Chris Richards

ciri222's picture
  • Associate Professor
  • Analytical
  • Biological
  • Chemistry
  • Physical
209 Chemistry-Physics Building
Research Interests:
Education

Ph.D. Georgia Institute of Technology 2005-2009
Postdoctoral Fellow California Institute of Technology 2009-2012

Biography

We are an interdisciplinary group that integrates nanotechnology, neuroscience, and biophysics.

For more information, please visit the Richards Group website.

Research

We are an interdisciplinary group that integrates nanotechnology, neuroscience, and biophysical chemistry.  A major component of our research is the development of single-molecule fluorescence imaging techniques that allow us to isolate individual membrane receptors. These studies primarily focus on the interaction of fluorophores with plasmonic metal structures to enhance the emission from fluorescently labeled proteins.  We use these techniques to understand how modifications in membrane receptor trafficking and assembly alters neuronal function and is involved in the mechanisms of neurodegenerative diseases and addiction.

Graduate Training

Biophysical Chemistry Neuroscience

PubMed Publications*: 
  • Chen, J.;Wang, S.;Zhang, Z.;Richards, CI ;Xu, R "Heat shock protein 47 (HSP47) binds to discoidin domain-containing receptor 2 (DDR2) and regulates its protein stability." The Journal of biological chemistry (2019): Details. Full text
  • Snell, AA ;Neupane, KR ;Fu, X ;Moonschi, FH ;Caudill, EB ;Kolesar, J ;Richards, CI "Cell-Derived Vesicles for in Vitro and in Vivo Targeted Therapeutic Delivery." ACS omega 4, 7 (2019): 12657-12664. Details.
  • Fu, X ;Moonschi, FH ;Fox-Loe, AM ;Snell, AA ;Hopkins, DM ;Avelar, AJ ;Henderson, BJ ;Pauly, JR ;Richards, CI "Brain Region Specific Single-Molecule Fluorescence Imaging." Analytical chemistry 91, 15 (2019): 10125-10131. Details. Full text
  • Moonschi, FH ;Fox-Loe, AM ;Fu, X ;Richards, CI "Mammalian Cell-derived Vesicles for the Isolation of Organelle Specific Transmembrane Proteins to Conduct Single Molecule Studies." Bio-protocol 8, 9 (2018): Details.
  • Moonschi, FH ;Hughes, CB ;Mussman, GM ;Fowlkes, JL ;Richards, CI ;Popescu, I "Advances in micro- and nanotechnologies for the GLP-1-based therapy and imaging of pancreatic beta-cells." Acta diabetologica 55, 5 (2018): 405-418. Details. Full text
  • Fox-Loe, AM ;Moonschi, FH ;Richards, CI "Organelle-specific single-molecule imaging of α4β2 nicotinic receptors reveals the effect of nicotine on receptor assembly and cell-surface trafficking." The Journal of biological chemistry 292, 51 (2017): 21159-21169. Details. Full text
  • Martin, WE ;Ge, N ;Srijanto, BR ;Furnish, E ;Collier, CP ;Trinkle, CA ;Richards, CI "Real-Time Sensing of Single-Ligand Delivery with Nanoaperture-Integrated Microfluidic Devices." ACS omega 2, 7 (2017): 3858-3867. Details. Full text
  • Fox-Loe, AM ;Henderson, BJ ;Richards, CI "Utilizing pHluorin-tagged Receptors to Monitor Subcellular Localization and Trafficking." Journal of visualized experiments : JoVE 121 (2017): Details. Full text
  • Zhang, Z.;Baksh, MM ;Finn, MG ;Heidary, DK ;Richards, CI "Direct Measurement of Trafficking of the Cystic Fibrosis Transmembrane Conductance Regulator to the Cell Surface and Binding to a Chemical Chaperone." Biochemistry 56, 1 (2017): 240-249. Details. Full text
  • Martin, WE ;Srijanto, BR ;Collier, CP ;Vosch, T ;Richards, CI "A Comparison of Single-Molecule Emission in Aluminum and Gold Zero-Mode Waveguides." The journal of physical chemistry. A 120, 34 (2016): 6719-27. Details. Full text
  • Fox, AM ;Moonschi, FH ;Richards, CI "The nicotine metabolite, cotinine, alters the assembly and trafficking of a subset of nicotinic acetylcholine receptors." The Journal of biological chemistry 290, 40 (2015): 24403-12. Details. Full text
  • Wieskopf, JS ;Mathur, J ;Limapichat, W ;Post, MR ;Al-Qazzaz, M ;Sorge, RE ;Martin, LJ ;Zaykin, DV ;Smith, SB ;Freitas, K ;Austin, JS ;Dai, F ;Zhang, J.;Marcovitz, J ;Tuttle, AH ;Slepian, PM ;Clarke, S ;Drenan, RM ;Janes, J ;Sharari, Al ;Segall, SK ;Aasvang, EK ;Lai, W ;Bittner, R ;Richards, CI ;Slade, GD ;Kehlet, H ;Walker, J.;Maskos, U ;Changeux, JP ;Devor, M ;Maixner, W ;Diatchenko, L ;Belfer, I ;Dougherty, DA ;Su, AI ;Lummis, SC ;Damaj, Imad ;Lester, HA ;Patapoutian, A ;Mogil, JS "The nicotinic α6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptors." Science translational medicine 7, 287 (2015): 287ra72. Details. Full text
  • Nichols, WA ;Henderson, BJ ;Yu, C ;Parker, RL ;Richards, CI ;Lester, HA ;Miwa, JM "Lynx1 shifts α4β2 nicotinic receptor subunit stoichiometry by affecting assembly in the endoplasmic reticulum." The Journal of biological chemistry 289, 45 (2014): 31423-32. Details. Full text
  • Srinivasan, R ;Henderson, BJ ;Lester, HA ;Richards, CI "Pharmacological chaperoning of nAChRs: a therapeutic target for Parkinson's disease." Pharmacological research 83, (2014): 20-9. Details. Full text
  • Zhang, Z.;Heidary, DK ;Richards, CI "High resolution measurement of membrane receptor endocytosis." Journal of biological methods 5, 4 (0): e105. Details.
* Publications are automatically pulled from pubmed.gov based on a user-specific query. Results may include incorrect citations. See: Tutorial on improving PubMed results.
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