We are an interdisciplinary group that integrates nanotechnology, neuroscience, and biophysical chemistry. A major component of our research is the development of single-molecule fluorescence imaging techniques that allow us to isolate individual membrane receptors. These studies primarily focus on the interaction of fluorophores with plasmonic metal structures to enhance the emission from fluorescently labeled proteins. We use these techniques to understand how modifications in membrane receptor trafficking and assembly alters neuronal function and is involved in the mechanisms of neurodegenerative diseases and addiction.
Biophysical Chemistry Neuroscience