658. D.A. Butterfield, M. Bing, Q. Peng, S. Hardas, J. Unrine, E. Grulke, U. Graham, M. Tseng, J. Cai, J.B. Klein, D. Pears, R.A. Yokel, and R. Sultana, “Identification of Serum or Plasma Proteins Bound to Nanoceria Using a Proteomics Approach: Insights into Potential Pathways by which Ceria NPs May Exert Beneficial or Deleterious Effects in vivo,” Manuscript in Preparation (2018).
657. X. Ren, J. Keeney, S. Miriyala, T. Noel, D. Powell, S. Bondada, D. St. Clair, and D.A. Butterfield, “The Triangle of Death of Neurons, Oxidative Damage, Mitochondrial Dysfunction, and Loss of Choline-Containing Biomolecules, in Brains of Mice Treated with Doxorubicin: Advanced Insights into Mechanisms of Chemotherapy Induced Cognitive Impairment (“Chemobrain”) Involving TNF-alpha,” Submitted for Publication (2018).
656. A. Tramutola, G. Abate, C. Lanzillotta, F. Triani, E. Barone, F. Iavarone, F. Vincenzoni, M. Castagnola, M. Marziano, M. Memo, E. Garrafa, D.A. Butterfield, M. Perluigi, F. Di Domenico, and Daniela Uberti, “Redox Proteomics Analysis of 3-NT-modified Proteins in T Cells from Alzheimer Disease Patients: Involvement in Immunosenescence and/or Pathology Prediction,” Submitted for Publication (2018).
655. A.Tramutola, C. Lanzillotta, E. Barone, A. Arena, I. Zuliani, L. Mosca, C. Blarzino, D.A. Butterfield, M. Perluigi, and F. Di Domenico, “Intranasal Rapamycin Ameliorates Alzheimer-like Cognitive Decline in a Mouse Model of Down Syndrome,” Submitted (2018).
654. D.A. Butterfield and B. Halliwell, “Oxidative Stress, Glucose Dysmetabolism and Alzheimer Disease,” Submitted (2018).
653. T. Salameh, W. Mortell, A. Logsdon, D.A. Butterfield, and W. Banks, “Disruption of the Hippocampal and Hypthalamic Blood-brain Barrier in a Diet-induced Obese Model of Type II Diabetes: Prevention and Treatment by the Mitochondrial Carbonic Anhydrase Inhibitor, Topiramate,” Submitted (2018).
652. E.N. Wilson, S. Do Carmo, M.F. Iulita, H. Hall, G.L. Austin, D.T. Jia, J.C. Malcolm, D.A. Butterfield, and C.Cuello, “Microdose Lithium NP03 Diminishes Pre-Plaque Oxidative Damage and Neuroinflammation in Alzheimer rat,” Submitted (2018).
651. L. Liu, L. Qi, T. Knifley, D. Piecoro, P. Rychahou, J. Liu, M. Mitov, C. Wang, J. Wu, H. Weiss, D.A. Butterfield, B. M. Evers, K. O’Connor, and M. Chen, “S100A4 Enhances Cellular Respiration to Promote Invasive and Metastatic Capacity of Lung Cancer Cells Through Upregulation of NDUFS2,” Submmited (2018).
650. D.A. Butterfield and D. Boyd-Kimball, “Redox Proteomics and Amyloid β-Peptide: Insights into Alzheimer Disease,” J. Neurochem., Minor Revision (2018).
649. E. Barone, A. Tramutola, F. Triani, S. Calcagnini, F. Di Domenico, C. Ripoli, S. Gaetani, C. Grassi, D.A. Butterfield, T. Cassano, and M. Perluigi, “Biliverdin Reductase-A Mediates the Beneficial Effects of Intranasal Insulin in Alzheimer Disease” Molecular Neurobiology, in press (2018).
648. A. Tramutola, N. Sharma, E. Barone, C. Lanzillotta, A. Castellani, F. Iavarone, F. Vincenoni, M. Castagnola, D.A. Butterfield, S. Gaetani, T. Cassano, M. Perluigi, and F. Di Domenico, “Proteomic Identification of Altered Protein O-GlcNAcylation Profile in a Triple Transgenic Mouse Model of Alzheimer’s Disease. Biochimica et Biophysica Acta—Molecular Basis of Disease 1864, 3309-3321 (2018).
647. F. Triani, A. Tramutola, F. Di Domenico, N. Sharma, D.A Butterfield, E. Head, M. Perluigi, and E. Barone, “Biliverdin Reductase-A Impairment Links Brain Insulin Resistance with Increased A Production in an Animal Model of Aging: Implications for Alzheimer Disease,” Biochimica et Biophysica Acta—Molecular Basis of Disease 1864, 3181-3194 (2018).
646. J.T.R. Keeney, X. Ren, G. Warrier, T. Noel, D.K. Powell, J.M. Brelsfoard, R. Sultana, K.E. Saatman, D.K. St. Clair, and D.A. Butterfield, “Doxorubicin-induced Elevated Oxidative Stress and Neurochemical Alterations in Brain and Cognitive Decline: Protection by MESNA and Insights into Mechanisms of Chemotherapy-induced Cognitive Impairment (“Chemobrain”),” Oncotarget 9, 30324-30339 (2018).
645. A. Tramutola, F. Triani, F. Di Domenico, E. Barone, M. Perluigi, and D.A. Butterfield, “Poly-ubiquitin Profile in Alzheimer Disease Brain,” Neurobiology of Disease 118, 129-141 (2018).
644. D.A. Butterfield, “Perspectives on Oxidative Stress in Alzheimer Disease and Predictors of Future Research Emphases,” Journal of Alzheimer’s Disease 64, S469-S479 (2018).
643. C. Yarana, D. Carroll, J. Chen, L. Chaiswing, Y. Zhao, T. Noel, M. Alstott, Y. Bae, E. Dressler, J. Moscow, D.A. Butterfield, H. Zhu, and D. St. Clair, “Extracellular Vesciles Released by Cardiomyocytes in a Doxorubicin-Induced Cardiac Injury Mouse Model Contain Protein Biomarkers of Early Cardiac Injury,” Clinical Cancer Research 24, 1644-1553 (2018).
642. D.A. Butterfield and D. Boyd-Kimball, “Oxidative Stress, Amyloid beta-Peptide, and Altered Key Molecular Pathways in the Pathogenesis and Progression of Alzheimer Disease,” Journal of Alzheimer’s Disease 62, 1345-1367 (2018).
641. F. Di Domenico, A. Tramutola, C. Foppoli, E. Head, M. Perluigi, and D.A. Butterfield, “mTOR in Down Syndrome: Role in A and Tau Neuropathology and Transition to Alzheimer Disease-like Dementia,” Free Radical Biology & Medicine 114, 94-101 (2018).
640. E. Barone, A. Arena, E. Head, D.A. Butterfield, M. Perluigi, “Disturbance of Redox Homestasis in Down Syndrome: Role of Iron Dysmetabolism,” Free Radical Biology & Medicine 114, 84-93 (2018).
639. D.A. Butterfield and M. Perluigi, “Down Syndrome: From Development to Adult Life to Alzheimer Disease,” Free Radical Biology and Medicine 114, 1-2 (2018).
638. D. Arndt, E.K. Oostveen, J. Triplett, D.A. Butterfield, O.V. Tsyusko, B.E. Collin, D.L. Starnes, J. Cai, J.B. Klein, R. Nass, and J.M. Unrine, “The Role of Charge in the Toxicity of Polymer-coated Cerium Oxide Nanomaterials to Caenorhabditis elegans,” Comp Biochem Physiol C: Toxicol Pharmacol 201, 1-10 (2017).
637. T.C. Thomas, J.A. Beitchman, F. Pomerleau, T. Noel, P. Jungsuwadee, D.A. Butterfield, D.K. St. Clair, M. Vore, G.A. Gerhardt, “Acute Treatment with Doxorubicin Affects Glutamate Neurotransmission in the Mouse Frontal Cortex and Hippocampus,” Brain Research, 1672, 10-17 (2017).
636. V. Vilchez. L. Turcios, D.A. Butterfield, M.I. Mitov, C.L. Coquillard, J.A. Brandon, V. Cornea, R. Gedaly, and F. Marti, “Evidence of the Immunomodulatory Role of Dual PI3K/mTOR Inhibitors in Transplantation: An Experimental Study in Mice,” Transplant International 30, 1061-1074 (2017).
635. J. Zhang and D.A. Butterfield, “Oxidative Stress and Neurodegeneration,” Brain Research Bullein 133, 1-3 (2017).
634. L. Turcios, V. Vilchez, L.F. Acosta, P. Poyil, D.A. Butterfield, M. Mitov, F. Marti and R. Gedaly, “Sorafenib and FH535 in Combination Act Synergistically on Hepatocellular Carcinoma by Targeting Cell Bioenergetics and Mitochondrial Function,” Digestive and Liver Disease 49, 697-704 (2017).
633. T.T. Reed and D.A. Butterfield, “Protein Carbonylation in Brains of Subjects with Selected Neurodegenerative Disorders,” in Protein Carbonylation: Principles, Analysis, and Biological Implications (J. Ros, Ed.). John Wiley & Sons, Hoboken, NJ, pp. 167-205 (2017).
632. A. Tramutola, C. Lanzillotta, M. Perluigi, and D.A. Butterfield, “Oxidative Stress, Protein Oxidation, and Alzheimer Disease,” Brain Research Bulletin 133, 88-96 (2017).
631. E. Barone, E. Head, D.A. Butterfield, and M. Perluigi, “HNE-modified Proteins in Down Syndrome: Involvement in development of Alzheimer disease neuropathology,” Free Radical Biology and Medicine 111, 262-269 (2017).
630. F. Di Domenico, A. Tramutola, and D.A. Butterfield, “Role of 4-Hydroxy-2-Nonenal (HNE) in the Pathogenesis of Alzheimer Disease and Other Selected Age-Related Neurodegenerative Disorders,” Free Radical Biology and Medicine 111, 253-261 (2017)
629. M. Mitov, J.W. Harris, M.C. Alstott, B.M. Evers, and D.A. Butterfield, “Temperature Induces Significant Changes in both Glycolytic Rerserve and Mitochondrial Spare Respiratory Capacity in Colorectal Cancer Cell Lines,” Experimental Cell Research 354, 112-121 (2017).
628. E.M. Palmieri, A. Menga, A. Lebrun, D.C. Hooper, D.A. Butterfield, M. Mazzone, and A. Castegna, “Blockade of Glutamine Synthetase Strongly Enhances Inflammatory Response in Microglial Cells,” Antioxidants and Redox Signaling 26, 351-363 (2017).
627. F. Di Domenico, E. Barone, M. Perluigi 1 and D.A.Butterfield, “The Triangle of Death in Alzheimer Disease Brain: The Aberrant Cross Talk Among Energy Metabolism, mTOR Signaling and Protein Homeostasis Revealed by Redox Proteomics," Antioxidants and Redox Signaling 26, 364-387 (2017).
626. A. Tramutola, A. Arena, C. Cini, D.A. Butterfield, and Eugenio Barone, “Modulation of GLP-1 Signaling as a Novel Therapeutic Approach in the Treatment of Alzheimer Disease Pathology,” Expert Reviews of Neurotherapeutics 17, 59-75 (2017).
625. A. Tramutola, F. Di Domenico, E. Barone, A. Giorgi, L. di Francesco, M.E. Schinina, R. Coccia, E. Head, D.A. Butterfield*, and M. Perluigi, “Polyubiquityinylation Profile in Down Syndrome Brain Prior to and after Development of Alzheimer Neuropathology,” Antioxidants and Redox Signaling 26, 280-298 (2017). *Co-Corresponding Author.
624. D.A. Butterfield and M. Perluigi, “Redox Proteomics: A Key Tool for New Insights into Protein Modification with Relevance to Disease,” Antioxidants and Redox Signaling 26, 277-279 (2017).
623. X. Ren, D.K. St. Clair, and D.A. Butterfield, “Dysregulation of cytokine mediated chemotherapy induced cognitive impairment,” Pharmacological Research 117, 267-273 (2017).
622. A.M. Swomley, J.C. Triplett, J.T. Keeney, G. Warrier, K.J. Pearson, J.A. Mattison, R. de Cabo, J. Cai, J.B. Klein, and D.A. Butterfield, “Comparative Proteomic Analyses of the Parietal Lobe from Rhesus Monkeys Fed a High Fat/Sugar Diet with and without Resveratrol Supplementation, Relative to a Healthy Diet: Insights into Role of Unhealthy Diets and Resveratrol on Function,” Journal of Nutritional Biochemistry 39, 169-179 (2017).
621. D.A. Butterfield and T.T. Reed, “Lipid Peroxidation and Tyrosine Nitration in Traumatic Brain Injury: Insights into Secondary Injury from Redox Proteomics,” Proteomics-Clinical Applications 10, 1191-1204 (2016).
620. S.A. Farr, M.L. Niehoff, M.A. Ceddia, K.A. Herrlinger, B.J. Lewis, S. Feng, A. Welleford, D.A. Butterfield, and J.E. Morley, “ Effect of Botanical Extracts Containing Carnosic Acid or Rosmarinic Acid on Learning and Memory in SAMP8 Mice,” Physiology & Behavior 165, 328-338 (2016).
619. P. Gupta, C.T. Jordan, M.I. Mitov, D.A. Butterfield, J.Z. Hilt, T.D. Dziubla, “Controlled Circumin Release via Conjugation intp PBAE Nanogels Enhances Mitochondrial Protection Against Oxidative Stress,” International Journal of Pharmaceutics 511, 1012-1021 (2016).
618. A.-L, Lin, D.A. Butterfield, and A. Richardson, “mTOR: Alzheimer’s Disease Prevention for APOE4 Carriers,” Oncotarget 7, 44873 (2016).
617. M. Perluigi, F. Di Domenico, E. Barone, and D. A. Butterfield, “Abberant Protein Phosphorylation in Alzheimer Disease Brain Disturbs Pro-Survival and Cell Death Pathways,” Biochimica et Biophysica Acta-Moleclar Basis of Disease 1862, 1871-1882 (2016).
616. M. Mitov, V.S. Patil, M.C. Alstott, T. Dziubla, and D.A. Butterfield, “In Vitro Cellular Assays for Oxidative Stress and Biomaterial Response,” in Oxidative Stress and Biomaterials, (T. Dziubla and D.A. Butterfield, Eds.), Elsevier Press, Amsterdam, pp. 145-186 (2016).
615. T. Dziubla, and D.A. Butterfield, Oxidative Stress and Biomaterials, Elsevier Press, Amsterdam (2016).
614. W. Zhang, D. St. Clair, D.A. Butterfield, and M. Vore,“Loss of Mrp1 Potentiates Doxorubicin-induced Cytotoxicity in Neonatal Mouse Cardiomyocytes and Cardiac Fibroblasts,” Toxicological Sciences 151, 44-56 (2016).
613. A. Tramutola, G. Pupo, F. Di Domenico, E. Barone, A. Arena, C. Lanzillotta, D. Brokeaart, C. Blarzion, E. Head, D.A. Butterfield, and M. Perluigi, “Activation of p53 in Down Syndrome and in the Ts65Dn Mouse Brain Is Associated with a Pro-apoptotic Phenotype,” Journal of Alzheimers Disease 52, 359-371 (2016).
612. J.C. Triplett, A. Swomley, J. Kirk, K. Grimes, K.atilyn Lewis, M. Orr, K. Rodriguez, J. Cai, J.B. Klein, R. Buffenstein, and D.A. Butterfield,“Reaching Out to Send a Message: Mechanisms Promoting Extended Healthspan in the Long-lived Naked Mole-Rat May Involve Neurite Outgrowth and Neurotransmission,” Neurochemical Research 41, 1625-1634 (2016).
611.D.A. Butterfield, Erika M. Palmieri, and A.Castegna, “Clinical Implications From Proteomic Studies In Neurodegenerative Diseases: Lessons From Mitochondrial Proteins,” Expert Rev Proteomics, 13, 259-274 (2016).
610. F. Di Domenico, G. Pupo, E. Giraldo, A. Lloret, M.C. Badia, M.E. Schinina, A. Giorgi,D. A. Butterfield, J. Vina, M. Perluigi, “Autoantibodies Profile in Matching CSF and Serum from AD and aMCI patients: Potential Pathogenic Role and Link to Oxidative Damage,” Curr Alzheimer’s Res 13, 112-122 (2016).
609. A. Tramutola, F. Di Domenico, E. Barone, M. Perluigi, and D.A. Butterfield, “It’s All About U(biquitin): Role of the Altered Ubiquitin Proteasome System and UCHL1 in Alzheimer Disease,” Oxidative Medicine and Cellular Longevity 2016, (2016).
608. S. Miriyala, C. Thippakorn, L. Chaiswing, Y. Xu, T. Noel, A. Tovmasyan, I. Batinic-Haberle, C. Vander Kooi, W. Chi, A. Abdel Latif, M. Panchatcharam, V. Prachayasittikul, D.A. Butterfield, M. Vore, J. Moscow, and Daret K. St. Clair, “ Novel Role of 4-Hydroxy-2-Nonenal in AIFm2-Mediated Mitochondrial Stress Signaling,” Free Radical Biology & Medicine 91, 68-80 (2016).
607. E. Barone, F. Di Domenico, T. Cassano, A. Arena, A. Tramutola, R. Coccia, D.A. Butterfield*, and M. Perluigi, “Impairment of Biliverdin Reductase-A Promotes Brain Insulin Resistance in Alzheimer Disease: A New Paradigm,” Free Radical Biology & Medicine 91, 127-142 (2016).*Co-Corresponding Author.
606. F. Di Domenico, G. Pupo, E. Giraldo, M.-C. Badia, P. Monllor, A. Lloret, M.E. Schinina, A. Giorgi, A. Tramutola, D.A. Butterfield, J. Vina, and M. Perluigi, “Oxidative Signature of Cerebrospinal Fluid from Mild Cognitive Impairment and Alzheimer Disease Patients,” Free Radical Biology & Medicine 91, 1-9 (2016).
605. F. Di Domenico, M. Perluigi, and ,D.A. Butterfield, "Redox Proteomics in Human Biofluids: Sample Preparation, Separation, and Immunochemical Tagging for Analysis of Protein Oxidation” Methods in Molecular Biology 1303, 391-403 (2016).
604. D.A. Butterfield, “Redox Signaling in Neurodegeneration,” Neurobiology of Disease 84, 1-3 (2015).
603. Jeriel T. Keeney and D.A. Butterfield, “Vitamin D Deficiency and Alzheimer Disease: Common Links,” Neurobiology of Disease 84, 84-98 (2015).
602. M. Perluigi, F. Di Domenico, and D.A. Butterfield, “mTOR Signaling in Aging and Neurodegeneration: At the Crossroads between Metabolism Function and Impairment of Autophagy,” Neurobiology of Disease 84, 39-49 (2015).
601. E. Barone and D.A. Butterfield, “Insulin Resistance in Alzheimer Disease: Is Heme Oxygenase-1 an Achille’s Heel?” Neurobiology of Disease 84, 69-77 (2015).
600. J.C. Triplett, A.M. Swomley, J. Cai, J.B. Klein, and D.A. Butterfield, “Quantitative Phosphoproteomic Analyses of the Inferior Parietal Lobule from Three Different Pathological Stages of Alzheimer’s Disease," Journal of Alzheimer’s Disease 49, 45-62 (2016).
599. A.M. Swomley and D.A. Butterfield, “Oxidative Stress in Alzheimer Disease and Mild Cognitive Impairment: Evidence from Human Data Provided by Redox Proteomics,” Archives of Toxicology 89, 1669-1680 (2015).
598. E. Barone, G. Cenini, F. Di Domenico, T. Noel, C. Wang, M. Perluigi , D.K. St. Clair, and D.A. Butterfield, “Basal Brain Oxidative and Nitrosative Stress Levels Are Finely Regulated by the Interplay between MnSOD and p53,” J. Neurosci. Res. 93, 1728-1739 (2015).
597. F. Di Domenico, M. Perluigi, and D.A. Butterfield, "Redox Proteomics in Human Biofluids: Sample Preparation, Separation, and Immunochemical Tagging for Analysis of Protein Oxidation,” Methods in Molecular Biology 1303, 391-403 (2015).
596. Y. Zaytseva, J.W. Harris, M.I. Mitov, J.T. Kim, D.A. Butterfield, E.Y. Lee, H.L. Weiss, T. Gao, and B.M. Evers, “Increased Expression of Fatty Acid Synthase Provides a Survival Advantage to Colorectal Cancer Cells via Upregulation of Cellular Respiration,” Oncotarget 6, 18891-18904 (2015).
595. J.C. Triplett, A. Tramutola, A. Swomley, J. Jirk, K. Grimes, L. Lewis, M. Orr, K. Rodriguez, J. Cai, J.B. Klein, M. Perluigi, R. Buffenstein and D. A. Butterfield, “Age-related Changes in the Proteostasis Network in the Brain of the Naked Mole-rat: Implications Promoting Healthy Longevity,” Biochimica et Biophysica Acta-Molecular Basis of Disease 1852, 2213-2224 (2015).
594. J.T.R. Keeney, S. Miriyala, T. Noel, J.A. Moscow, D.K. St. Clair, and D.A. Butterfield, "Superoxide Induces Protein Oxidation in Plasma and TNF-α Elevation in Macrophage Culture: Insights into Mechanisms of Neurotoxicity Following Doxorubicin Chemotherapy,” Cancer Letters 367, 157-161 (2015).
593. J. C. Triplett, A. Swomley, J. Kirk, K. Lewis, M. Orr, K. Rodriguez, J. Cai, J.B. Klein, R. Buffenstein, and D.A. Butterfield, “Metabolic Clues to Salubrious Longevity in the Brain of the Longest-lived Rodent: the Naked Mole-Rat,” Journal of Neurochemistry 134, 538-550 (2015).
592. C.–H. Chen, W. Li, R. Sultana, M.-H. You, A. Kondo, K. Shahpasand, B.M. Kim, M. Luo, M. Nechama, Y.-M. Lin, Y. Yao, T.H. Lee, X.Z. Zhou, A.M. Swomley, D.A. Butterfield, Y. Zhang, and K.P. Lu, “Pin 1 Cysteine-113 Oxidative Inhibits Its Catalytic Activity and Cellular Function in Alzheimer’s Disease,” Neurobiology of Disease," Neurobiology of Disease 76, 13-23 (2015).
591. J. Hayslip, E.V. Dressler, H. Weiss, T.J. Taylor, M. Chambers T. Noel, S. Miriyala, J.T.R. Keeney, X. Ren, R. Sultana, M. Vore, D.A. Butterfield, D. St. Clair, and J.A. Moscow, “Plasma TNF-a and Soluble TNF Receptor Levels after Doxorubicin with or without Co-administration of Mesna—A Randomized Cross-over Clinical Study,” PLoS One 10, e124988 (2015).
590. J. Triplett, Z. Zhang, R. Sultana, J. Cai, J. Klein, H. Büeler, and D.A. Butterfield, "Quantitative Expression Proteomics and Phosphoproteomics Profiles of Brain from PINK1 Knockout Mice: Insights into Mechanisms of Familial Parkinson Disease," J Neurochem 133, 750-765 (2015).
589. A. Tramutola, J. Triplett, F. Di Domenico, D.M. Niedowicz, M.P. Murphy, R. Coccia, M. Perluigi, and D.A. Butterfield, “Alteration of mTOR Signaling Occurs Early in the Progression of Alzheimer Disease: Analysis of Brain from Subjects with Preclinical AD, Amnestic Mild Cognitive Impairment and Late-Stage AD,” J Neurochem 133, 739-749 (2015).
588. F. Di Domenico, G. Pupo, C. Mancuso, E. Barone, F. Paolini, A. Arena, C. Blarzino, F.A. Schmitt, E. Head, D.A. Butterfield, and M. Perluigi, “Bach1 Overexpression in Down Syndrome Correlates with the Alteration of the HO-1/BVR-A System: Insights for Transition to Alzheimer Disease,” Journal of Alzheimer’s Disease 44, 1107-1120 (2015).
587. F. Di Domenico, E. Barone, M. Perluigi, and D.A. Butterfield, “Strategy to Reduce Free Radical Species in Alzheimer’s Disease: An Update of Selected Antioxidants,” Expert Review of Neurotherapeutics 22, 1-22 (2014).
586. T.T. Reed, Z.P. Sellers, and D.A. Butterfield, "Lipid Peroxidation in Age-related Neurodegenerative Disorders," in Lipid Oxidation in Health and Disease," C.M. Spickett and H.J. Forman, Eds., Taylor and Francis Publishers, Boca Raton, FL., pp. 329-361 (2015).
585. M. Perluigi and D.A. Butterfield, “Down Syndrome as a Special Case of Oxidatively Induced Developmental Dysregulation,” in Perinatal and Prenatal Disorders, P.A. Dennery, G. Buonocore, and O.D. Saugstad, Eds., Springer, New York, pps. 127-142 (2014).
584. G. Cenini, A. Fiorini, R. Sultana, M. Perluigi, J. Cai, J.B. Klein, E. Head, and D.A. Butterfield, “An Investigation of the Molecular Mechanisms Engaged Before and After the Development of Alzheimer Disease Neuropathology in Down Syndrome: A Proteomics Approach,” Free Radical Biology & Medicine 76, 89-95 (2014).
583. D.A. Butterfield, F. Di Domenico, A.M. Swomley, E. Head, and M. Perluigi, “Redox Proteomics Analysis to Decipher the Neurobiology of Alzheimer-like Neurodegeneration: Overlaps in Down Syndrome and Alzheimer Disease Brain,” Biochemical Journal 463, 177-189 (2014).
582. S.S. Hardas, R. Sultana,W. Govind, M. Dan, P. Wu, E. Grulke, M. Tseng, J. Unrine, U. Graham, R. Yokel, and D.A. Butterfield, “Rat Hippocampal Responses Up to 90 Days after a Single Nanoceria Dose Extends a Hierarchical Oxidative Stress Model for Nanoparticle Toxicity,” Nanotoxicology 81, 155-166 (2014).
581. M.T. Tseng, Q. Fu, K. Lor, R. Fernandez-Botron, Z.B. Deng, U.M. Graham, D.A. Butterfield, E. Grulke, and R.A. Yokel, "Persistent Hepatic Structural Alterations Following Nanoceria Vascular Infusion in the Rat," Toxicologic Pathology 42, 984-996 (2014).
580. U.M. Graham, M.T. Tseng, J.B. Jasinski, R.A. Yokel, J.M. Unrine, B.H. Davis, A.K. Dozier, S.S. Hardas, R. Sultana, E.A. Grulke, and D.A. Butterfield, “In Vivo Processing of Ceria Nanoparticles Inside Liver: Impact on Free Radical Scavenging Activity and Oxidative Stress,” ChemPlusChem 79, 1083-1089 (2014).
579. D.A. Butterfield, “THE 2013 SFRBM DISCOVERY AWARD: Selected Discoveries from the Butterfield Laboratory of Oxidative Stress and Its Sequela in Brain in Cognitive Disorders Exemplified by Alzheimer Disease and Chemotherapy Induced Cognitive Impairment,” Free Radical Biology & Medicine 74, 157-174 (2014).
578. D. A. Butterfield, Fabio Di Domenico, and Eugenio Barone, "Elevated Risk of Type 2 Diabetes for Development of Alzheimer Disease: a Key Role for Oxidative Stress in Brain," Biochimica et Biophysica Acta - Molecular Basis of Disease 1842, 1693-1706 (2014).
577. F. Di Domenico, E. Head, D.A. Butterfield, and M. Perluigi, "Oxidative Stress and Proteostasis Network: Culprit and Casualty of Alzheimer’s-Like Neurodegeneration," Advances in Geriatrics 2014, 1-14 (2014).
576. S. Förster, A.S. Welleford, J.C. Triplett, R. Sultana, B. Schmitz, and D.A. Butterfield, “Increased O-GlcNAc Levels Correlate with Decreased O-GlcNAcase Levels in Alzheimer Disease Brain,” Biochimica et Biophysica Acta - Molecular Basis of Disease 1842, 1333-1339 (2014).
575. A.M. Swomley, S. Forster, J. Keeney, J. Triplett, Z. Zhang, R. Sultana, and D.A. Butterfield, “Abeta, Oxidative Stress in Alzheimer Disease: Evidence Based on Proteomics Studies,” Biochimica et Biophysica Acta 1842, 1248-1257 (2014).
574. D.A. Butterfield, F. Di Domenico, and R.A.S. Robinson, “Mass Spectrometry and Redox Proteomics: Applications in Disease,” Mass Spectrometry Reviews 33, 277-301 (2014).
573. M. Perluigi, G. Pupo, A. Tramutola, C. Cini, R. Coccia, E. Barone, E. Head, D.A. Butterfield, and F. Di Domenico, “Neuropathological Role of PI3K/AKT/mTOR Axis in Down Syndrome Brain,” Biochim. Biophys. Acta-Molec. Basis Dis. 1842, 1144-1153 (2014).
572. F. Di Domenico, G. Pupo, A. Tramutola, A. Giorgi, M. Eugenia Schininà, R. Coccia, E. Head, D.A. Butterfield, and M. Perluigi, “Redox Proteomics Analysis of HNE-Modified Proteins in DS Brain: Clues for Understanding Development of Alzheimer Disease,” Free Radical Biology & Medicine 71, 270-280 (2014).
571. Y. Zhao, S. Miriyala, L. Miao, M. Mitov, D. Schnell, S. Dhar, J. Cai, J.B. Klein, R. Sultana, D.A. Butterfield, M. Vore, S. Bondada, and D.K. St. Clair, ”Redox Proteomic Identification of HNE-bound Mitochondrial Proteins in Cardiac Tissues Reveals a Systemic Effect on Energy Metabolism after Doxorubicin Treatment,” Free Radical Biology & Medicine 72, 55-65 (2014).
570. E. Barone, F. Di Domenico, and D.A. Butterfield, “Statins More Than Cholesterol Lowering Agents in Alzheimer Disease: Their Pleiotropic Functions as Potential Therapeutic Targets” Biochemical Pharmacology 88, 605-616 (2014).
569. M. Perluigi, F. Di Domenico, and D.A. Butterfield “Unraveling the Complexity of Neurodegeneration in Brains of Subjects with Down Syndrome: Insights from Proteomics,” Proteomics Clinical Applications 8, 73-85 (2014).
568. L. Ulatowski, R. Parker, G. Warrier, R. Sultana, D.A. Butterfield, and D. Manor, "Vitamin E is Essential for Purkinje Neuron Integrity," Neuroscience 260, 120-129 (2014).
567. M. Perluigi, A.M. Swomley, and D.A. Butterfield, “Redox Proteomics and the Dynamic Molecular Landscape of the Aging Brain,” Ageing Research Reviews 13, 75-89 (2014).
566. S.A. Farr, J.L. Ripley, R. Sultana, Z. Zhang, M.L. Niehoff, T.L. Platt, M.P. Murphy, J.E. Morley, V. Kumar, and D.A. Butterfield, “Antisense Oligonucleotide Against GSK-3b in Brain of SAMP8 Mice Improves Learning and Memory and Decreases Oxidative Stress: Involvement of Transcription Factor Nrf2 and Implications for Alzheimer Disease,” Free Radical Biology and Medicine 67, 387-395 (2014).
565. D.A. Butterfield and I. Dalle-Donne, "Redox Proteomics: From Protein Modification to Cellular Dysfunction and Disease," Mass Spectrometry Reviews 33, 1-6 (2014).
564. E. Barone, F. Di Domenico, C. Mancuso, and D.A. Butterfield, “The Janus Face of the Heme Oxygenase/Biliverdin Reductase System in Alzheimer Disease: It's Time for Reconciliation,” Neurobiology of Disease 62,144-159 (2014).
563. R. Sultana and D.A. Butterfield, "Oxidative Modification of Brain Proteins in Alzheimer Disease: Prespective on Future Studies Based on Results of Redox Proteomics Studies," Journal of Alzheimer's Disease 33, S243-S251 (2013).
562. V. Makani, R. Sultana, K. Sie, D. Orjiako, M. Tat, A. Dowling, J. Cai, WM Pierce, D.A. Butterfield, J.W. Hill, and J. Park, "Annexin A1 Complex Mediates Oxytocin Vesicle Transport" Journal of Neuroendocrinology 25, 1241-1254 (2013).
561. R. Sultana, A.M. Swomley, and D.A. Butterfield, “Brain Oxidative Stress in the Pathogenesis and Progression of Alzheimer Disease,” in Studies on Alzheimer’s Disease, D. Pratico and P. Mecocci, Eds., Humana Press/Springer, New York, pp. 99-118 (2013).
560. R. Sultana, G. Cenini, and D.A. Butterfield, “Biomarkers of Oxidative Stress in Neurodegenerative Diseases,” in Molecular Basis of Oxidative Stress: Chemistry, Mechanisms, and Disease Pathogenesis, F.A. Villamena, Editor, John Wiley & Sons, Inc., Hoboken, New Jersey, pps. 359-376 (2013).
559. R. Sultana, M. Baglioni, R. Cecchetti, J. Cai, J.B. Klein, P. Bastiani, C. Ruggiero, P. Mecocci, and D.A. Butterfield, “Lymphocyte Mitochondria: Toward Identification of Peripheral Biomarkers in Progression of Alzheimer Disease,” Free Radical Biology & Medicine 65, 595-606 (2013).
558. D.A. Butterfield, A. Swomley, and R. Sultana, "Amyloid β-Peptide 1-42-induced Oxidative Stress in Alzheimer Disease: Importance in Disease Pathogenesis and Progression," Antioxidant Redox Signal 19, 823-835 (2013).
557. J.T. Keeney, S. Forster, R. Sultana, L.D. Brewer, C.S. Latimer, J. Cai, J.B. Klein, N.M Porter, and D.A. Butterfield, "Dietary Vitamin D Deficiency in Rats from Middle- to Old-age Leads to Elevated Tyrosine Nitration and Proteomics Changes in Levels of Key Proteins in Brain: Implications for Low Vitamin D-dependent Age-Related Cognitive Decline," Free Radical Biology and Medicine 65, 324-334 (2013).
556. R. Sultana, M. Perluigi, and D.A. Butterfield, “Lipid Peroxidation Triggers Neurodegeneration: A Redox Proteomics View into the Alzheimer Disease Brain,” Free Radic. Biol. Med. 62, 157-169 (2013).
555. A. Fiorini, R. Sultana, S. Forster, M. Perluigi, G. Cenini, C. Cini, J. Cai, J.B. Klein, S.A. Farr, M.L. Niehoff, J.E. Morley, V.B. Kumar, and D.A. Butterfield, “Antisense Directed Against PS-1 Gene Decreases Brain Oxidative Markers in Aged Senescence Accelerated Mice (SAMP8) and Reverses Learning and Memory Impairment: A Proteomics Study,” Free Radical Biology and Medicine 65, 1-14 (2013).
554. F. Di Domenico, R. Coccia, A. Cocciolo, M.P. Murphy, G. Cenini, E. Head, D.A. Butterfield, A. Giorgi, M.E. Schininà, C. Mancuso, C. Cini, and M. Perluigi, “Impairment of Protestasis Network in Down Syndrome Prior to the Development of Alzheimer’s Disease Neuropathology: Redox Proteomics Analysis of Human Brain,” Biochim. Biophys. Acta—Molec. Basis Dis. 1832, 1249-1259 (2013).
553. R.A.S. Robinson and D.A. Butterfield, "Insights from Proteomics into Mild Cognitive Impairment, Likely the Earliest Stage of Alzheimer's Disease, in Alzheimer's Disease Research Compendium, M.-K. Sun, Ed., Nova Science Publishers, Columbus, OH, pp. 97-116 (2013).
552. S.S. Hardas, R. Sultana, A.M. Clark, C. Bracket, L.I. Szweda, M.P. Murphy, and D. A. Butterfield, “Oxidative Modification of Lipoic Acid by HNE in Alzheimer Disease Brain,” Redox Biology 1, 80-85 (2013).
551. J.T. Keeney, A.M. Swomley, S. Förster, J.L. Harris, R. Sultana, and D.A. Butterfield, “Apolipoprotein A-I: Insights From Redox Proteomics for Its Role in Neurodegeneration,” Proteomics—Clinical Applications 7, 109-122 (2013).
550. P. Jungsuwadee, T. Zhao, E.I. Stolarczyk, C.M. Paumi, D.A. Butterfield, D.K. St..Clair, and M. Vore, “The G671V Variant of MRP1/ABCC1 Links Doxorubicin-Induced Acute Cardiac Toxicity to Disposition of the Glutathione Conjugate of 4-Hydroxy-2-Trans-Nonenal,” Pharmacogenetics and Genomics Journal 22, 273-284 (2012).
549. F. Di Domenico, M. Perluigi, and D.A. Butterfield, “Redox Proteomics Studies on C.elegans Models: A Simple Organism that Provides Insights into Complex Neurodegenerative Disorders,” European Journal of Neurodegenerative Disorders 1, 279-291 (2012).
548. A. Fiorini, R. Sultana, E. Barone, G. Cenini, M. Perluigi, C. Mancuso, J. Cai, J.B. Klein, D. St. Clair, and D.A. Butterfield, “Lack of p53 Affects the Expression of Several Brain Mitochondrial Proteins: Insights From Proteomics into Important Pathways Regulated by p53,” PLoS One 2012;7, e49846 (2012).
547. C. Pocernich, D.A. Butterfield, and L. Head, “Diet and Brain Aging: Effects on Cell and Mitochondrial Function and Structure,” in Bioactive Food as Dietary Interventions for the Aging Population, (R.R. Watson and V.R. Preedy, Eds.), Elsevier Publishers, Amsterdam, 249-262 (2012).
546. R. Sultana, G. Cenini, and D.A. Butterfield, “SAMP8: A Model to Understand the Role of Oxidative Stress in Age-Related Diseases Including Alzheimer’s Disease,” in The Senescence Accelerated Mouse (SAM): Achievements and Future Directions, (T. Takeda, Ed.), Elsevier Publishers, Amsterdam, 361-370 (2012).
545. R. Khanna, S.M. Wilson, J.M. Brittain, J. Weimer, R. Sultana, A. Butterfield, and K. Hensley, “Opening Pandora’s Jar: A Primer on the Putative Roles of CRMP2 in a Panoply of Neurodegenerative, Sensory and Motor Neuron, and Central Disorders,” Future Neurology 7, 749-771 (2012).
544. F. Di Domenico, E. Barone, C. Mancuso, M. Perluigi, A. Cocciolo, P. Mecocci, D.A. Butterfield, and R. Coccia, “HO-1/BVR-A System Analysis in Plasma from Probable Alzheimer's Disease and Mild Cognitive Impairment Subjects: A Potential Biochemical Marker for the Prediction of the Disease,” Journal of Alzheimer's Disease 32, 277-289 (2012).
543. S.S. Hardas, R. Sultana, G. Warrier, M. Dan, R.L. Florence, P. Wu, E.A. Grulke, M.T. Tseng, J.M. Unrine, U.M. Graham, R.A. Yokel, and D.A. Butterfield, “Rat Brain Pro-Oxidant Effects of Peripherally Administered 5 nm Ceria 30 Days After Exposure,” Neurotoxicology 33, 1147-1155 (2012).
542. A. Cocciolo, F. Di Domenico1, R. Coccia, A. Fiorini, J. Cai, W.M. Pierce, P. Mecocci, D.A. Butterfield, and M. Perluigi, “Decreased expression and increased oxidation of plasma haptoglobin in Alzheimer disease: Insights From redox proteomics,” Free Radic. Biol. Med. 53, 1868-1876 (2012).
541. D.A. Butterfield, M. Perluigi, T. Reed, T. Muharib, C. Hughes, R. Robinson, and R. Sultana, “Redox Proteomics in Selected Neurodegenerative Disorders. From its Infancy to Future Applications,” Antioxidants and Redox Signaling 17, 1610-1655 (2012).
540. M. Perluigi, R. Coccia, and D.A. Butterfield, “4-Hydroxy-2-Nonenal, a Reactive Product of Lipid Peroxidation, and Neurodegenerative Diseases: A Toxic Combination Illuminated by Redox Proteomics Studies,” Antioxidants and Redox Signaling 17, 1590-1609 (2012).
539. R. Sultana, R.A.S. Robinson, M. Bader Lange, A. Fiorini, V. Galvan, J. Fombonne, A. Baker, O. Gorostiza, J. Zhang, J. Cai, W. Pierce, D. Bredesen, and D.A. Butterfield, “Do Proteomics Analyses Provide Insights into Reduced Oxidative Stress in Brain of an Alzheimer Disease Transgenic Mouse Model with an M631L Amyloid Precursor Protein Substitution and Thereby the Importance of Amyloid-Beta-Resident Methionine 35 in Alzheimer Disease Pathogenesis?” Antioxidants and Redox Signaling 17, 1507-1514 (2012).
538. F. Di Domeico, R. Sultana, A. Ferree, K. Smith, E. Barone, M. Perluigi, R. Coccia, W. Pierce, J. Cai, C. Mancuso, R. Squillace, M. Weingele, I. Dalle-Donne, B. Wolozin, and D.A. Butterfield, "Redox Proteomics Analyses of the Influence of Co-Expression of Wild Type or Mutated LRRK2 and Tau on C. elegans Protein Expression and Oxidative Modification: Relevance to Parkinson Disease," Antioxidants and Redox Signaling 17, 1490-1506 (2012).
537. D.A. Butterfield and I. Dalle-Donne, "Redox Proteomics," Antioxidants and Redox Signaling 17, 1487-1489 (2012).
536. O.V. Tsyusko, S.S. Hardas, W.A. Shoults-Wilson, C.P. Starnes, G. Joice, D.A. Butterfield, and J.M. Unrine, “Short-Term Molecular-Level Effects of Silver Nanoparticle Exposure on the Earthworm, Eisenia Fetida,” Environmental Pollution 171, 249-255 (2012).
535. J.T. Keeney, A.M. Swomley, J.L. Harris, A. Fiorini, M.I. Mitov, M. Perluigi, R. Sultana, and D.A. Butterfield, “Cell Cycle Proteins in Brain in Mild Cognitive Impairment: Insights into Progression to Alzheimer’s Disease,” Neurotox. Res. 22, 220-230 (2012).
534. D.A. Butterfield, E. Barone, F. Di Domenico, G. Cenini, R. Sultana, M.P. Murphy, C. Mancuso, and E. Head, "Atorvastatin Treatment in a Dog Preclinical Model of Alzheimer Disease Leads to Up-regulation of Heme Oxygenase-1 and Is Associated with Reduced Oxidative Stress in Brain," Internat. J. Neuropsychopharmacol. 15, 981-987 (2012).
533. M.A. Erickson, P.E. Hartvigson, Y. Morofuji, J.B. Owen, D.A. Butterfield, and W.A. Banks. “Lipopolysaccharide Impairs Amyloid Beta Efflux From Brain: Altered Vascular Sequestration, Cerebrospinal Fluid Reabsorption, Peripheral Clearance and Transporter Function at the Blood-Brain Barrier,” J. Neuroinflammation 9, 150 (2012).
532. E. Barone, F. Di Domenico, R. Sultana, R. Coccia, C. Mancuso, M. Perluigi, and D.A. Butterfield, “Heme Oxygenase-1 Posttranslational Modifications in the Brain of Subjects with Alzheimer Disease and Mild Cognitive Impairment,” Free Radical Biology and Medicine 52, 2292–2301 (2012).
531. A.R. Evans, S. Miriyala, D.K. St. Clair, D.A. Butterfield, and R.A. Robinson, “Global Effects of Adriamycin Treatment on Mouse Splenic Protein Levels,” J. Proteome Res. 11, 1054-1064 (2012).
530. P. Jungsuwadee, T. Zhao, E.I. Stolarczyk, C.M. Paumi, D.A. Butterfield, D.K. St.Clair, and M. Vore, “The G671V Variant of MRP1/ABCC1 Links Doxorubicin-Induced Acute Cardiac Toxicity to Disposition of the Glutathione Conjugate of 4-Hydroxy-2-Trans-Nonenal,” Pharmacogenetics and Genomics Journal 22, 273-284 (2012).
529. E. Barone, G. Cenini, R. Sultana, F. Di Domenico, A. Fiorini, T. Noel, C. Mancuso, D.K. St. Clair, and D.A. Butterfield, “Lack of p53 Decreases Basal Oxidative Stress Levels in Brain Through Up-Regulation of Thioredoxin-1, Biliverdin Rederctase-A, Manganese Superoxide Dismutase, and Nuelear Factor-kapa B,” Antioxidants and Redox Signaling 16, 1407-1420 (2012).
528. R. Siciliano, E. Barone, V. Calabrese, V. Rispoli, D.A. Butterfield, and C. Mancuso, "Experimental Research On Nitric Oxide and the Therapy of Alzheimer Disease: A Challenging Bridge,” CNS Neurol Disord Drug Targets 10, 766-776 (2012).
527. F. De Marco, E. Bucaj, C. Foppoli, A. Fiorini, C. Blarzino, K. Filipi, A. Giorgi, M.E. Schininà, F. Di Domenico, R. Coccia, D.A. Butterfield, and M. Perluigi, “Oxidative Stress in HPV-Driven Viral Carcinogenesis: Redox Proteomics analysis of HPV-16 Dysplastic and Neoplastic Tissues,” Plos One 7, e34366 (2012).
526. M.T. Tseng, X. Lu, X. Duan, S.S. Hardas, R. Sultana, P. Wu, J.M. Unrine, U. Graham, D.A. Butterfield, E.A. Grulke, and R.A. Yokel, "Alteration of Hepatic Structure and Oxidative Stress Induced by Intravenous Nanoceria," Toxicology and Applied Pharmacology 260, 173-182 (2012).
525. R.A. Yokel, T.C. Au, R. MacPhail, S.S. Hardas, D.A. Butterfield, R. Sultana, M. Goodman, M.T. Tseng, M. Dan, A. Hughnazar, J.M. Unrine, U.M. Gram, P. Wn, and E.A. Grulhe, “Distribution, Elimination and Biopersistence to 90 Days of a Systemically-Introduced 30nm Ceria Engineered Nanomaterial in Rats,” Toxicological Sciences 127, 256-268 (2012).
524. F. Di Domenico, G. Casalena, J. Jia, R. Sultana, E. Barone, J. Cai, W.M. Pierce, C. Cini, M. Perluigi, C.M. Davis, N.J. Alkayed, and D.A. Butterfield, "Sex Differences in Brain Proteomes of Nuron-Specific Stat3-Null Mice after Cerebral Ischemia/Reperfusion," Journal of Neurochemistry 121, 680-692(2012).
523. G. Colombo, I. Dalle-Donne, M. Orioli, D. Giustarini, R. Rossi, M. Clerici; Luca Regazzoni, G. Aldini, A. Milzani, D.A. Butterfield, and N. Gagliano, “Oxidative Damage in Human Gingival Fibroblasts Exposed to Cigarette Smoke,” Free Radical Biology & Medicine 52, 1584-1596 (2012).
522. D.A. Butterfield and J.N. Keller, “Antioxidants and Antioxidant Treatment in Disease,” Biochim. Biophys. Acta – Molecular Basis of Disease 1822, 615 (2012).
521. C.B. Pocernich and D.A. Butterfield, "Elevation of Glutathione as a Therapeutic Strategy in Alzheimer Disease,” Biochim. Biophys. Acta – Molecular Basis of Disease 1822, 625-630 (2012).
520. L. Buizza, G. Cenini, C. Lanni, G. Ferrari-Toninelli, C. Prandelli, S. Govoni, E. Buoso, M. Racchi, M. Barcikowska, M. Styczynska, A. Szybinska, D.A. Butterfield, M. Memo, and D. Uberti, “Conformational Altered p53 as an Early Marker of Oxidative Stress in Alzheimer's Disease,” PLoS One 2012;7, e29789 (2012).
519. E. Barone, C. Mancuso, F. Di Domenico, R. Sultana, M.P. Murphy, E. Head, and D.A. Butterfield, “Biliverdin Reductase-A: a Novel Drug Target for Atorvastatin in a Dog Preclinical Model of Alzheimer Disease,” Journal of Neurochemistry 120, 135-146(2012).
518. M. Perluigi and D.A. Butterfield, "Oxidative Stress and Down Syndrome: a Route Toward Alzheimer-like Dementia," Current Gerontology and Geriatrics Research 2012:724904 (2012).
517. G. Cenini, A. Dowling, T. Beckett, E. Barone, C. Mancuso, M.P. Murphy, H. Levine, I. Lott, F. Schmitt, D.A. Butterfield, and E. Head, “Association Between Frontal Cortex Oxidative Damage and Beta-Amyloid as a Function of Age in Down Syndrome,” Biochim Biophys. Acta-Molec. Basis of Disease 1822, 130-138 (2012).
516. F. Di Domenico, R. Coccia, D.A. Butterfield, and M. Perluigi, “Circulating Biomarkers of Protein Oxidation for Alzheimer Disease: Expectations within Limits,” Biochim. Biophys. Acta- Proteins and Proteomics 1814, 1785-1795 (2011).
515. R.A.S. Robinson, G. Joshi, Q. Huang, R. Sultana, A.S. Baker, J. Cai, W.M. Pierce, D.K. St. Clair, W.R. Markesbery, and D.A. Butterfield, “Proteomics Analysis of Brain Proteins in APP/PS-1 Human Double Mutant Knock-in Mice with Increasing Amyloid β-Peptide Deposition: Insights into the Effects of in vivo Treatment with N-Acetylcysteine as a Potential Therapeutic Intervention in Mild Cognitive Impairment and Alzheimer Disease,”Proteomics 11, 4243-4256 (2011).
514. R.A.S. Robinson, M. Bader Lange, R.Sultana, V. Galvan, J. Fombonne, O. Gorostiza, J. Zhang, G. Warrier, J. Cai, W.M. Pierce,D.E. Bredesen, and D.A. Butterfield, “Differential Expression and Redox Proteomics Analyses of an Alzheimer Disease Transgenic Mouse Model: Effects of the Amyloid-β Peptide of Amyloid Precursor protein(=),” Neuroscience 177, 207-222 (2011).
513. R. Sultana, R.A.S. Robinson, H. Mohmmad Abdul, F. Di Domenico, D.K. St. Clair, W.R. Markesbery, J. Cai, W.M. Pierce, and D.A. Butterfield, "Proteomics Identification of Specifcally Carbonylated Brain Proteins in APPNLh/APPNLh X PS-1P264L/PS-1P264L Human Double Mutant Knock-in Mice Model of Alzheimer Disease as a Function of Age,” J. Proteomics 74, 2430-2440 (2011).
512. P.P. Wattamwar, S.S. Hardas, D.A. Butterfield, K.W. Anderson, and T.D. Dziubla, “Tuning of the Pro-Oxidant and Antioxidant Activity of Trolox Through the Controlled Release From Biodegradable Poly(Trolox Ester) Polymers,” Journal of Biomedical Materials Research, Part A 99, 184-191 (2011).
511. S.B. Martin, G. Cenini, E. Barone, A.L. Dowling, C. Mancuso, D.A. Butterfield, M.P. Murphy, and E. Head, "Coenzyme Q10 and Cognition in Atorvastin-treated Dogs," Neuroscience Letters 501, 92-95 (2011).
510. C. Mancuso, R. Siciliano, E. Barone, D.A. Butterfield, and P. Preziosi, “Pharmacologists and Alzheimer Disease Therapy: To Boldly Go Where No Scientist Has Gone Before,” Expert Opinion in Investigational Drugs 20, 1243-1261 (2011).
509. E. Barone, F. Di Domenico, G. Cenini, R. Sultana, R. Coccia, P. Preziosi, M. Perluigi, C. Mancuso, and D.A. Butterfield, “Oxidative and Nitrosative Modifications of Biliverdin Reductase in the Brain of Subjects with Alzheimer Disease and Mild Cognitive Impairment,”Journal of Alzheimer’s Disease 25, 623-633 (2011).
508. M. Perluigi and D.A. Butterfield, “The Identification of Protein Biomarkers for Oxidative Stress in Down Syndrome,” Expert Reviews of Proteomics 8, 427-429 (2011).
507. D.A. Butterfield, E. Barone, and C. Mancuso, “Cholesterol-Independent Neuroprotective and Neurotoxic Activities of Statins: Perspectives for Statin Use in Alzheimer Disease and Other Age-Related Neurodegenerative Disorders,” Pharmacological Research 64, 180-186 (2011).
506. D.A. Butterfield and R.Sultana, “Methionine-35 of Aβ (1–42): Importance for Oxidative Stress in Alzheimer Disease," Journal of Amino Acids 2011, 1-10 (2011).
505. F. Di Domenico, R. Sultana, E. Barone, M. Perluigi, C. Cini, C. Mancuso,J. Cai, W.M. Pierce, and D.A. Butterfield, “Quantitative Proteomics Analysis of Phosphorylated Proteins in the Hippocampus of Alzheimer's Disease Subjects,” Journal of Proteomics 74, 1091-1103 (2011).
504. C.B. Pocernich, M.L. Bader Lange, R. Sultana, and D.A. Butterfield, "Nutritional Approaches to Modulate Oxidative Stress in Alzheimer’s Disease," Current Alzheimer's Research 8, 452-469 (2011).
503. C.D. Aluise, S. Miriyala, T. Noel, R. Sultana, P. Jungsuwadee, T.J.Taylor, J. Cai, W.M. Pierce, M. Vore, J.A. Moscow, D.K. St. Clair, and D.A. Butterfield, “2-Mercaptoethanesulfonate (MESNA) Prevents Doxorubicin-Induced Plasma Protein Oxidation and TNFa Release,” Free Radical Biology & Medicine 50, 1630-1638 (2011).
502. M. Perluigi, F. Di Domenico, A. Fiorini, A. Cocciolo, A. Giorgi, C. Foppoli, D.A. Butterfield, M. Giorlandino, C. Giorlandino, M.E. Schinina, and R. Coccia, “Oxidative Stress Occurs Early in Down Syndrome Pregnancy: A Redox Proteomics Analysis of Amniotic Fluid,” Proteomics—Clinical Applications 167-178 (2011).
501. R. Sultana, P. Mecocci, F. Mangialasche, R. Cecchetti, and D.A. Butterfield, “Increased Protein and Lipid Oxidative Damage in Mitochondria Isolated From Lymphocytes From Patients with Alzheimer Disease: Insights into the Role of Oxidative Stress in Alzheimer's Disease and Initial Investigations into a Potential Biomarker for this Dementing Disorder,” Journal of Alzheimer's Disease 24, 77-84 (2011).
500. R. Sultana and D.A. Butterfield, “Brain Protein Oxidation and Modification for Good or for Bad in Alzheimer’s Disease,” Advances in Neurobiology 1, 585-605 (2011).
499. D.A. Butterfield, "Oxidative Stress in Alzheimer Disease: Synergy Between the Butterfield and Markesbery Laboratories," NeuroMolecular Medicine 13, 19-22 (2010.
498. D.A. Butterfield "Preface to the Special Issue of NeuroMolecular Medicine in Memory of the Life and Legacy of William R. Markesbery, M.D.," NeuroMolecular Medicine 13, 1-2 (2011).
497. D.A. Butterfield, T.T. Reed, and R. Sultana,"Roles of 3-Nitrotyrosine- and 4-Hydroxynonenal-Modified Brain Proteins in the Progression and Pathogenesis of Alzheimer's Disease," Free Radical Research 45, 59-72 (2011).
496. R. Sultana and D.A. Butterfield, “Identification of the Oxidative Stress Proteome in the Brain,” Free Radical Biology Medicine 50, 487-494 (2011).
495. D.A. Butterfield, “Atorvastatin and Aβ(1-40): Not as Simple as Cholesterol Reduction in Brain and Relevance to Alzheimer Disease,” Experimental Neurology 228, 15-18 (2011).
494. E. Barone, F. Di Domenico, G. Cenini, R. Sultana, C. Cini, P. Preziosi, M. Perluigi, C. Mancuso, and D.A. Butterfield, “Biliverdin Reductase-A Protein Levels and Activity in the Brains of Subjects with Alzheimer's Disease and Mild Cognitive Impairment,” Biochimica Biophysica Acta-Molecular Basis of Disease 1812, 480-487 (2011).
493. E. Barone, G. Cenini, F. Di Domenico, S. Martin, R. Sultana, C. Mancuso, M. Paul Murphy, E. Head, and D. Allan Butterfield, "Long-term High-dose Atorvastatin Decreases Brain Oxidative and Nitrosative Stress in a Preclinical Model of Alzheimer Disease: a Novel Mechanism of Action," Pharmacological Research 63, 172-180 (2011).
492. D.A. Butterfield and J.B. Owen, “Lectin-Affinity Chromatography Brain Glycoproteomics and Alzheimer Disease: Insights into Protein Alterations Consistent with the Pathology and Progression of this Dementing Disorder,” Proteomics—Clinical Applications 5, 50-56 (2011).
491. C.D. Aluise, R.A.S. Robinson, J. Cai, W.M. Pierce, W.R. Markesbery, and D.A. Butterfield, “Redox Proteomics Analysis of Brains From Subjects with Amnestic Mild Cognitive Impairment Compared to Brains From Subjects with Preclinical Alzheimer's Disease: Insights into Memory Loss in MCI,” Journal of Alzheimer’s Disease 23, 257-269 (2011).
490. F. Di Domenico, M. Perluigi, D.A. Butterfield, C. Cornelius, and V. Calabrese, “Oxidative Damage in Rat Brain During Aging: Interplay Between Energy and Metabolic Key Target Proteins,” Neurochem Res. 35, 2184-2192 (2010).
489. R.A. Sowell and D.A. Butterfield, “Spontaneous Vertebrate Models of Alzheimer Dementia: Selectively bred strains (SAM strains),” in Animal Models of Dementia, Neuromethods Series, Humana Press Inc.; New York, 271-293 (2010).
488. R. Sultana, F. Di Domenico, M. Tseng, J. Cai, T. Noel, R.L. Chelvarajan, W.D. Pierce, C. Cini, S. Bondada, D.K. St. Clair, and D.A. Butterfield, “Doxorubicin-Induced Thymus Senescence,” Journal of Proteome Research 9, 6232-6241(2010).
487. M. Perluigi, F. Di Domenico, A. Giorgi, M.E. Schininà, R. Coccia, C. Cini, F. Bellia, M.T. Cambria, C. Cornelius, D.A. Butterfield, and V. Calabrese, “Redox Proteomics in Aging Rat Brain: Involvement of Mitochondrial Reduced Glutathione Status and Mitochondrial Protein Oxidation in the Aging Process,” J. Neurosci. Res. 88, 3498-3507 (2010).
486. F. Di Domenico, J.B. Owen, R. Sultana, R.A. Sowell, M. Perluigi, C. Cini, J. Cai, W.M. Pierce, and D.A. Butterfield, “The Wheat Germ Agglutinin-Fractionated Proteome of Subjects with Alzheimer's Disease and Mild Cognitive Impairment Hippocampus and Inferior Parietal Lobule: Implications for Disease Pathogenesis and Progression,” J. Neurosci. Res. 88, 3566-3577 (2010).
485. F. Di Domenico, G. Casalena, R. Sultana, J. Cai, W.M Pierce, M. Perluigi, C. Cini, A. Baracca, G. Solaini, G. Lenaz, J. Jia, S.Dziennis, S.J. Murphy, N.J. Alkayed, and D.A. Butterfield, “Involvement of STAT3 in Mouse Brain Development and Sexual Dimorphism: A Proteomics Approach,” Brain Research 1362, 1-12 (2010).
484. R.E. Haskew-Laytona, J.B. Payappilly, N.A. Smirnova, T.C. Ma, K.K. Chan, T.H. Murphy, H. Guo, B. Langley, R. Sultana, D.A. Butterfield, S. Santagata, M.J. Alldred, I.G. Gazaryan, G.W. Bell, S.D. Ginsberg, and R.R. Ratan, “Controlled Enzymatic Production of Astrocytic Hydrogen Peroxide Protects Neurons From Oxidative Stress Via An Nrf2-Independent Pathway,” Proceedings of the National Academy of Sciences USA, 107, 17385-17390 (2010).
483. J.B. Owen, R. Sultana, C.D. Aluise, M.A. Erickson, T.O. Price, G. Bu, W.A. Banks, and D.A. Butterfield, “Oxidative Modification to LDL-related Receptor Protein 1 (LRP1) in Hippocampus From Subjects with Alzheimer's Disease: Implications for Aβ Accumulation in AD Brain,” Free Radical Biology and Medicine 49, 1798-1803 (2010).
482. G. Cenini, G. Maccarinelli, C. Lanni, S.A. Bonini, G. Ferrari-Toninelli, S. Govoni, M. Racchi, D.A. Butterfield, M. Memo, and D. Uberti, “Wild Type But Not Mutant APP is Involved in Protective Adaptive Responses Against Oxidants,” Amino Acids 39, 271-283 (2010).
481. J.B. Owen and D.A. Butterfield, "Measurement of Oxidized/Reduced Glutathione Ratio," Meth. Molec. Biol. 648, 269-277 (2010).
480. Q. Huang, C, Aluise, G. Joshi, R. Sultana, D. St. Clair, W. Markesbery, and D.A. Butterfield, "Potential In Vivo Amelioration By N-Acetyl-L-Cysteine of Oxidative Stress in Brain in Human Double Mutant APP/PS-1 Knock-In Mice: Towards Therapeutic Modulation of Mild Cognitive Impairment (MCI)," Journal of Neuroscience Research 88, 2618-2629 (2010).
479. S.S. Hardas, D.A. Butterfield, R. Sultana, M. Dan, R.L. Florence, J.M. Unrine, U.M. Graham, P. Wu, E.A. Grulke, M.T. Tseng, and R.A. Yokel, “Brain Distribution and Toxicological Evaluation of a Systemically Delivered Engineered Nanoscale Ceria,” Toxicological Sciences 116, 562-576 (2010).
478. D.A. Butterfield, M.L. Bader Lange, and R. Sultana, "Involvements of the Lipid Peroxidation Product, HNE, in the Pathogenesis and Progression of Alzheimer's Disease," Biochimica et Biophysica Acta 1801, 924-929 (2010).
477. C.D. Aluise, R. Sultana, J. Tangpong, M. Vore, D. St. Clair, J.A. Moscow, and D.A. Butterfield, "Chemo Brain (Chemo Fog) as a Potential Side Effect of Doxrubicin Administration: Role of Cytokine-induced, Oxidative/Nitrosative Stress in Cognitive Dysfunction," in Chemo-Fog (ed by R.B. Faffa and R.J. Tallarida), Landes Bioscience,Austin, TX pp 147-156 (2010).
476. C.D. Aluise, R.A.S. Robinson, T.L. Beckett, M.P. Murphy, J. Cai, W.M. Pierce, W.R. Markesbery, and D.A. Butterfield, Preclinical Alzheimer Disease: Brain Oxidative Stress, Aβ Peptide and Proteomics,” Neurobiology of Disease 39, 221-228 (2010).
475. D.A. Butterfield, S.S. Hardas, and M.L. Bader Lange, “Oxidatively Modified Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) and Alzheimer Disease: Many Pathways to Neurodegeneration,” Journal of Alzheimer’s Disease 20, 369-393 (2010).
474. M. Perluigi, F. Di Domenico, C. Blarzino, C. Foppoli, C. Cini, A. Giorgi, C. Grillo, F. De Marco, D.A. Butterfield, M.E. Schininna, and R. Coccia, “Effects of UVB-Induced Oxidative Stress on Protein Expression and Specific Protein Oxidation in Normal Human Epithelial Keratinocytes: A Proteomics Approach,” Proteome Science 8, 13-26 (2010).
473. F. Di Domenico, R. Sultana, G.F. Tiu, N.N. Scheff, M. Perluigi, C. Cini, and D.A. Butterfield, “Protein Levels of Heat Shock Proteins 27, 32, 60, 70, 90 and Thioredoxin-1 in Amnestic Mild Cognitive Impairment: An Investigation on the Role of Cellular Stress Response in the Progression of Alzheimer's Disease,” Brain Research 1333, 72-81 (2010).
472. D.A. Butterfield, "William R. Markesbery, M.D.: A Legacy of Excellence in Alzheimer's Disease Research and a Life Well Lived," Journal of Alzheimre's Disease 20, 3-4 (2010).
471. M.L. Lange, D.K. St. Clair, W.R. Markesbery, C.M. Studzinski, M.P. Murphy, and D.A. Butterfield, “Age-Related Loss of Phospholipid Asymmetry in APPNLh/APPNLh x PS-1P264L/PS-1P264L Human Double Mutant Knock-In Mice: Relevance to Alzheimer Disease,” Neurobiology of Disease 38, 104-115 (2010).
470. G. Joshi, C. D. Aluise, M.P. Cole, R. Sultana, M. Vore, D.K. St. Clair, and D.A. Butterfield, “Alterations in Brain Antioxidant Enzymes and Redox Proteomic Identification of Oxidized Brain Proteins Induced by the Anti-Cancer Drug Adriamycin: Implications for Oxidative Stress-Mediated Chemobrain,” Neuroscience 166, 796-807 (2010).
469. R. Sultana, M. Perluigi, S. Newman, W. Pierce, C. Cini, R. Coccia, and D.A. Butterfield, "Redox Proteomic Analysis of Carbonylated Brain Proteins in Mild Cognitive Impairment and Early Alzheimer's Disease," Antioxidants and Redox Signaling 12, 327-336 (2010).
468. Y.J. Suzuki, M. Carini, and D.A. Butterfield, “Protein Carbonylation,” Antioxidants and Redox Signaling 12, 323-325 (2010).
467. R. Sultana, W.A. Banks, and D.A. Butterfield, "Decreased Levels of PSD95 and Two Associated Proteins and Increased Levels of BCl2 and Caspase 3 in Hippocampus From Subjects with Amnestic Mild Cognitive Impairment: Insights into Their Potential Roles for Loss of Synapses and Memory, Accumulation of Aβ, and Neurodegeneration in a Prodromal Stage of Alzheimer’s Disease," Journal of Neuroscience Research 88, 469-477 (2010).
466. V. Calabrese, C. Cornelius, C. Mancuso, R. Lentile, A.M. Stella, and D.A. Butterfield, "Redox Homeostasis and Cellular Stress Response in Aging and Neurodegeneration," Meth. Molec. Biol. 610, 285-308 (2010).
465. D.A. Butterfield, V. Galvan, M. Bader Lange, H. Tang, R.A. Sowell, P. Spilman, J. Fombonne, O. Gorostiza, J. Zhang, R. Sultana, and D.E. Bredesen, "In Vivo Oxidative Stress in Brain of Alzheimer Disease Transgenic Mice: Requirement for Methionine 35 in Amyloid β-Peptide of APP," Free Radic Biol Med 48, 136-144 (2010).
464. T.T. Reed, R. Sultana, and D.A. Butterfield, “Redox Proteomics of Oxidatively Modified Brain Proteins in Mild Cognitive Impairment,” in Neuroproteomics (O. Alzate, Editor), Taylor and Francis Publishers, Boca Raton, FL, pp. 163-195 (2010).
463. R. Sultana and D.A. Butterfield<