Chemistry Event
Pursuing Cost-effective Solar Fuels through Artificial Photosynthesis
Catalent Info Session
Faculty-Student Coffee Hour
CANCELLED - 46th Annual Naff Symposium - Cannabinoids: Policy, Use and Safety
The Department of Chemistry at the University of Kentucky organizes an annual Symposium on Chemistry and Molecular Biology. This Symposium was established in honor of Anna S. Naff, a University of Kentucky graduate, through the generous support of Dr. Benton Naff of NIH. The Symposium has an interdisciplinary character and is attended by students and faculty from Chemistry, Biochemistry, Biology, Pharmacy, Engineering, Agriculture and Medicine. The Symposium features renowned experts from around the world, including Nobel prize-winning scientists and is attended by faculty and students from colleges and universities in Kentucky and the contiguous States.
The Symposium will be held in the William T. Young Library on the University of Kentucky campus. A poster session will be held in conjunction with the Symposium in the Jacobs Science Building.
Cannabinoids: Policy, Use and Safety |
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8:00am |
Registration & Continental Breakfast Gallery, W.T. Young Library |
8:50am | Welcome - TBD |
9:00am |
Mr. Andrew Freedman, Freedman & Koski, Inc. Making Medical Cannabis Medical Auditorium, W.T. Young Library |
10:00am | Coffee Break & Refreshments |
10:30am |
Dr. John Ingram, University of Mississippi Medical Center Cannabidiol (CBD) Cannabis Extract Oral Solution for Drug Resistant Pediatric Epilepsy Auditorium, W.T. Young Libary |
11:30am | Lunch Break |
1:30pm |
Dr. Chris Hudalla, ProVerde Laboratories Analytical Testing for the Hemp Industry: Monitoring Cultivation, Extraction and Processing Auditorium, W.T. Young Library |
2:30pm | Poster Session Set Up |
3:00pm | Poster Session |
Dr. John B. Ingram | |
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John (Brad) Ingram is an Associate Professor of Pediatrics and Director of the Pediatric Comprehensive Epilepsy Center at the University of Mississippi Medical Center, in Jackson, MS. He is also the Director of the Pediatric Neurophysiology Lab. In addition to his administrative positions, he is the Associate Program Director for both the Child Neurology and Clinical Neurophysiology programs, and is the Assistant Medical Student Clerkship Director for Pediatrics. He is also the Assistant Dean of GME for Faculty Development and Resident/Fellow Wellbeing. He is the PI for the Cannabidiol in Refractory Pediatric Epilepsy trial at UMMC, the first study of its kind. He has testified before the US Senate and been featured in the New York Times for issues related to Cannabis derived therapies in the US. Dr. Ingram is a member of the Child Neurology Society, the Professors of Child Neurology, the American Epilepsy Society, and is Secretary of the Southern Pediatric Neurology Society. He is a past Vice President of the Epilepsy Foundation of Mississippi and currently serves as the President of the Professional Advisory Committee for the Epilepsy Foundation of Mississippi. He is married and has three children. |
Cannabidiol (CBD) Cannabis Extract Oral Solution for Drug Resistant Pediatric Epilepsy |
Epilepsy can be defined as two or more isolated seizures which are not provoked by acute systemic or neurologic insults. Of the 2.3 million people in the United States with epilepsy, approximately one third are medically refractory. These statistics highlight the continuous need to identify novel molecules that are effective against epilepsy. Cannabidiol (CBD), due to its potent neurocognitive effects, has recently become a point of interest for neurological research, with a purified option already with FDA approval. We present the first US study aimed to understand the tolerability and efficacy of a novel high ratio cannabidiol/THC cannabis derived therapy in refractory pediatric epilepsy patients. Ten patients, ages 5-19 years, were administered escalating doses of a CBD compound in the first three months to achieve a final concentration of 7.5 mg/kg/day. Tolerability and efficacy were analyzed using the data from each patient’s EEGs, CBCs, CMPs, AED levels, seizure calendars and quality of life questionnaires. Results after 6 months of treatment showed a two-fold increase in desmethylclobazam levels in four patients. Additionally, eight of the ten patients reported improved attention and better overall health compared to their initial visits. Six out of ten patients reported decreased drowsiness compared to the initial visit. As for seizure control efficacy, seven out of ten patients reported a decrease in monthly seizures, five of which decreased by more than half since their first month of CBD. These results suggest that cannabidiol is a tolerable and potentially beneficial addition to an antiepileptic regimen for medially refractory epilepsy patients. |
Mr. Andrew Freedman |
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Andrew is a partner at Freedman & Koski, Inc, a consulting firm dedicated to helping governments and ancillary businesses successfully implement cannabis legalization. His firm has worked directly for 17 governments including California, Canada, Florida, Massachusetts, Maine, Rhode Island, Illinois state senate, and Mexico; and testified in front of almost all governments considering legalization. He has been a featured speaker at dozens of conferences including Code Conference, Summit, and Aspen Ideas Fest. Andrew brings vast experience from his three years as the State of Colorado’s first Director of Cannabis Coordination. During this time, he developed distinctive experience effectively implementing voter-mandated legalized adult-use and medical cannabis while protecting public health, maintaining public safety, and keeping cannabis out of the hands of children. |
Making Medical Cannabis Medical |
The medical cannabis movement broke all the rules. Now we need a few of them back. Andrew explores the extraordinary state-by-state creation of the medical cannabis regulatory system. He will touch on the history of the movement from a political and societal point of view before delving into current challenges and future possibilities —including what may happen when the USDA and FDA turn their attention this way. Andrew will focus on what he sees as the most important tension: Bringing scientific rigor to the medical cannabis industry while maintaining access to sympathetic patients. |
Dr. Christopher Hudalla | |
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Dr. Hudalla is a Ph.D. analytical chemist with more than 25 years of research experience in analytical chemistry, spectroscopy and chromatographic method development. He is recognized worldwide as an expert in the field of traditional Reverse Phase Liquid, Supercritical Fluid and Convergence Chromatography and an active leader in the development and implementation of the UltraPerformance Convergence Chromatography instrumentation. Dr. Hudalla is a founder and Chief Scientific Officer of ProVerde Laboratories, Inc., a premier analytical testing, CO2 extraction and derivative product formulation consultancy for the regulated medical cannabis and hemp industries. ProVerde is one of the first laboratories in the U.S. to receive an ISO 17025 accreditation that specifically governs hemp and medical cannabis testing. ProVerde Laboratories operates at the cutting edge of medical cannabis extraction, purification and product formulation techniques, supported by expert analytical testing, with expertise that will move research into cannabis and its effects on various medical conditions forward as the medical cannabis industry progresses. Dr. Hudalla plays an integral part in providing clients operating in the Medical Marijuana and hemp industries the ability to deliver new products and product formulations that meet the highest standards for quality, consistency, safety and labeling. Dr. Hudalla received his M.S. and Ph.D. from the University of California at Santa Barbara and was a Postdoctoral Fellow at the Eppley Institute for Cancer Research within the University of Nebraska Medical Center. Dr. Hudalla has delivered presentations all over the world in his areas of expertise, including analytical testing and research specific to medical cannabis and serves on the Cannabis Expert Panel with the United States Pharmacopeia (USP). |
Analytical Testing for the Hemp Industry: Monitoring Cultivation, Extraction and Processing |
The hemp industry is currently one of the fastest growing industries worldwide. In addition to the long history and use of hemp for fiber and fuel, this growth is fueled by recent revelations of the benefits of cannabinoid therapies for many health conditions. One challenge that has emerged is the ability to ensure consumer safety, providing accurate dosing and products that are free from potential contaminants. Analytical testing is a necessary component to ensure consumer safety for products that are being consumed both medicinally as well as recreationally. During production of hemp-based products, from cultivation, extraction and formulation, to finished consumer products, understanding and optimizing processes is a critical component to maximizing revenues. More importantly, there are many points at which contaminants can be introduced to the process, resulting in consumer products that are potentially hazardous for consumption or use. Because of these contaminants, many regulatory bodies are evaluating the need to monitor these contaminants and are currently crafting regulations to address these. The methodologies that will be used to meet these testing requirements include a wide variety of chromatographic techniques in addition to mass spectrometry and variety of approaches to address microbiological contaminants. Standardization of these methods for the industry will give regulators the resources they need to include sensible requirements for regulation and legislation that is being crafted to monitor and control the production of hemp-based products for human consumption. |
2020 Naff Committee Members:
Professor Bert Lynn (Chemistry, Committee Chair)
Professor Chris Richards (Chemistry)
For more information, contact Dr. Bert Lynn.
Dawson Lecture: New Synthetic Methods for C-F Bond Formation: From Fundamental Science to Applications
This presentation will describe our group's recent advances in developing metal-mediated/catalyzed methods for introducing fluorine into organic molecules. Our efforts into this area are guided by detailed fundamental studies of stoichiometric organometallic bond-forming reactions. These fundamental studies will be described in detail, and their translation to practical applications (particularly in the context of the synthesis of PET imaging agents) will be discussed.
Dr. Melanie Sanford
Melanie S. Sanford is currently the Moses Gomberg Distingished University Professor of Chemistry and Arthur F. Thurnau Professor of Chemistry at the University of Michigan, Ann Arbor. She received her B.S. and M.S. degrees at Yale University in 1996 where she carried out undergraduate research in the laboratory of Professor Robert Crabtree. She pursued graduate studies at the California Institute of Technology working with Professor Robert Grubbs. Following postdoctoral work at Princeton University with Professor John Groves, she joined the faculty at the University of Michigan in the summer of 2003 as an Assistant Professor of chemistry. She was promoted to associate professor in 2007, to full professor in 2010, to Arthur F. Thurnau Professor of Chemistry in 2011, and to Moses Gomberg Collegiate Professor of Chemistry in 2012. She has won a number of awards, including the ACS Award in Pure Chemistry, the Sackler Prize, the Blavatnik Award, and a MacArthur Foundation Fellowship. She is a member of the National Academy of Sciences and a Fellow of the ACS. Research in the Sanford group aims to develop new chemical reactions that enable the production of pharmaceuticals, agrochemicals, and fuels in a more efficient and environmentally friendly manner.
William N. Lipscomb Centennial Celebration
During the afternoon of October 24, 2019 the Chemistry Department will celebrate the 100th birthday (on December 9) of William Nunn Lipscomb, Jr., who is perhaps our most illustrious graduate. Lipscomb grew up in Lexington, graduated in 1941 from the University of Kentucky with a major in chemistry, and earned his Ph.D. from CalTech in 1946, where his mentor was Linus Pauling. After 13 years as a faculty member at the University of Minnesota Lipscomb was hired away in 1959 by Harvard University. In 1976 Lipscomb was awarded the Nobel Prize in Chemistry for his work on the structures and bonding of boranes, which are compounds composed of boron and hydrogen atoms. Later Lipscomb was equally well known for his pioneering studies of atomic-level structures of enzymes.
The celebration promises to be interesting and fun. There will be three speakers: Marjorie Wikler Senechal is a Lexington native who took piano lessons from Lipscomb’s sister and remained close to the family. She is Professor Emerita in Mathematics and History of Science and Technology at Smith College. The other two speakers earned their Ph.D. degrees at Harvard under Lipscomb’s direction. Irving R. Epstein, a professor at Brandeis University, will talk about Lipscomb's experimental and computational studies of boron compounds. Douglas C. Rees, a Lexington native who is now a professor at CalTech, will discuss Lipscomb’s biochemical work. All three will include anecdotes about Lipscomb, who was known to all as The Colonel, who made a YouTube video about how to tie a string tie (which had become his trademark), and who regularly found ways to slip amusing bits into his scientific papers.
The celebration, which will take place from 1-5 PM at the W. T. Young Library Auditorium, will be open to the public.
For a detailed schedule and information about the speakers, click here.
For information related to parking, please refer to the Transportation Services website at https://www.uky.edu/transportation/
Alumni Career Panel
Alyson Ackerman - Alyson Ackerman graduated from UK in May 2018 with a B.S. in Biochemistry. While at UK, Alyson participated in the professional chemistry fraternity, Alpha Chi Sigma, and conducted research with Dr. Lodder from the College of Pharmacy. Shortly after graduating, Alyson started working for Murty Pharmaceuticals. In her role as a QC chemist, Alyson tests raw materials, finished products, and performs various calibrations to ensure the lab equipment is qualified for use. She frequently works with HPLCs, UV-vis, FT-IR, and Laser Diffraction Particle Sizing.
Susan Griffith - J. Susan Griffith MD has been a College Health physician at U.K. since 1992. She is a Board-Certified Family Physician and previously worked in Urgent Care in Cincinnati OH and as a faculty member of the Department of Family Medicine at UK. She received her B.S. in Physical Anthropology in 1977 from UK and completed her MD in 1982 at UK. Her residency in Family Medicine was from 1982-85 at UK and she was the Chief Resident from 1984-85. Dr. Griffith enjoyed her time in the Chemistry-Physics building, taking 20 hours of Chemistry courses and 10 hours of Physics courses as part of the Pre-Med requirements. It was also an interesting experience for her to have her father as a teacher. Her dad, Charles H.H. Griffith, was the Lab Supervisor for Chem-115 from 1964-1993. At University Health Service at UK, she does all the minor surgical procedures in addition to regular medical care for UK students and employees. Her volunteer work includes being the Research Chair for the International Council of Multiple Birth Organization and the Research Interpreter for Multiples of America. Dr. Griffith adds , “As part of the eulogy I gave for my dad, I told everyone how much my dad loved Chemistry and how much he loved teaching the students of the University of Kentucky. I want to honor his memory by doing whatever I can to help the UK Chemistry Department continue to be a strong scientific department that cares about the students of UK.”
Jeffrey R. Lomprey - Dr. Jeff Lomprey is a partner and intellectual property lawyer with Foley & Lardner LLP where his practice focuses on patent preparation, both U.S. and foreign prosecution, counseling, due diligence, and litigation support. He is a member of the firm’s Chemical, Biotechnology & Pharmaceutical Practice as well as the Life Sciences Industry Team. Jeff’s interests span a diverse array of chemical and mechanical technologies. He has significant experience in the areas of small molecule chemistry, pharmaceuticals, batteries, catalysts, polymers, electrochemistry, organic light emitting diodes, mechanical devices, and medical devices. Prior to joining Foley, Jeff was a senior research chemist at Gentex Corporation from 1997-2002, where he was involved in the development and production of automatically dimming automobile mirrors. Jeff earned his Juris Doctorate from the University of Wisconsin Law School (cum laude, 2005), where he was a member of the Dean’s list. He earned his Ph.D. in chemistry from the University of Kentucky (1993), and was the recipient of the Outstanding Graduate Student Researcher Award. He earned his Bachelor of Science degree in chemistry from the University of Wisconsin – Stevens Point (1988). Dr. Lomprey is admitted to practice in Wisconsin and before the United States Patent and Trademark Office. He is a member the Wisconsin and American Bar Associations, the American Chemical Society and the American Intellectual Property Law Association.
Tanea Reed - Dr. Reed received her PhD in biological chemistry from the University of Kentucky and worked under the guidance of Dr. D. Allan Butterfield. While at UK, she received the Lyman T. Johnson Minority Fellowship and the UK Woman’s Club Endowed Fellowship. She received her Bachelor of Science degree in Biochemistry from Virginia Polytechnic Institute and State University. In 2010, Dr. Reed received the Hermann Esterbauer award in Turin, Italy for her work on lipid peroxidation in Alzheimer’s disease. She is currently a member of the international selection committee for this award. Dr. Reed is currently an associate professor of biochemistry at Eastern Kentucky University, where she serves as a research mentor for undergraduate and graduate students. She was recently awarded an area enrichment award from the National Institutes of Health for her research which focuses on post injury treatments for moderate traumatic brain injury.
Vince Stapp - Vince earned his BS in Chemistry from the University of Kentucky in 1991, and received the Undergraduate Service Award with focused interests in Mass Spectrometry and Separation Science. During his time as an undergraduate, he was a freshman chemistry lab teaching assistant and he conducted his undergraduate research with Dr. John Patterson on new synthesis routes for n-substituted pyrroles. Vince spent one year as a staff scientist at PTRL, Inc. in Richmond, KY developing quantitative GC/MS methods for environmental fate studies of pesticides and herbicides. He then began his career at Procter & Gamble in 1992, and has worked as an analytical chemist and technical leader in several different P&G business units including Skin/Beauty Care, Corporate Research Division Mass Spectrometry group, and Upstream Paper Technology. His focus during this time was developing MS(n), accurate mass, GC/MS, and LC/MS methods for structure elucidation and quantitative analysis, and worked in close partnership with P&G technologists on biodegradable polymer feedstocks (Nodax), bleach catalysts, phospholipids (Olestra), and adhesives. Vince has a broad background in material science, volatiles analysis and olfaction, mass spectrometry, separation science, and complex technical problem solving. His last 17 years has been in the Baby Care business as a Senior Scientist where he has been an analytical leader for the polymer films and nonwovens material development area. Vince’s passion is people development. He is active as a technical and career mentor both inside and outside of P&G.
Graduation Celebration & Student Awards Ceremony
The Department of Chemistry hosts an annual Graduation Celebration and Awards Ceremony to recognize the outstanding acheivements of our students on an annual basis. This year we would like to recognize the following graduates of our PhD, Masters, and Undergraduate programs:
Doctor of Philosophy
Wenjin Cao
Kai Ding
Alexis Eugene
Zhen Fang
John Hoben
Daniel Kirchhoff
Ryan Loe
Faruk Moonschi
Anthony Petty
Daudi Saang'onyo
Yang (Vanessa) Song
Laura Walther
Zhihui Zhang
Master of Science
Hope Cook Abdalla
Amber Bowman
Andrew (AJ) Bradley
Nandini Gundaram Suresh
Edward (Kirkbride) Loya
Xiao Tan
Bachelor of Arts
Annie Jo Baker
Morgan Louis Blair *
Kevin Russel Eversole
Kevin P Kelley, II
Musab Mohammad Shalash
Eashwar Vellaiappan Somasundaram *
Bachelor of Science
Tanner Wetzel Adams
Eve Deva Aldridge
Melissa Lynn Becker
Joshua Michael Betts
Jamie Elizabeth Boggs
Kyle T Brutscher
Haley Whitney Carroll
Katherine Rose Clowes *
Keisten T Collins
Cassadi Jordan Cordea *
John Gregory Davis
Mike Alfred Dittert
Lilly Do
Matthew Brady Ekman *
Logan John Eslinger *
William Eubanks, III
Madison Paige Ginn *
Heba Rasheed Hanbali
David Andrew Harris *
Sarah Elise Hodges
Sirui Huang
William C Jennings *
Sarah E Johnson
Morgan L Keyser
Brenna Kirkpatrick
John Klein *
Katherine Anne Kloska
Alysia Joy Kohlbrand
Don Edward Laird
Allison Carol Lane
Lyric Jasmine Lane
Harrison Evans Lee
Zi En Lee
Jumanah Mahmoud *
Gregory Nathaniel Milburn *
Jonathan Steele Nelson
Sara Ann Novotny
Jacquelyn Estes Rhinehart *
Antonela Rodriguez
Chia-Hsuan (Jessica) Shen *
Olivia Marie Tholt *
Caroline Elizabeth Thornbury
Matthew Thomas Wasmund
Liying Wu *
*Denotes Chemistry Department Honors