Marks, AR ;Butterfield, DA ;Cuello, AC "Microdose Lithium NP03 Diminishes Pre-Plaque Oxidative Damage and Neuroinflammation in a Rat Model of Alzheimer's-like Amyloidosis." Current Alzheimer research 15, 13 (0): 1220-1230. Details. Full text
  • Butterfield, DA ;Palmieri, DA "Spin-labelling studies of the interaction of 9-amino-1,2,3,4-tetrahydroacridine (THA), a proposed drug for the treatment of Alzheimer's disease, with erythrocyte membranes." Free radical research communications 9, 3-6 (0): 361-6. Details.
  • Butterfield, DA "Perspectives on Oxidative Stress in Alzheimer's Disease and Predictions of Future Research Emphases." Journal of Alzheimer's disease : JAD 64, s1 (0): S469-S479. Details. Full text
  • Butterfield, DA ;Yatin, SM ;Link, CD "In vitro and in vivo protein oxidation induced by Alzheimer's disease amyloid beta-peptide (1-42)." Annals of the New York Academy of Sciences 893, (0): 265-8. Details. Full text
  • Butterfield, DA ;Rangachari, A "Acetylcarnitine increases membrane cytoskeletal protein-protein interactions." Life sciences 52, 3 (0): 297-303. Details. Full text
  • Butterfield, DA ;Pocernich, CB "The glutamatergic system and Alzheimer's disease: therapeutic implications." CNS drugs 17, 9 (0): 641-52. Details. Full text
  • Sultana, R.;Newman, SF ;Huang, Q.;Butterfield, DA "Detection of carbonylated proteins in two-dimensional sodium dodecyl sulfate polyacrylamide gel electrophoresis separations." Methods in molecular biology (Clifton, N.J.) 476, (0): 153-63. Details. Full text
  • Barone, E.;Di Domenico, F.;Cenini, G.;Sultana, R.;Coccia, R.;Preziosi, P.;Perluigi, M.;Mancuso, C.;Butterfield, DA "Oxidative and nitrosative modifications of biliverdin reductase-A in the brain of subjects with Alzheimer's disease and amnestic mild cognitive impairment." Journal of Alzheimer's disease : JAD 25, 4 (0): 623-33. Details. Full text
  • Butterfield, DA ;Koppal, T ;Subramaniam, R ;Yatin, S "Vitamin E as an antioxidant/free radical scavenger against amyloid beta-peptide-induced oxidative stress in neocortical synaptosomal membranes and hippocampal neurons in culture: insights into Alzheimer's disease." Reviews in the neurosciences 10, 2 (0): 141-9. Details. Full text
  • Pocernich, CB ;Butterfield, DA "Acrolein inhibits NADH-linked mitochondrial enzyme activity: implications for Alzheimer's disease." Neurotoxicity research 5, 7 (0): 515-20. Details. Full text
  • Tramutola, A ;Pupo, G ;Di Domenico, F.;Barone, E.;Arena, A ;Lanzillotta, C ;Brokeaart, D ;Blarzino, C ;Head, E.;Butterfield, DA ;Perluigi, M. "Activation of p53 in Down Syndrome and in the Ts65Dn Mouse Brain is Associated with a Pro-Apoptotic Phenotype." Journal of Alzheimer's disease : JAD 52, 1 (0): 359-371. Details. Full text
  • Aluise, CD ;Robinson, RA ;Cai, J.;Pierce, WM ;Markesbery, WR ;Butterfield, DA "Redox proteomics analysis of brains from subjects with amnestic mild cognitive impairment compared to brains from subjects with preclinical Alzheimer's disease: insights into memory loss in MCI." Journal of Alzheimer's disease : JAD 23, 2 (0): 257-69. Details. Full text
  • Boyd-Kimball, D ;Sultana, R.;Poon, HF ;Lynn, BC ;Casamenti, F ;Pepeu, G ;Klein, JB ;Butterfield, DA "Proteomic identification of proteins specifically oxidized by intracerebral injection of amyloid beta-peptide (1-42) into rat brain: implications for Alzheimer's disease." Neuroscience 132, 2 (0): 313-24. Details. Full text
  • Butterfield, DA "William R. Markesbery, M.D.: A legacy of excellence in Alzheimer's disease research and a life well-lived." Journal of Alzheimer's disease : JAD 20, 1 (0): 3-4. Details. Full text
  • Butterfield, DA ;Sultana, R. "Methionine-35 of aβ(1-42): importance for oxidative stress in Alzheimer disease." Journal of amino acids 2011, (0): 198430. Details. Full text
* Publications are automatically pulled from pubmed.gov based on a user-specific query. Results may include incorrect citations. See: Tutorial on improving PubMed results.
Honors & Awards

HONORS AND AWARDS

  • Phi Beta Kappa Honorary Society, 1968
  • Phi Kappa Phi Honorary Society, 1967
  • NIH Biomedical Science Research Award, 1972
  • Graduate School Research Award (Duke University), 1972
  • NIH Postdoctoral Fellowship, 1974
  • University of Kentucky Research Foundation Faculty Research Award, 1979
  • Awarded University of Kentucky Research Professorship, 1980 81
  • Appointed to Biophysics and Biophysical Chemistry Study Section A of the National Institutes of Health (NIGMS), Spring 1980 Meeting
  • Appointed to National Institute of Health Site Visit Study Section, Summer 1980
  • Invited Speaker, Gordon Research Conference on Magnetic Resonance in Biology and Medicine, 1980
  • Consultant, National Institute on Aging, NIH Site Visit, "Alzheimer's Disease Center," May, 1987
  • Consultant, National Heart, Lung and Blood Institute, NIH Site Visit, "Comprehensive Sickle Cell Disease Center," May, 1987
  • Special Faculty Grant, 1988 1990
  • Editorial Board Member, Journal of Membrane Science, 1989 present
  • Finalist, College of Arts and Sciences Distinguished Professorship, 1990, 1991
  • Dow Chemical Distinguished Lectureship, University of D etroit, 1995
  • The Honorable Order of Kentucky Colonels, 1995
  • Consultant, National Institute on Aging, NIH Reverse Site Visit on "β-Amyloid Program Project," 1996
  • Recipient, Distinguished University Scientist Award from the Kentucky Academy of Science, 1996
  • Consultant, National Science Foundation, Small Business Investigative Research Panel, 1996
  • Consultant, national Aeronautics and Space Administration, Shuttle Experiment Panel, 1997
  • Recipient, William B. Sturgill Award for Graduate Education, 1997
  • Recipient, Southern Chemist Award from the American Chemical Society, Memphis Section, 1997
  • Recipient, Presidential Award for Excellence in Science, Mathematics and Engineering Mentoring, Presented by President Clinton in the White House , 1998.
  • Appointed as Senior Associate Editor, Journal of Alzheimer's Disease
  • Consultant, National Institute on Aging, NIH Site Visit on "Alzheimer's Disease PPG," 1998
  • Consultant, National Institute on Aging, NIH Site Visit on "Alzheimer's Disease PPG," 1999
  • Consultant, National Institute on Aging, NIH Site Visit on "Alzheimer's Disease PPG," 2000
  • Consultant, National Institute on Aging, NIH Site Visit on "Prion Disorders," 2002
  • Consultant, National Institute on Aging, NIH Site Visit on "Alzheimer's Disease," 2002
  • Consultant, National Institute on Aging, NIH Site Visit on "Alzheimer's Disease," 2003
  • Consultant, National Institute on Aging, NIH Site Visit on "Alzheimer's Disease," 2004
  • Consultant, National Institute on Aging, NIH Site Visit on "Alzheimer's Disease," 2005
  • Consultant, National Institute on Aging, NIH Site Visit on "Alzheimer's Disease," 2007
  • Recipient, Honorary Doctor of Science Degree, University of Maine, Commencement, 2002
  • Alumni Association Endowed Professor of Biological Chemistry, University of Kentucky, 2002-present
  • Member, Scientific Advisory Board for Neurobiology, National University of Singapore (One of only 4 international members)
  • Ad-hoc Member, Study Section on Conflict of Interest, NIGMS, NIH
  • Ad-hoc Member, Study Section on Synapses, NINDS, NIH
  • Recipient, Award for Most Outstanding PhD Committee Member for Prince of Songkla University, Thailand, 2007
  • International Member, Scientific Review Panel, Ministry of Education, for the Government of Singapore, 2006-present
  • Permanent Member, NIH Study Section on Neural Oxidative and Metabolic Death, 2008-2012
  • Invited Speaker, Gordon Research Conference on Oxygen Radicals, 2010
  • Recipient, Albert D. and Elizabeth H. Kirwan Memorial Prize for Excellence in Research, 2010
  • Member, Editorial Board, Neuroproteomics
  • Selected as a Fellow of the Society for Free Radical Biology and Medicine, 2012 (one of only 28 Fellows in the world).
  • Recipient, 2013 Discovery Award from the Society for Free Radical Biology and Medicine
  • 2014: Editorial Board Member, Pharmacological Research
  • 2014: Recipient, Alkmeon International Prize for Progress in Science, presented at the University of Rome, Tor Vergata in Rome, Italy
  • Member, Editorial Board, Frontiers in Pharmacology
  •  2014: Recipient, Society for Free Radical Biology and Medicine Mentoring Excellence Award
  •  2014: Elected Editorial Board Member, Free Radical Biology and Medicine

 

Publications

658. D.A. Butterfield, M. Bing, Q. Peng, S. Hardas, J. Unrine, E. Grulke, U. Graham, M. Tseng, J. Cai, J.B. Klein, D. Pears, R.A. Yokel, and R. Sultana, “Identification of Serum or Plasma Proteins Bound to Nanoceria Using a Proteomics Approach: Insights into Potential Pathways by which Ceria NPs May Exert Beneficial or Deleterious Effects in vivo,” Manuscript in Preparation (2018).

657. X. Ren, J. Keeney, S. Miriyala, T. Noel, D. Powell, S. Bondada, D. St. Clair, and D.A. Butterfield, “The Triangle of Death of Neurons, Oxidative Damage, Mitochondrial Dysfunction, and Loss of Choline-Containing Biomolecules, in Brains of Mice Treated with Doxorubicin: Advanced Insights into Mechanisms of Chemotherapy Induced Cognitive Impairment (“Chemobrain”) Involving TNF-alpha,” Submitted for Publication (2018).

656. A. Tramutola, G. Abate, C. Lanzillotta, F. Triani, E. Barone, F. Iavarone, F. Vincenzoni, M. Castagnola, M. Marziano, M. Memo, E. Garrafa, D.A. Butterfield, M. Perluigi, F. Di Domenico, and Daniela Uberti, “Redox Proteomics Analysis of 3-NT-modified Proteins in T Cells from Alzheimer Disease Patients: Involvement in Immunosenescence and/or Pathology Prediction,” Submitted for Publication (2018).

655. A.Tramutola, C. Lanzillotta, E. Barone, A. Arena, I. Zuliani, L. Mosca, C. Blarzino, D.A. Butterfield, M. Perluigi, and F. Di Domenico, “Intranasal Rapamycin Ameliorates Alzheimer-like Cognitive Decline in a Mouse Model of Down Syndrome,” Submitted (2018).

654. D.A. Butterfield and B. Halliwell, “Oxidative Stress, Glucose Dysmetabolism and Alzheimer Disease,” Submitted (2018).

653. T. Salameh, W. Mortell, A. Logsdon, D.A. Butterfield, and W. Banks, “Disruption of the Hippocampal and Hypthalamic Blood-brain Barrier in a Diet-induced Obese Model of Type II Diabetes: Prevention and Treatment by the Mitochondrial Carbonic Anhydrase Inhibitor, Topiramate,” Submitted (2018).

652. E.N. Wilson, S. Do Carmo, M.F. Iulita, H. Hall, G.L. Austin, D.T. Jia, J.C. Malcolm, D.A. Butterfield, and C.Cuello, “Microdose Lithium NP03 Diminishes Pre-Plaque Oxidative Damage and Neuroinflammation in Alzheimer rat,” Submitted (2018).

651. L. Liu, L. Qi, T. Knifley, D. Piecoro, P. Rychahou, J. Liu, M. Mitov, C. Wang, J. Wu, H. Weiss, D.A. Butterfield, B. M. Evers, K. O’Connor, and M. Chen, “S100A4 Enhances Cellular Respiration to Promote Invasive and Metastatic Capacity of Lung Cancer Cells Through Upregulation of NDUFS2,” Submmited (2018).

650. D.A. Butterfield and D. Boyd-Kimball, “Redox Proteomics and Amyloid β-Peptide: Insights into Alzheimer Disease,” J. Neurochem., Minor Revision (2018).

649. E. Barone, A. Tramutola, F. Triani, S. Calcagnini, F. Di Domenico, C. Ripoli, S. Gaetani, C. Grassi, D.A. Butterfield, T. Cassano, and M. Perluigi, “Biliverdin Reductase-A Mediates the Beneficial Effects of Intranasal Insulin in Alzheimer Disease” Molecular Neurobiology, in press (2018).

648. A. Tramutola, N. Sharma, E. Barone, C. Lanzillotta, A. Castellani, F. Iavarone, F. Vincenoni, M. Castagnola, D.A. Butterfield, S. Gaetani, T. Cassano, M. Perluigi, and F. Di Domenico, “Proteomic Identification of Altered Protein O-GlcNAcylation Profile in a Triple Transgenic Mouse Model of Alzheimer’s Disease. Biochimica et Biophysica Acta—Molecular Basis of Disease 1864, 3309-3321 (2018).

647. F. Triani, A. Tramutola, F. Di Domenico, N. Sharma, D.A Butterfield, E. Head, M. Perluigi, and E. Barone, “Biliverdin Reductase-A Impairment Links Brain Insulin Resistance with Increased A Production in an Animal Model of Aging: Implications for Alzheimer Disease,” Biochimica et Biophysica Acta—Molecular Basis of Disease 1864, 3181-3194 (2018).

646. J.T.R. Keeney, X. Ren, G. Warrier, T. Noel, D.K. Powell, J.M. Brelsfoard, R. Sultana, K.E. Saatman, D.K. St. Clair, and D.A. Butterfield, “Doxorubicin-induced Elevated Oxidative Stress and Neurochemical Alterations in Brain and Cognitive Decline: Protection by MESNA and Insights into Mechanisms of Chemotherapy-induced Cognitive Impairment (“Chemobrain”),” Oncotarget 9, 30324-30339 (2018).

645. A. Tramutola, F. Triani, F. Di Domenico, E. Barone, M. Perluigi, and D.A. Butterfield, “Poly-ubiquitin Profile in Alzheimer Disease Brain,” Neurobiology of Disease 118, 129-141 (2018).

644. D.A. Butterfield, “Perspectives on Oxidative Stress in Alzheimer Disease and Predictors of Future Research Emphases,” Journal of Alzheimer’s Disease 64, S469-S479 (2018).

643. C. Yarana, D. Carroll, J. Chen, L. Chaiswing, Y. Zhao, T. Noel, M. Alstott, Y. Bae, E. Dressler, J. Moscow, D.A. Butterfield, H. Zhu, and D. St. Clair, “Extracellular Vesciles Released by Cardiomyocytes in a Doxorubicin-Induced Cardiac Injury Mouse Model Contain Protein Biomarkers of Early Cardiac Injury,” Clinical Cancer Research 24, 1644-1553 (2018).

642. D.A. Butterfield and D. Boyd-Kimball, “Oxidative Stress, Amyloid beta-Peptide, and Altered Key Molecular Pathways in the Pathogenesis and Progression of Alzheimer Disease,” Journal of Alzheimer’s Disease 62, 1345-1367 (2018).

641. F. Di Domenico, A. Tramutola, C. Foppoli, E. Head, M. Perluigi, and D.A. Butterfield, “mTOR in Down Syndrome: Role in A and Tau Neuropathology and Transition to Alzheimer Disease-like Dementia,” Free Radical Biology & Medicine 114, 94-101 (2018).

640. E. Barone, A. Arena, E. Head, D.A. Butterfield, M. Perluigi, “Disturbance of Redox Homestasis in Down Syndrome: Role of Iron Dysmetabolism,” Free Radical Biology & Medicine 114, 84-93 (2018).

639. D.A. Butterfield and M. Perluigi, “Down Syndrome: From Development to Adult Life to Alzheimer Disease,” Free Radical Biology and Medicine 114, 1-2 (2018).

638. D. Arndt, E.K. Oostveen, J. Triplett, D.A. Butterfield, O.V. Tsyusko, B.E. Collin, D.L. Starnes, J. Cai, J.B. Klein, R. Nass, and J.M. Unrine, “The Role of Charge in the Toxicity of Polymer-coated Cerium Oxide Nanomaterials to Caenorhabditis elegans,” Comp Biochem Physiol C: Toxicol Pharmacol 201, 1-10 (2017).

637. T.C. Thomas, J.A. Beitchman, F. Pomerleau, T. Noel, P. Jungsuwadee, D.A. Butterfield, D.K. St. Clair, M. Vore, G.A. Gerhardt, “Acute Treatment with Doxorubicin Affects Glutamate Neurotransmission in the Mouse Frontal Cortex and Hippocampus,” Brain Research, 1672, 10-17 (2017).

636. V. Vilchez. L. Turcios, D.A. Butterfield, M.I. Mitov, C.L. Coquillard, J.A. Brandon, V. Cornea, R. Gedaly, and F. Marti, “Evidence of the Immunomodulatory Role of Dual PI3K/mTOR Inhibitors in Transplantation: An Experimental Study in Mice,” Transplant International 30, 1061-1074 (2017).

635. J. Zhang and D.A. Butterfield, “Oxidative Stress and Neurodegeneration,” Brain Research Bullein 133, 1-3 (2017).

634. L. Turcios, V. Vilchez, L.F. Acosta, P. Poyil, D.A. Butterfield, M. Mitov, F. Marti and R. Gedaly, “Sorafenib and FH535 in Combination Act Synergistically on Hepatocellular Carcinoma by Targeting Cell Bioenergetics and Mitochondrial Function,” Digestive and Liver Disease 49, 697-704 (2017).

633. T.T. Reed and D.A. Butterfield, “Protein Carbonylation in Brains of Subjects with Selected Neurodegenerative Disorders,” in Protein Carbonylation: Principles, Analysis, and Biological Implications (J. Ros, Ed.). John Wiley & Sons, Hoboken, NJ, pp. 167-205 (2017).

632. A. Tramutola, C. Lanzillotta, M. Perluigi, and D.A. Butterfield, “Oxidative Stress, Protein Oxidation, and Alzheimer Disease,” Brain Research Bulletin 133, 88-96 (2017).

631. E. Barone, E. Head, D.A. Butterfield, and M. Perluigi, “HNE-modified Proteins in Down Syndrome: Involvement in development of Alzheimer disease neuropathology,” Free Radical Biology and Medicine 111, 262-269 (2017).

630. F. Di Domenico, A. Tramutola, and D.A. Butterfield, “Role of 4-Hydroxy-2-Nonenal (HNE) in the Pathogenesis of Alzheimer Disease and Other Selected Age-Related Neurodegenerative Disorders,” Free Radical Biology and Medicine 111, 253-261 (2017)

629. M. Mitov, J.W. Harris, M.C. Alstott, B.M. Evers, and D.A. Butterfield, “Temperature Induces Significant Changes in both Glycolytic Rerserve and Mitochondrial Spare Respiratory Capacity in Colorectal Cancer Cell Lines,” Experimental Cell Research 354, 112-121 (2017).

628. E.M. Palmieri, A. Menga, A. Lebrun, D.C. Hooper, D.A. Butterfield, M. Mazzone, and A. Castegna, “Blockade of Glutamine Synthetase Strongly Enhances Inflammatory Response in Microglial Cells,” Antioxidants and Redox Signaling 26, 351-363 (2017).

627. F. Di Domenico, E. Barone, M. Perluigi 1 and D.A.Butterfield, “The Triangle of Death in Alzheimer Disease Brain: The Aberrant Cross Talk Among Energy Metabolism, mTOR Signaling and Protein Homeostasis Revealed by Redox Proteomics," Antioxidants and Redox Signaling 26, 364-387 (2017).

626. A. Tramutola, A. Arena, C. Cini, D.A. Butterfield, and Eugenio Barone, “Modulation of GLP-1 Signaling as a Novel Therapeutic Approach in the Treatment of Alzheimer Disease Pathology,” Expert Reviews of Neurotherapeutics 17, 59-75 (2017).

625. A. Tramutola, F. Di Domenico, E. Barone, A. Giorgi, L. di Francesco, M.E. Schinina, R. Coccia, E. Head, D.A. Butterfield*, and M. Perluigi, “Polyubiquityinylation Profile in Down Syndrome Brain Prior to and after Development of Alzheimer Neuropathology,” Antioxidants and Redox Signaling 26, 280-298 (2017). *Co-Corresponding Author.

624. D.A. Butterfield and M. Perluigi, “Redox Proteomics: A Key Tool for New Insights into Protein Modification with Relevance to Disease,” Antioxidants and Redox Signaling 26, 277-279 (2017).

623. X. Ren, D.K. St. Clair, and D.A. Butterfield, “Dysregulation of cytokine mediated chemotherapy induced cognitive impairment,” Pharmacological Research 117, 267-273 (2017).

622. A.M. Swomley, J.C. Triplett, J.T. Keeney, G. Warrier, K.J. Pearson, J.A. Mattison, R. de Cabo, J. Cai, J.B. Klein, and D.A. Butterfield, “Comparative Proteomic Analyses of the Parietal Lobe from Rhesus Monkeys Fed a High Fat/Sugar Diet with and without Resveratrol Supplementation, Relative to a Healthy Diet: Insights into Role of Unhealthy Diets and Resveratrol on Function,” Journal of Nutritional Biochemistry 39, 169-179 (2017).

621. D.A. Butterfield and T.T. Reed, “Lipid Peroxidation and Tyrosine Nitration in Traumatic Brain Injury: Insights into Secondary Injury from Redox Proteomics,” Proteomics-Clinical Applications 10, 1191-1204 (2016).

620. S.A. Farr, M.L. Niehoff, M.A. Ceddia, K.A. Herrlinger, B.J. Lewis, S. Feng, A. Welleford, D.A. Butterfield, and J.E. Morley, “ Effect of Botanical Extracts Containing Carnosic Acid or Rosmarinic Acid on Learning and Memory in SAMP8 Mice,” Physiology & Behavior 165, 328-338 (2016).

619. P. Gupta, C.T. Jordan, M.I. Mitov, D.A. Butterfield, J.Z. Hilt, T.D. Dziubla, “Controlled Circumin Release via Conjugation intp PBAE Nanogels Enhances Mitochondrial Protection Against Oxidative Stress,” International Journal of Pharmaceutics 511, 1012-1021 (2016).

618. A.-L, Lin, D.A. Butterfield, and A. Richardson, “mTOR: Alzheimer’s Disease Prevention for APOE4 Carriers,” Oncotarget 7, 44873 (2016).

617. M. Perluigi, F. Di Domenico, E. Barone, and D. A. Butterfield, “Abberant Protein Phosphorylation in Alzheimer Disease Brain Disturbs Pro-Survival and Cell Death Pathways,” Biochimica et Biophysica Acta-Moleclar Basis of Disease 1862, 1871-1882 (2016).

616. M. Mitov, V.S. Patil, M.C. Alstott, T. Dziubla, and D.A. Butterfield, “In Vitro Cellular Assays for Oxidative Stress and Biomaterial Response,” in Oxidative Stress and Biomaterials, (T. Dziubla and D.A. Butterfield, Eds.), Elsevier Press, Amsterdam, pp. 145-186 (2016).

615. T. Dziubla, and D.A. Butterfield, Oxidative Stress and Biomaterials, Elsevier Press, Amsterdam (2016).

614. W. Zhang, D. St. Clair, D.A. Butterfield, and M. Vore,“Loss of Mrp1 Potentiates Doxorubicin-induced Cytotoxicity in Neonatal Mouse Cardiomyocytes and Cardiac Fibroblasts,” Toxicological Sciences 151, 44-56 (2016).

613. A. Tramutola, G. Pupo, F. Di Domenico, E. Barone, A. Arena, C. Lanzillotta, D. Brokeaart, C. Blarzion, E. Head, D.A. Butterfield, and M. Perluigi, “Activation of p53 in Down Syndrome and in the Ts65Dn Mouse Brain Is Associated with a Pro-apoptotic Phenotype,” Journal of Alzheimers Disease 52, 359-371 (2016).

612. J.C. Triplett, A. Swomley, J. Kirk, K. Grimes, K.atilyn Lewis, M. Orr, K. Rodriguez, J. Cai, J.B. Klein, R. Buffenstein, and D.A. Butterfield,“Reaching Out to Send a Message: Mechanisms Promoting Extended Healthspan in the Long-lived Naked Mole-Rat May Involve Neurite Outgrowth and Neurotransmission,” Neurochemical Research 41, 1625-1634 (2016).

611.D.A. Butterfield, Erika M. Palmieri, and A.Castegna, “Clinical Implications From Proteomic Studies In Neurodegenerative Diseases: Lessons From Mitochondrial Proteins,” Expert Rev Proteomics, 13, 259-274 (2016).

610. F. Di Domenico, G. Pupo, E. Giraldo, A. Lloret, M.C. Badia, M.E. Schinina, A. Giorgi,D. A. Butterfield, J. Vina, M. Perluigi, “Autoantibodies Profile in Matching CSF and Serum from AD and aMCI patients: Potential Pathogenic Role and Link to Oxidative Damage,” Curr Alzheimer’s Res 13, 112-122 (2016).

609. A. Tramutola, F. Di Domenico, E. Barone, M. Perluigi, and D.A. Butterfield, “It’s All About U(biquitin): Role of the Altered Ubiquitin Proteasome System and UCHL1 in Alzheimer Disease,” Oxidative Medicine and Cellular Longevity 2016, (2016).

608. S. Miriyala, C. Thippakorn, L. Chaiswing, Y. Xu, T. Noel, A. Tovmasyan, I. Batinic-Haberle, C. Vander Kooi, W. Chi, A. Abdel Latif, M. Panchatcharam, V. Prachayasittikul, D.A. Butterfield, M. Vore, J. Moscow, and Daret K. St. Clair, “ Novel Role of 4-Hydroxy-2-Nonenal in AIFm2-Mediated Mitochondrial Stress Signaling,” Free Radical Biology & Medicine 91, 68-80 (2016).

607. E. Barone, F. Di Domenico, T. Cassano, A. Arena, A. Tramutola, R. Coccia, D.A. Butterfield*, and M. Perluigi, “Impairment of Biliverdin Reductase-A Promotes Brain Insulin Resistance in Alzheimer Disease: A New Paradigm,” Free Radical Biology & Medicine 91, 127-142 (2016).*Co-Corresponding Author.

606. F. Di Domenico, G. Pupo, E. Giraldo, M.-C. Badia, P. Monllor, A. Lloret, M.E. Schinina, A. Giorgi, A. Tramutola, D.A. Butterfield, J. Vina, and M. Perluigi, “Oxidative Signature of Cerebrospinal Fluid from Mild Cognitive Impairment and Alzheimer Disease Patients,” Free Radical Biology & Medicine 91, 1-9 (2016).

605. F. Di Domenico, M. Perluigi, and ,D.A. Butterfield, "Redox Proteomics in Human Biofluids: Sample Preparation, Separation, and Immunochemical Tagging for Analysis of Protein Oxidation” Methods in Molecular Biology 1303, 391-403 (2016).

604. D.A. Butterfield, “Redox Signaling in Neurodegeneration,” Neurobiology of Disease 84, 1-3 (2015).

603. Jeriel T. Keeney and D.A. Butterfield, “Vitamin D Deficiency and Alzheimer Disease: Common Links,” Neurobiology of Disease 84, 84-98 (2015).

602. M. Perluigi, F. Di Domenico, and D.A. Butterfield, “mTOR Signaling in Aging and Neurodegeneration: At the Crossroads between Metabolism Function and Impairment of Autophagy,” Neurobiology of Disease 84, 39-49 (2015).

601. E. Barone and D.A. Butterfield, “Insulin Resistance in Alzheimer Disease: Is Heme Oxygenase-1 an Achille’s Heel?” Neurobiology of Disease 84, 69-77 (2015).

600. J.C. Triplett, A.M. Swomley, J. Cai, J.B. Klein, and D.A. Butterfield, “Quantitative Phosphoproteomic Analyses of the Inferior Parietal Lobule from Three Different Pathological Stages of Alzheimer’s Disease," Journal of Alzheimer’s Disease 49, 45-62 (2016).

599. A.M. Swomley and D.A. Butterfield, “Oxidative Stress in Alzheimer Disease and Mild Cognitive Impairment: Evidence from Human Data Provided by Redox Proteomics,” Archives of Toxicology 89, 1669-1680 (2015).

598. E. Barone, G. Cenini, F. Di Domenico, T. Noel, C. Wang, M. Perluigi , D.K. St. Clair, and D.A. Butterfield, “Basal Brain Oxidative and Nitrosative Stress Levels Are Finely Regulated by the Interplay between MnSOD and p53,” J. Neurosci. Res. 93, 1728-1739 (2015).

597. F. Di Domenico, M. Perluigi, and D.A. Butterfield, "Redox Proteomics in Human Biofluids: Sample Preparation, Separation, and Immunochemical Tagging for Analysis of Protein Oxidation,” Methods in Molecular Biology 1303, 391-403 (2015).

596. Y. Zaytseva, J.W. Harris, M.I. Mitov, J.T. Kim, D.A. Butterfield, E.Y. Lee, H.L. Weiss, T. Gao, and B.M. Evers, “Increased Expression of Fatty Acid Synthase Provides a Survival Advantage to Colorectal Cancer Cells via Upregulation of Cellular Respiration,” Oncotarget 6, 18891-18904 (2015).

595. J.C. Triplett, A. Tramutola, A. Swomley, J. Jirk, K. Grimes, L. Lewis, M. Orr, K. Rodriguez, J. Cai, J.B. Klein, M. Perluigi, R. Buffenstein and D. A. Butterfield, “Age-related Changes in the Proteostasis Network in the Brain of the Naked Mole-rat: Implications Promoting Healthy Longevity,” Biochimica et Biophysica Acta-Molecular Basis of Disease 1852, 2213-2224 (2015).

594. J.T.R. Keeney, S. Miriyala, T. Noel, J.A. Moscow, D.K. St. Clair, and D.A. Butterfield, "Superoxide Induces Protein Oxidation in Plasma and TNF-α Elevation in Macrophage Culture:  Insights into Mechanisms of Neurotoxicity Following Doxorubicin Chemotherapy,” Cancer Letters 367, 157-161 (2015).

593. J. C. Triplett, A. Swomley, J. Kirk, K. Lewis, M. Orr, K. Rodriguez, J. Cai, J.B. Klein, R. Buffenstein, and D.A. Butterfield, “Metabolic Clues to Salubrious Longevity in the Brain of the Longest-lived Rodent: the Naked Mole-Rat,” Journal of Neurochemistry 134, 538-550 (2015).

592. C.–H. Chen, W. Li, R. Sultana, M.-H. You, A. Kondo, K. Shahpasand, B.M. Kim, M. Luo, M. Nechama, Y.-M. Lin, Y. Yao, T.H. Lee, X.Z. Zhou, A.M. Swomley, D.A. Butterfield, Y. Zhang, and K.P. Lu, “Pin 1 Cysteine-113 Oxidative Inhibits Its Catalytic Activity and Cellular Function in Alzheimer’s Disease,” Neurobiology of Disease," Neurobiology of Disease 76, 13-23 (2015).

591. J. Hayslip, E.V. Dressler, H. Weiss, T.J. Taylor, M. Chambers T. Noel, S. Miriyala, J.T.R. Keeney, X. Ren, R. Sultana, M. Vore, D.A. Butterfield, D. St. Clair, and J.A. Moscow, “Plasma TNF-a and Soluble TNF Receptor Levels after Doxorubicin with or without Co-administration of Mesna—A Randomized Cross-over Clinical Study,” PLoS One 10, e124988 (2015).

590. J. Triplett, Z. Zhang, R. Sultana, J. Cai, J. Klein, H. Büeler, and D.A. Butterfield, "Quantitative Expression Proteomics and Phosphoproteomics Profiles of Brain from PINK1 Knockout Mice: Insights into Mechanisms of Familial Parkinson Disease," J Neurochem 133, 750-765 (2015).

589. A. Tramutola, J. Triplett, F. Di Domenico, D.M. Niedowicz, M.P. Murphy, R. Coccia, M. Perluigi, and D.A. Butterfield, “Alteration of mTOR Signaling Occurs Early in the Progression of Alzheimer Disease: Analysis of Brain from Subjects with Preclinical AD, Amnestic Mild Cognitive Impairment and Late-Stage AD,” J Neurochem 133, 739-749 (2015).

588. F. Di Domenico, G. Pupo, C. Mancuso, E. Barone, F. Paolini, A. Arena, C. Blarzino, F.A. Schmitt, E. Head, D.A. Butterfield, and M. Perluigi, “Bach1 Overexpression in Down Syndrome Correlates with the Alteration of the HO-1/BVR-A System: Insights for Transition to Alzheimer Disease,” Journal of Alzheimer’s Disease 44, 1107-1120 (2015).

587. F. Di Domenico, E. Barone, M. Perluigi, and D.A. Butterfield, “Strategy to Reduce Free Radical Species in Alzheimer’s Disease: An Update of Selected Antioxidants,” Expert Review of Neurotherapeutics 22, 1-22 (2014).

586. T.T. Reed, Z.P. Sellers, and D.A. Butterfield, "Lipid Peroxidation in Age-related Neurodegenerative Disorders," in Lipid Oxidation in Health and Disease," C.M. Spickett and H.J. Forman, Eds., Taylor and Francis Publishers, Boca Raton, FL., pp. 329-361 (2015).

585. M. Perluigi and D.A. Butterfield, “Down Syndrome as a Special Case of Oxidatively Induced Developmental Dysregulation,” in Perinatal and Prenatal Disorders, P.A. Dennery, G. Buonocore, and O.D. Saugstad, Eds., Springer, New York, pps. 127-142 (2014).

584. G. Cenini, A. Fiorini, R. Sultana, M. Perluigi, J. Cai, J.B. Klein, E. Head, and D.A. Butterfield, “An Investigation of the Molecular Mechanisms Engaged Before and After the Development of Alzheimer Disease Neuropathology in Down Syndrome:  A Proteomics Approach,” Free Radical Biology & Medicine 76, 89-95 (2014).

583. D.A. Butterfield, F. Di Domenico, A.M. Swomley, E. Head, and M. Perluigi, “Redox Proteomics Analysis to Decipher the Neurobiology of Alzheimer-like Neurodegeneration: Overlaps in Down Syndrome and Alzheimer Disease Brain,” Biochemical Journal 463, 177-189 (2014).

582. S.S. Hardas, R. Sultana,W. Govind, M. Dan, P. Wu, E. Grulke, M. Tseng, J. Unrine, U. Graham, R. Yokel, and D.A. Butterfield, “Rat Hippocampal Responses Up to 90 Days after a Single Nanoceria Dose Extends a Hierarchical Oxidative Stress Model for Nanoparticle Toxicity,” Nanotoxicology 81, 155-166 (2014).

581. M.T. Tseng, Q. Fu, K. Lor, R. Fernandez-Botron, Z.B. Deng, U.M. Graham, D.A. Butterfield, E. Grulke, and R.A. Yokel, "Persistent Hepatic Structural Alterations Following Nanoceria Vascular Infusion in the Rat," Toxicologic Pathology 42, 984-996 (2014).

580. U.M. Graham, M.T. Tseng, J.B. Jasinski, R.A. Yokel, J.M. Unrine, B.H. Davis, A.K. Dozier, S.S. Hardas, R. Sultana, E.A. Grulke, and D.A. Butterfield, “In Vivo Processing of Ceria Nanoparticles Inside Liver: Impact on Free Radical Scavenging Activity and Oxidative Stress,” ChemPlusChem 79, 1083-1089 (2014).

579. D.A. Butterfield, “THE 2013 SFRBM DISCOVERY AWARD: Selected Discoveries from the Butterfield Laboratory of Oxidative Stress and Its Sequela in Brain in Cognitive Disorders Exemplified by Alzheimer Disease and Chemotherapy Induced Cognitive Impairment,” Free Radical Biology & Medicine 74, 157-174 (2014).

578. D. A. Butterfield, Fabio Di Domenico, and Eugenio Barone, "Elevated Risk of Type 2 Diabetes for Development of Alzheimer Disease: a Key Role for Oxidative Stress in Brain," Biochimica et Biophysica Acta - Molecular Basis of Disease 1842, 1693-1706 (2014).

577. F. Di Domenico, E. Head, D.A. Butterfield, and M. Perluigi, "Oxidative Stress and Proteostasis Network: Culprit and Casualty of Alzheimer’s-Like Neurodegeneration," Advances in Geriatrics 2014, 1-14 (2014).

576. S. Förster, A.S. Welleford, J.C. Triplett, R. Sultana, B. Schmitz, and  D.A. Butterfield, “Increased O-GlcNAc Levels Correlate with Decreased O-GlcNAcase Levels in Alzheimer Disease Brain,”  Biochimica et Biophysica Acta - Molecular Basis of Disease 1842, 1333-1339 (2014).

575. A.M. Swomley, S. Forster, J. Keeney, J. Triplett, Z. Zhang, R. Sultana, and D.A. Butterfield, “Abeta, Oxidative Stress in Alzheimer Disease: Evidence Based on Proteomics Studies,” Biochimica et Biophysica Acta 1842, 1248-1257 (2014).

574. D.A. Butterfield, F. Di Domenico, and R.A.S. Robinson, “Mass Spectrometry and Redox Proteomics: Applications in Disease,” Mass Spectrometry Reviews 33, 277-301 (2014).

573. M. Perluigi, G. Pupo, A. Tramutola, C. Cini, R. Coccia, E. Barone, E. Head, D.A. Butterfield, and F. Di Domenico, Neuropathological Role of PI3K/AKT/mTOR Axis in Down Syndrome Brain,” Biochim. Biophys. Acta-Molec. Basis Dis. 1842, 1144-1153  (2014).

572. F. Di Domenico, G. Pupo, A. Tramutola, A. Giorgi, M. Eugenia Schininà, R. Coccia, E. Head, D.A. Butterfield, and M. Perluigi, “Redox Proteomics Analysis of HNE-Modified Proteins in DS Brain: Clues for Understanding Development of Alzheimer Disease,”  Free Radical Biology & Medicine 71, 270-280 (2014).

571. Y. Zhao, S. Miriyala, L. Miao, M. Mitov, D. Schnell, S. Dhar, J. Cai, J.B. Klein, R. Sultana, D.A. Butterfield, M. Vore, S. Bondada, and D.K. St. Clair, ”Redox Proteomic Identification of HNE-bound Mitochondrial Proteins in Cardiac Tissues Reveals a Systemic Effect on Energy Metabolism after Doxorubicin Treatment,” Free Radical Biology & Medicine 72, 55-65 (2014).

570. E. Barone, F. Di Domenico, and D.A. Butterfield, “Statins More Than Cholesterol Lowering Agents in Alzheimer Disease: Their Pleiotropic Functions as Potential Therapeutic Targets” Biochemical Pharmacology 88, 605-616 (2014).

569. M. Perluigi, F. Di Domenico, and D.A. Butterfield “Unraveling the Complexity of Neurodegeneration in Brains of Subjects with Down Syndrome: Insights from Proteomics,” Proteomics Clinical Applications 8, 73-85 (2014).

568. L. Ulatowski, R. Parker, G. Warrier, R. Sultana, D.A. Butterfield, and D. Manor, "Vitamin E is Essential for Purkinje Neuron Integrity," Neuroscience 260, 120-129 (2014).

567. M. Perluigi, A.M. Swomley, and D.A. Butterfield, “Redox Proteomics and the Dynamic Molecular Landscape of the Aging Brain,” Ageing Research Reviews 13, 75-89 (2014).

566. S.A. Farr, J.L. Ripley, R. Sultana, Z. Zhang, M.L. Niehoff, T.L. Platt, M.P. Murphy, J.E. Morley, V. Kumar, and D.A. Butterfield, “Antisense Oligonucleotide Against GSK-3b in Brain of SAMP8 Mice Improves Learning and Memory and Decreases Oxidative Stress: Involvement of Transcription Factor Nrf2 and Implications for Alzheimer Disease,” Free Radical Biology and Medicine 67, 387-395 (2014).

565. D.A. Butterfield and I. Dalle-Donne, "Redox Proteomics: From Protein Modification to Cellular Dysfunction and Disease," Mass Spectrometry Reviews 33, 1-6 (2014).

564. E. Barone, F. Di Domenico, C. Mancuso, and D.A. Butterfield, “The Janus Face of the Heme Oxygenase/Biliverdin Reductase System in Alzheimer Disease: It's Time for Reconciliation,” Neurobiology of Disease 62,144-159 (2014).

563. R. Sultana and D.A. Butterfield, "Oxidative Modification of Brain Proteins in Alzheimer Disease: Prespective on Future Studies Based on Results of Redox Proteomics Studies," Journal of Alzheimer's Disease 33, S243-S251 (2013).

562. V. Makani, R. Sultana, K. Sie, D. Orjiako, M. Tat, A. Dowling, J. Cai, WM Pierce, D.A. Butterfield, J.W. Hill, and J. Park, "Annexin A1 Complex Mediates Oxytocin Vesicle Transport" Journal of Neuroendocrinology 25, 1241-1254 (2013).

561. R. Sultana, A.M. Swomley, and D.A. Butterfield, “Brain Oxidative Stress in the Pathogenesis and Progression of Alzheimer Disease,” in Studies on Alzheimer’s Disease, D. Pratico and P. Mecocci, Eds., Humana Press/Springer, New York,  pp. 99-118 (2013).

560. R. Sultana, G. Cenini, and D.A. Butterfield, “Biomarkers of Oxidative Stress in Neurodegenerative Diseases,” in Molecular Basis of Oxidative Stress: Chemistry, Mechanisms, and Disease Pathogenesis, F.A. Villamena, Editor, John Wiley & Sons, Inc., Hoboken, New Jersey, pps. 359-376 (2013).

559. R. Sultana, M. Baglioni, R. Cecchetti, J. Cai, J.B. Klein, P. Bastiani, C. Ruggiero, P. Mecocci, and D.A. Butterfield, “Lymphocyte Mitochondria: Toward Identification of Peripheral Biomarkers in Progression of Alzheimer Disease,” Free Radical Biology & Medicine 65, 595-606 (2013).

558. D.A. Butterfield, A. Swomley, and R. Sultana, "Amyloid β-Peptide 1-42-induced Oxidative Stress in Alzheimer Disease: Importance in Disease Pathogenesis and Progression," Antioxidant Redox Signal 19, 823-835 (2013).

557. J.T. Keeney, S. Forster, R. Sultana, L.D. Brewer, C.S. Latimer, J. Cai, J.B. Klein, N.M Porter, and D.A. Butterfield, "Dietary Vitamin D Deficiency in Rats from Middle- to Old-age Leads to Elevated Tyrosine Nitration and Proteomics Changes in Levels of Key Proteins in Brain: Implications for Low Vitamin D-dependent Age-Related Cognitive Decline," Free Radical Biology and Medicine 65, 324-334 (2013).

556. R. Sultana, M. Perluigi, and D.A. Butterfield, “Lipid Peroxidation Triggers Neurodegeneration: A Redox Proteomics View into the Alzheimer Disease Brain,” Free Radic. Biol. Med. 62, 157-169 (2013).

555. A. Fiorini, R. Sultana, S. Forster, M. Perluigi, G. Cenini, C. Cini, J. Cai, J.B. Klein, S.A. Farr, M.L. Niehoff, J.E. Morley, V.B. Kumar, and D.A. Butterfield, “Antisense Directed Against PS-1 Gene Decreases Brain Oxidative Markers in Aged Senescence Accelerated Mice (SAMP8) and Reverses Learning and Memory Impairment: A Proteomics Study,” Free Radical Biology and Medicine 65, 1-14 (2013).

554. F. Di Domenico, R. Coccia, A. Cocciolo, M.P. Murphy, G. Cenini, E. Head, D.A. Butterfield, A. Giorgi, M.E. Schininà, C. Mancuso, C. Cini, and M. Perluigi,  “Impairment of Protestasis Network in Down Syndrome Prior to the Development of Alzheimer’s Disease Neuropathology: Redox Proteomics Analysis of Human Brain,” Biochim. Biophys. Acta—Molec. Basis Dis. 1832, 1249-1259 (2013).

553. R.A.S. Robinson and D.A. Butterfield, "Insights from Proteomics into Mild Cognitive Impairment, Likely the Earliest Stage of Alzheimer's Disease, in Alzheimer's Disease Research Compendium, M.-K. Sun, Ed., Nova Science Publishers, Columbus, OH, pp. 97-116 (2013).

552. S.S. Hardas, R. Sultana, A.M. Clark, C. Bracket, L.I. Szweda,  M.P. Murphy, and D. A. Butterfield,  “Oxidative Modification of Lipoic Acid by HNE in Alzheimer Disease Brain,” Redox Biology 1, 80-85 (2013).

551. J.T. Keeney, A.M. Swomley, S. Förster, J.L. Harris, R. Sultana, and D.A. Butterfield, “Apolipoprotein A-I: Insights From Redox Proteomics for Its Role in Neurodegeneration,” Proteomics—Clinical Applications 7, 109-122 (2013).

550. P. Jungsuwadee, T. Zhao, E.I. Stolarczyk, C.M. Paumi, D.A. Butterfield, D.K. St..Clair, and M. Vore, “The G671V Variant of MRP1/ABCC1 Links Doxorubicin-Induced Acute Cardiac Toxicity to Disposition of the Glutathione Conjugate of 4-Hydroxy-2-Trans-Nonenal,” Pharmacogenetics and Genomics Journal 22, 273-284 (2012).

549. F. Di Domenico, M. Perluigi, and D.A. Butterfield, “Redox Proteomics Studies on C.elegans Models: A Simple Organism that Provides Insights into Complex Neurodegenerative Disorders,” European Journal of Neurodegenerative Disorders 1, 279-291 (2012).

548. A. Fiorini, R. Sultana, E. Barone, G. Cenini, M. Perluigi, C. Mancuso, J. Cai, J.B. Klein, D. St. Clair, and D.A. Butterfield, “Lack of p53 Affects the Expression of Several Brain Mitochondrial Proteins: Insights From Proteomics into Important Pathways Regulated by p53,” PLoS One 2012;7, e49846 (2012).

547. C. Pocernich, D.A. Butterfield, and L. Head, “Diet and Brain Aging: Effects on Cell and Mitochondrial Function and Structure,” in Bioactive Food as Dietary Interventions for the Aging Population, (R.R. Watson and V.R. Preedy, Eds.), Elsevier Publishers, Amsterdam, 249-262 (2012).

546. R. Sultana, G. Cenini, and D.A. Butterfield, “SAMP8: A Model to Understand the Role of Oxidative Stress in Age-Related Diseases Including Alzheimer’s Disease,” in  The Senescence Accelerated Mouse (SAM): Achievements and Future Directions, (T. Takeda, Ed.), Elsevier Publishers, Amsterdam, 361-370 (2012).

545. R. Khanna, S.M. Wilson, J.M. Brittain, J. Weimer, R. Sultana, A. Butterfield, and K. Hensley, “Opening Pandora’s Jar: A Primer on the Putative Roles of CRMP2 in a Panoply of Neurodegenerative, Sensory and Motor Neuron, and Central Disorders,” Future Neurology 7, 749-771 (2012).

544. F. Di Domenico, E. Barone, C. Mancuso, M. Perluigi, A. Cocciolo, P. Mecocci, D.A. Butterfield, and R. Coccia, “HO-1/BVR-A System Analysis in Plasma from Probable Alzheimer's Disease and Mild Cognitive Impairment Subjects: A Potential Biochemical Marker for the Prediction of the Disease,” Journal of Alzheimer's Disease 32, 277-289 (2012).

543. S.S. Hardas, R. Sultana, G. Warrier, M. Dan, R.L. Florence, P. Wu, E.A. Grulke, M.T. Tseng, J.M. Unrine, U.M. Graham, R.A. Yokel, and D.A. Butterfield, “Rat Brain Pro-Oxidant Effects of Peripherally Administered 5 nm Ceria 30 Days After Exposure,” Neurotoxicology 33, 1147-1155 (2012).

542. A. Cocciolo, F. Di Domenico1, R. Coccia, A. Fiorini, J. Cai, W.M. Pierce, P. Mecocci, D.A. Butterfield, and M. Perluigi, “Decreased expression and increased oxidation of plasma haptoglobin in Alzheimer disease: Insights From redox proteomics,” Free Radic. Biol. Med. 53, 1868-1876 (2012).

541. D.A. Butterfield, M. Perluigi, T. Reed, T. Muharib, C. Hughes, R. Robinson, and R. Sultana, “Redox Proteomics in Selected Neurodegenerative Disorders. From its Infancy to Future Applications,” Antioxidants and Redox Signaling 17, 1610-1655 (2012).

540. M. Perluigi, R. Coccia, and D.A. Butterfield, “4-Hydroxy-2-Nonenal, a Reactive Product of Lipid Peroxidation, and Neurodegenerative Diseases: A Toxic Combination Illuminated by Redox Proteomics Studies,” Antioxidants and Redox Signaling 17, 1590-1609 (2012).

539. R. Sultana, R.A.S. Robinson, M. Bader Lange, A. Fiorini, V. Galvan, J. Fombonne, A. Baker, O. Gorostiza, J. Zhang, J. Cai, W. Pierce, D. Bredesen, and D.A. Butterfield, “Do Proteomics Analyses Provide Insights into Reduced Oxidative Stress in Brain of an Alzheimer Disease Transgenic Mouse Model with an M631L Amyloid Precursor Protein Substitution and Thereby the Importance of Amyloid-Beta-Resident Methionine 35 in Alzheimer Disease Pathogenesis?” Antioxidants and Redox Signaling 17, 1507-1514 (2012).

538. F. Di Domeico, R. Sultana, A. Ferree, K. Smith, E. Barone, M. Perluigi, R. Coccia, W. Pierce, J. Cai, C. Mancuso, R. Squillace, M. Weingele, I. Dalle-Donne, B. Wolozin, and D.A. Butterfield, "Redox Proteomics Analyses of the Influence of Co-Expression of Wild Type or Mutated LRRK2 and Tau on C. elegans Protein Expression and Oxidative Modification: Relevance to Parkinson Disease," Antioxidants and Redox Signaling 17, 1490-1506 (2012).

537. D.A. Butterfield and I. Dalle-Donne, "Redox Proteomics," Antioxidants and Redox Signaling 17, 1487-1489 (2012).

536. O.V. Tsyusko, S.S. Hardas, W.A. Shoults-Wilson, C.P. Starnes, G. Joice, D.A. Butterfield, and J.M. Unrine, “Short-Term Molecular-Level Effects of Silver Nanoparticle Exposure on the Earthworm, Eisenia Fetida,” Environmental Pollution 171, 249-255 (2012).

535. J.T. Keeney, A.M. Swomley, J.L. Harris, A. Fiorini, M.I. Mitov, M. Perluigi, R. Sultana, and D.A. Butterfield, “Cell Cycle Proteins in Brain in Mild Cognitive Impairment: Insights into Progression to Alzheimer’s Disease,” Neurotox. Res. 22, 220-230 (2012).

534. D.A. Butterfield, E. Barone, F. Di Domenico, G. Cenini, R. Sultana, M.P. Murphy, C. Mancuso, and E. Head, "Atorvastatin Treatment in a Dog Preclinical Model of Alzheimer Disease Leads to Up-regulation of Heme Oxygenase-1 and Is Associated with Reduced Oxidative Stress in Brain," Internat. J. Neuropsychopharmacol. 15, 981-987 (2012).

533. M.A. Erickson, P.E. Hartvigson, Y. Morofuji, J.B. Owen, D.A. Butterfield, and W.A. Banks. “Lipopolysaccharide Impairs Amyloid Beta Efflux From Brain: Altered Vascular Sequestration, Cerebrospinal Fluid Reabsorption, Peripheral Clearance and Transporter Function at the Blood-Brain Barrier,” J. Neuroinflammation 9, 150 (2012).

532. E. Barone, F. Di Domenico, R. Sultana, R. Coccia, C. Mancuso, M. Perluigi, and D.A. Butterfield, “Heme Oxygenase-1 Posttranslational Modifications in the Brain of Subjects with Alzheimer Disease and Mild Cognitive Impairment,” Free Radical Biology and Medicine 52, 2292–2301 (2012).

531. A.R. Evans, S. Miriyala, D.K. St. Clair, D.A. Butterfield, and R.A. Robinson, “Global Effects of Adriamycin Treatment on Mouse Splenic Protein Levels,” J. Proteome Res. 11, 1054-1064 (2012).

530. P. Jungsuwadee, T. Zhao, E.I. Stolarczyk, C.M. Paumi, D.A. Butterfield, D.K. St.Clair, and M. Vore, “The G671V Variant of MRP1/ABCC1 Links Doxorubicin-Induced Acute Cardiac Toxicity to Disposition of the Glutathione Conjugate of 4-Hydroxy-2-Trans-Nonenal,” Pharmacogenetics and Genomics Journal 22, 273-284 (2012).

529. E. Barone, G. Cenini, R. Sultana, F. Di Domenico, A. Fiorini, T. Noel, C. Mancuso, D.K. St. Clair, and D.A. Butterfield, “Lack of p53 Decreases Basal Oxidative Stress Levels in Brain Through Up-Regulation of Thioredoxin-1, Biliverdin Rederctase-A, Manganese Superoxide Dismutase, and Nuelear Factor-kapa B,” Antioxidants and Redox Signaling 16, 1407-1420 (2012).

528. R. Siciliano, E. Barone, V. Calabrese, V. Rispoli, D.A. Butterfield, and C. Mancuso, "Experimental Research On Nitric Oxide and the Therapy of Alzheimer Disease: A Challenging Bridge,” CNS Neurol Disord Drug Targets 10, 766-776 (2012).

527. F. De Marco, E. Bucaj, C. Foppoli, A. Fiorini, C. Blarzino, K. Filipi, A. Giorgi, M.E. Schininà, F. Di Domenico, R. Coccia, D.A. Butterfield, and M. Perluigi, “Oxidative Stress in HPV-Driven Viral Carcinogenesis: Redox Proteomics analysis of HPV-16 Dysplastic and Neoplastic Tissues,” Plos One 7, e34366 (2012).

526. M.T. Tseng, X. Lu, X. Duan, S.S. Hardas, R. Sultana, P. Wu, J.M. Unrine, U. Graham, D.A. Butterfield, E.A. Grulke, and R.A. Yokel, "Alteration of Hepatic Structure and Oxidative Stress Induced by Intravenous Nanoceria," Toxicology and Applied Pharmacology 260, 173-182 (2012).

525. R.A. Yokel, T.C. Au, R. MacPhail, S.S. Hardas, D.A. Butterfield, R. Sultana, M. Goodman, M.T. Tseng, M. Dan, A. Hughnazar, J.M. Unrine, U.M. Gram, P. Wn, and E.A. Grulhe, “Distribution, Elimination and Biopersistence to 90 Days of a Systemically-Introduced 30nm Ceria Engineered Nanomaterial in Rats,” Toxicological Sciences 127, 256-268 (2012).

524. F. Di Domenico, G. Casalena, J. Jia, R. Sultana, E. Barone, J. Cai, W.M. Pierce, C. Cini, M. Perluigi, C.M. Davis, N.J. Alkayed, and D.A. Butterfield, "Sex Differences in Brain Proteomes of Nuron-Specific Stat3-Null Mice after Cerebral Ischemia/Reperfusion," Journal of Neurochemistry 121, 680-692(2012).

523. G. Colombo, I. Dalle-Donne, M. Orioli, D. Giustarini, R. Rossi, M. Clerici; Luca  Regazzoni, G. Aldini, A. Milzani, D.A. Butterfield, and N. Gagliano, “Oxidative Damage in Human Gingival Fibroblasts Exposed to Cigarette Smoke,” Free Radical Biology & Medicine 52, 1584-1596 (2012).

522. D.A. Butterfield and J.N. Keller, “Antioxidants and Antioxidant Treatment in Disease,” Biochim. Biophys. Acta – Molecular Basis of Disease 1822, 615 (2012).

521. C.B. Pocernich and D.A. Butterfield, "Elevation of Glutathione as a Therapeutic Strategy in Alzheimer Disease,” Biochim. Biophys. Acta – Molecular Basis of Disease 1822, 625-630 (2012).

520. L. Buizza, G. Cenini, C. Lanni, G. Ferrari-Toninelli, C. Prandelli, S. Govoni, E. Buoso, M. Racchi, M. Barcikowska, M. Styczynska, A. Szybinska, D.A. Butterfield, M. Memo, and D. Uberti, “Conformational Altered p53 as an Early Marker of Oxidative Stress in Alzheimer's Disease,” PLoS One  2012;7, e29789 (2012).

519. E. Barone, C. Mancuso, F. Di Domenico, R. Sultana, M.P. Murphy, E. Head, and D.A. Butterfield, “Biliverdin Reductase-A: a Novel Drug Target for Atorvastatin in a Dog Preclinical Model of Alzheimer Disease,” Journal of Neurochemistry 120, 135-146(2012).

518. M. Perluigi and D.A. Butterfield, "Oxidative Stress and Down Syndrome: a Route Toward Alzheimer-like Dementia," Current Gerontology and Geriatrics Research 2012:724904 (2012).

517. G. Cenini, A. Dowling, T. Beckett, E. Barone, C. Mancuso, M.P. Murphy, H. Levine, I. Lott, F. Schmitt, D.A. Butterfield, and E. Head, “Association Between Frontal Cortex Oxidative Damage and Beta-Amyloid as a Function of Age in Down Syndrome,” Biochim Biophys. Acta-Molec. Basis of Disease 1822, 130-138 (2012).

516. F. Di Domenico, R. Coccia, D.A. Butterfield, and M. Perluigi, “Circulating Biomarkers of Protein Oxidation for Alzheimer Disease: Expectations within Limits,” Biochim. Biophys. Acta- Proteins and Proteomics 1814, 1785-1795 (2011).

515. R.A.S. Robinson, G. Joshi, Q. Huang, R. Sultana, A.S. Baker, J. Cai, W.M. Pierce, D.K. St. Clair, W.R. Markesbery, and D.A. Butterfield, “Proteomics Analysis of Brain Proteins in APP/PS-1 Human Double Mutant Knock-in Mice with Increasing Amyloid β-Peptide Deposition:  Insights into the Effects of in vivo Treatment with N-Acetylcysteine as a Potential Therapeutic Intervention in Mild Cognitive Impairment and Alzheimer Disease,”Proteomics 11, 4243-4256 (2011).

514. R.A.S. Robinson,  M. Bader Lange, R.Sultana, V. Galvan, J. Fombonne, O. Gorostiza, J. Zhang, G. Warrier, J. Cai, W.M. Pierce,D.E. Bredesen, and D.A. Butterfield, “Differential Expression and Redox Proteomics Analyses of an Alzheimer Disease Transgenic Mouse Model:  Effects of the Amyloid-β Peptide of Amyloid Precursor protein(=),” Neuroscience 177, 207-222 (2011).

513. R. Sultana, R.A.S. Robinson, H. Mohmmad Abdul, F. Di Domenico, D.K. St. Clair, W.R. Markesbery, J. Cai, W.M. Pierce, and D.A. Butterfield, "Proteomics Identification of Specifcally Carbonylated Brain Proteins in APPNLh/APPNLh X PS-1P264L/PS-1P264L Human Double Mutant Knock-in Mice Model of Alzheimer Disease as a Function of Age,” J. Proteomics 74, 2430-2440 (2011).

512. P.P. Wattamwar, S.S. Hardas, D.A. Butterfield, K.W. Anderson, and T.D. Dziubla, “Tuning of the Pro-Oxidant and Antioxidant Activity of Trolox Through the Controlled Release From Biodegradable Poly(Trolox Ester) Polymers,” Journal of Biomedical Materials Research, Part A 99, 184-191 (2011).

511. S.B. Martin, G. Cenini, E. Barone, A.L. Dowling, C. Mancuso, D.A. Butterfield, M.P. Murphy, and E. Head, "Coenzyme Q10 and Cognition in Atorvastin-treated Dogs," Neuroscience Letters 501, 92-95 (2011).

510. C. Mancuso, R. Siciliano, E. Barone, D.A. Butterfield, and P. Preziosi, “Pharmacologists and Alzheimer Disease Therapy: To Boldly Go Where No Scientist Has Gone Before,” Expert Opinion in Investigational Drugs 20, 1243-1261 (2011).

509. E. Barone, F. Di Domenico, G. Cenini, R. Sultana, R. Coccia, P. Preziosi, M. Perluigi, C. Mancuso, and D.A. Butterfield, “Oxidative and Nitrosative Modifications of Biliverdin Reductase in the Brain of Subjects with Alzheimer Disease and Mild Cognitive Impairment,”Journal of Alzheimer’s Disease 25, 623-633 (2011).

508. M. Perluigi and D.A. Butterfield, “The Identification of Protein Biomarkers for Oxidative Stress in Down Syndrome,” Expert Reviews of Proteomics 8, 427-429 (2011).

507. D.A. Butterfield, E. Barone, and C. Mancuso, “Cholesterol-Independent Neuroprotective and Neurotoxic Activities of Statins: Perspectives for Statin Use in Alzheimer Disease and Other Age-Related Neurodegenerative Disorders,” Pharmacological Research 64, 180-186 (2011).

506. D.A. Butterfield and R.Sultana, “Methionine-35 of Aβ (1–42): Importance for Oxidative Stress in Alzheimer Disease," Journal of Amino Acids 2011, 1-10 (2011).

505. F. Di Domenico, R. Sultana, E. Barone, M. Perluigi, C. Cini, C. Mancuso,J. Cai, W.M. Pierce, and D.A. Butterfield, “Quantitative Proteomics Analysis of Phosphorylated Proteins in the Hippocampus of Alzheimer's Disease Subjects,” Journal of Proteomics 74, 1091-1103 (2011).

504. C.B. Pocernich, M.L. Bader Lange, R. Sultana, and D.A. Butterfield, "Nutritional Approaches to Modulate Oxidative Stress in Alzheimer’s Disease," Current Alzheimer's Research 8, 452-469 (2011).

503. C.D. Aluise, S. Miriyala, T. Noel, R. Sultana, P. Jungsuwadee, T.J.Taylor, J. Cai, W.M. Pierce, M. Vore, J.A. Moscow, D.K. St. Clair, and D.A. Butterfield, “2-Mercaptoethanesulfonate (MESNA) Prevents Doxorubicin-Induced Plasma Protein Oxidation and TNFa Release,” Free Radical Biology & Medicine 50, 1630-1638 (2011).

502. M. Perluigi, F. Di Domenico, A. Fiorini, A. Cocciolo, A. Giorgi, C. Foppoli, D.A. Butterfield, M. Giorlandino, C. Giorlandino, M.E. Schinina, and R. Coccia, “Oxidative Stress Occurs Early in Down Syndrome Pregnancy: A Redox Proteomics Analysis of Amniotic Fluid,” Proteomics—Clinical Applications 167-178 (2011).

501. R. Sultana, P. Mecocci, F. Mangialasche, R. Cecchetti, and D.A. Butterfield, “Increased Protein and Lipid Oxidative Damage in Mitochondria Isolated From Lymphocytes From Patients with Alzheimer Disease: Insights into the Role of Oxidative Stress in Alzheimer's Disease and Initial Investigations into a Potential Biomarker for this Dementing Disorder,” Journal of Alzheimer's Disease 24, 77-84 (2011).

500. R. Sultana and D.A. Butterfield, “Brain Protein Oxidation and Modification for Good or for Bad in Alzheimer’s Disease,” Advances in Neurobiology 1, 585-605 (2011).

499. D.A. Butterfield, "Oxidative Stress in Alzheimer Disease: Synergy Between the Butterfield and Markesbery Laboratories," NeuroMolecular Medicine 13, 19-22 (2010.

498. D.A. Butterfield "Preface to the Special Issue of NeuroMolecular Medicine in Memory of the Life and Legacy of William R. Markesbery, M.D.," NeuroMolecular Medicine 13, 1-2 (2011).

497. D.A. Butterfield, T.T. Reed, and R. Sultana,"Roles of 3-Nitrotyrosine- and 4-Hydroxynonenal-Modified Brain Proteins in the Progression and Pathogenesis of Alzheimer's Disease," Free Radical Research 45, 59-72 (2011).

496. R. Sultana and D.A. Butterfield, “Identification of the Oxidative Stress Proteome in the Brain,” Free Radical Biology Medicine 50, 487-494 (2011).

495. D.A. Butterfield, “Atorvastatin and Aβ(1-40): Not as Simple as Cholesterol Reduction in Brain and Relevance to Alzheimer Disease,” Experimental Neurology 228, 15-18 (2011).

494. E. Barone, F. Di Domenico, G. Cenini, R. Sultana, C. Cini, P. Preziosi, M. Perluigi, C. Mancuso, and D.A. Butterfield, “Biliverdin Reductase-A Protein Levels and Activity in the Brains of Subjects with Alzheimer's Disease and Mild Cognitive Impairment,” Biochimica Biophysica Acta-Molecular Basis of Disease 1812, 480-487 (2011).

493. E. Barone, G. Cenini, F. Di Domenico, S. Martin, R. Sultana, C. Mancuso, M. Paul Murphy, E. Head, and D. Allan Butterfield, "Long-term High-dose Atorvastatin Decreases Brain Oxidative and Nitrosative Stress in a Preclinical Model of Alzheimer Disease: a Novel Mechanism of Action," Pharmacological Research 63, 172-180 (2011).

492. D.A. Butterfield and J.B. Owen, “Lectin-Affinity Chromatography Brain Glycoproteomics and Alzheimer Disease: Insights into Protein Alterations Consistent with the Pathology and Progression of this Dementing Disorder,” Proteomics—Clinical Applications 5, 50-56 (2011).

491. C.D. Aluise, R.A.S. Robinson, J. Cai, W.M. Pierce, W.R. Markesbery, and D.A. Butterfield, “Redox Proteomics Analysis of Brains From Subjects with Amnestic Mild Cognitive Impairment Compared to Brains From Subjects with Preclinical Alzheimer's Disease: Insights into Memory Loss in MCI,” Journal of Alzheimer’s Disease 23, 257-269 (2011).

490. F. Di Domenico, M. Perluigi, D.A. Butterfield, C. Cornelius, and V. Calabrese, “Oxidative Damage in Rat Brain During Aging: Interplay Between Energy and Metabolic Key Target Proteins,” Neurochem Res. 35, 2184-2192 (2010).

489. R.A. Sowell and D.A. Butterfield, “Spontaneous Vertebrate Models of Alzheimer Dementia: Selectively bred strains (SAM strains),” in Animal Models of Dementia, Neuromethods Series, Humana Press Inc.; New York, 271-293 (2010).

488. R. Sultana, F. Di Domenico, M. Tseng, J. Cai, T. Noel, R.L. Chelvarajan, W.D. Pierce, C. Cini, S. Bondada, D.K. St. Clair, and D.A. Butterfield, “Doxorubicin-Induced Thymus Senescence,” Journal of Proteome Research 9, 6232-6241(2010).

487. M. Perluigi, F. Di Domenico, A. Giorgi, M.E. Schininà, R. Coccia, C. Cini, F. Bellia, M.T. Cambria, C. Cornelius, D.A. Butterfield, and V. Calabrese, “Redox Proteomics in Aging Rat Brain: Involvement of Mitochondrial Reduced Glutathione Status and Mitochondrial Protein Oxidation in the Aging Process,” J. Neurosci. Res. 88, 3498-3507 (2010).

486. F. Di Domenico, J.B. Owen, R. Sultana, R.A. Sowell, M. Perluigi, C. Cini, J. Cai, W.M. Pierce, and D.A. Butterfield, “The Wheat Germ Agglutinin-Fractionated Proteome of Subjects with Alzheimer's Disease and Mild Cognitive Impairment Hippocampus and Inferior Parietal Lobule: Implications for Disease Pathogenesis and Progression,” J. Neurosci. Res. 88, 3566-3577 (2010).

485. F. Di Domenico, G. Casalena, R. Sultana, J. Cai, W.M Pierce, M. Perluigi, C. Cini, A. Baracca, G. Solaini, G. Lenaz, J. Jia, S.Dziennis, S.J. Murphy, N.J. Alkayed, and D.A. Butterfield, “Involvement of STAT3 in Mouse Brain Development and Sexual Dimorphism: A Proteomics Approach,” Brain Research 1362, 1-12 (2010).

484. R.E. Haskew-Laytona, J.B. Payappilly, N.A. Smirnova, T.C. Ma, K.K. Chan, T.H. Murphy, H. Guo, B. Langley, R. Sultana, D.A. Butterfield, S. Santagata, M.J. Alldred, I.G. Gazaryan, G.W. Bell, S.D. Ginsberg, and R.R. Ratan, “Controlled Enzymatic Production of Astrocytic Hydrogen Peroxide Protects Neurons From Oxidative Stress Via An Nrf2-Independent Pathway,” Proceedings of the National Academy of Sciences USA, 107, 17385-17390 (2010).

483. J.B. Owen, R. Sultana, C.D. Aluise, M.A. Erickson, T.O. Price, G. Bu, W.A. Banks, and  D.A. Butterfield, “Oxidative Modification to LDL-related Receptor Protein 1 (LRP1) in Hippocampus From Subjects with Alzheimer's Disease: Implications for Aβ Accumulation in AD Brain,” Free Radical Biology and Medicine 49, 1798-1803 (2010).

482. G. Cenini, G. Maccarinelli, C. Lanni, S.A. Bonini, G. Ferrari-Toninelli, S. Govoni, M. Racchi, D.A. Butterfield, M. Memo, and D. Uberti, “Wild Type But Not Mutant APP is Involved in Protective Adaptive Responses Against Oxidants,” Amino Acids 39, 271-283 (2010).

481. J.B. Owen and D.A. Butterfield, "Measurement of Oxidized/Reduced Glutathione Ratio," Meth. Molec. Biol. 648, 269-277 (2010).

480. Q. Huang, C, Aluise, G. Joshi, R. Sultana, D. St. Clair, W. Markesbery, and D.A. Butterfield, "Potential In Vivo Amelioration By N-Acetyl-L-Cysteine of Oxidative Stress in Brain in Human Double Mutant APP/PS-1 Knock-In Mice: Towards Therapeutic Modulation of Mild Cognitive Impairment (MCI),"  Journal of Neuroscience Research 88, 2618-2629 (2010).

479. S.S. Hardas, D.A. Butterfield, R. Sultana, M. Dan, R.L. Florence, J.M. Unrine, U.M. Graham, P. Wu, E.A. Grulke, M.T. Tseng, and R.A. Yokel, “Brain Distribution and Toxicological Evaluation of a Systemically Delivered Engineered Nanoscale Ceria,” Toxicological Sciences 116, 562-576 (2010).

478. D.A. Butterfield, M.L. Bader Lange, and R. Sultana, "Involvements of the Lipid Peroxidation Product, HNE, in the Pathogenesis and Progression of Alzheimer's Disease," Biochimica et Biophysica Acta 1801, 924-929 (2010).

477. C.D. Aluise, R. Sultana, J. Tangpong, M. Vore, D. St. Clair, J.A. Moscow, and D.A. Butterfield, "Chemo Brain (Chemo Fog) as a Potential Side Effect of Doxrubicin Administration: Role of Cytokine-induced, Oxidative/Nitrosative Stress in Cognitive Dysfunction," in Chemo-Fog (ed by R.B. Faffa and R.J. Tallarida), Landes Bioscience,Austin, TX pp 147-156 (2010).

476. C.D. Aluise, R.A.S. Robinson, T.L. Beckett, M.P. Murphy, J. Cai, W.M. Pierce, W.R. Markesbery, and D.A. Butterfield, Preclinical Alzheimer Disease: Brain Oxidative Stress, Aβ Peptide and Proteomics,” Neurobiology of Disease 39, 221-228 (2010).

475. D.A. Butterfield, S.S. Hardas, and M.L. Bader Lange, “Oxidatively Modified Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) and Alzheimer Disease: Many Pathways to Neurodegeneration,” Journal of Alzheimer’s Disease 20, 369-393 (2010).

474. M. Perluigi, F. Di Domenico, C. Blarzino, C. Foppoli, C. Cini, A. Giorgi, C. Grillo, F. De Marco, D.A. Butterfield, M.E. Schininna, and R. Coccia, “Effects of UVB-Induced Oxidative Stress on Protein Expression and Specific Protein Oxidation in Normal Human Epithelial Keratinocytes: A Proteomics Approach,” Proteome Science 8, 13-26 (2010).

473. F. Di Domenico, R. Sultana, G.F. Tiu, N.N. Scheff, M. Perluigi, C. Cini, and D.A. Butterfield, “Protein Levels of Heat Shock Proteins 27, 32, 60, 70, 90 and Thioredoxin-1 in Amnestic Mild Cognitive Impairment: An Investigation on the Role of Cellular Stress Response in the Progression of Alzheimer's Disease,” Brain Research 1333, 72-81 (2010).

472. D.A. Butterfield, "William R. Markesbery, M.D.: A Legacy of Excellence in Alzheimer's Disease Research and a Life Well Lived," Journal of Alzheimre's Disease 20, 3-4 (2010).

471. M.L. Lange, D.K. St. Clair, W.R. Markesbery, C.M. Studzinski, M.P. Murphy, and D.A. Butterfield, “Age-Related Loss of Phospholipid Asymmetry in APPNLh/APPNLh x PS-1P264L/PS-1P264L Human Double Mutant Knock-In Mice: Relevance to Alzheimer Disease,” Neurobiology of Disease 38, 104-115 (2010).

470. G. Joshi, C. D. Aluise, M.P. Cole, R. Sultana, M. Vore, D.K. St. Clair, and D.A. Butterfield, “Alterations in Brain Antioxidant Enzymes and Redox Proteomic Identification of Oxidized Brain Proteins Induced by the Anti-Cancer Drug Adriamycin: Implications for Oxidative Stress-Mediated Chemobrain,” Neuroscience 166, 796-807 (2010).

469. R. Sultana, M. Perluigi, S. Newman, W. Pierce, C. Cini, R. Coccia, and D.A. Butterfield, "Redox Proteomic Analysis of Carbonylated Brain Proteins in Mild Cognitive Impairment and Early Alzheimer's Disease," Antioxidants and Redox Signaling 12, 327-336 (2010).

468. Y.J. Suzuki, M. Carini, and D.A. Butterfield, “Protein Carbonylation,” Antioxidants and Redox Signaling 12, 323-325 (2010).

467. R. Sultana, W.A. Banks, and D.A. Butterfield, "Decreased Levels of PSD95 and Two Associated Proteins and Increased Levels of BCl2 and Caspase 3 in Hippocampus From Subjects with Amnestic Mild Cognitive Impairment: Insights into Their Potential Roles for Loss of Synapses and Memory, Accumulation of Aβ, and Neurodegeneration in a Prodromal Stage of Alzheimer’s Disease," Journal of Neuroscience Research 88, 469-477 (2010).

466. V. Calabrese, C. Cornelius, C. Mancuso, R. Lentile, A.M. Stella, and D.A. Butterfield, "Redox Homeostasis and Cellular Stress Response in Aging and Neurodegeneration," Meth. Molec. Biol. 610, 285-308 (2010).

465. D.A. Butterfield, V. Galvan, M. Bader Lange, H. Tang, R.A. Sowell, P. Spilman, J. Fombonne, O. Gorostiza, J. Zhang, R. Sultana, and D.E. Bredesen, "In Vivo Oxidative Stress in Brain of Alzheimer Disease Transgenic Mice: Requirement for Methionine 35 in Amyloid β-Peptide of APP," Free Radic Biol Med 48, 136-144 (2010).

464. T.T. Reed, R. Sultana, and D.A. Butterfield, “Redox Proteomics of Oxidatively Modified Brain Proteins in Mild Cognitive Impairment,” in Neuroproteomics (O. Alzate, Editor), Taylor and Francis Publishers, Boca Raton, FL, pp. 163-195 (2010).

463. R. Sultana and D.A. Butterfield., “Role of Oxidative Stress in the Progression of Alzheimer's Disease,”Journal of Alzheimer’s Disease 19, 341-353 (2010).>

462. V. Calabrese, R. Lentile, C. Cornelius, M. Scalia, M.T. Cambria, B. Ventimiglia, G. Pennisi, C. Mancuso, and D.A. Butterfield, “Nutritional redox homeostasis and cellular stress response: differential role of homocysteine and acetylcarnitine,” Oxid. Stress Dis., 25, 229-250 (2009).

461. D.A. Butterfield and H. Mohmmad Abdul, "Lipids in Alzheimer's Disease Brain," in Handbook of Neurochemistry and Molecular Neurobiology (A.Lajtha, Ed.), Springer Publishing, New York, pp. 563-582 (2009).

460. T.T. Reed, W.M. Pierce Jr., D.M. Turner, W.R. Markesbery, and D.A. Butterfield, “Proteomic Identification of Nitrated Brain Proteins in Early Alzheimer’s Disease Inferior Parietal Lobule,” Journal of Cellular and Molecular Medicine 8B, 2019-2029 (2009).

459. R. Sultana and D.A. Butterfield, “Oxidatively Modified, Mitochondria-Relevant Brain Proteins in Subjects with Alzheimer Disease and Mild Cognitive Impairment,”