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Chemistry Department Seminar

Graduation Celebration

Celebration banner

The Department of Chemistry hosts an annual Graduation Celebration and Awards Ceremony to recognize the outstanding achievements of our students on an annual basis.

We invite families and friends of graduates and award winners to join us in celebrating the success of these outstanding students. A reception will be held after the ceremony. 

To view this year's brochure, click here. For past events, click here.

11:00am - 12:00pm Recognition of graduating class of 2025
12:00pm - 2:30pm Outdoor picnic in Alumni Commons

College of Arts and Sciences Awards

Outstanding Teaching Assistant in the Department of Chemistry | Shuvo Deb Nath

Graduate Student Awards

100% Plus Award | Lateefat Jimoh

Outstanding Graduate Student Research Award | Kathryn Pitton

Outstanding Teaching Assistant Award | Md Tawabur Rahman & Motunrayo Oladele

William D. Ehmann Graduate Award Fund in Chemistry | Shickshitha Dissanayake

C.H.H. Griffith Outstanding General Chemistry TA Award | Deborah Adeyemi-Alabi & Alexander Igwebuike

Fast Start Award | Joy Jerome

Undergraduate Student Awards

100% Plus Award | Lauren Gravatte

Hammond Undergraduate Service Award | Walter Kunnmann

Hammond Leadership Award | Shasanka Lamichhane

Nancy J. Stafford Award | Mason Marrs

Willard R. Meredith Memorial Award | Marissa Harris

First-Year Chemistry Major Award | Isabella Soon

General Chemistry Excellence Award (Spring 2024) | Thomas Lockhart, Elizabeth Scheetz & Caralea Vest

General Chemistry Excellence Award (Fall 2024) | Harsh Patel & Lauren Marksbury

Undergraduate Scholarships

Wilbur L. Price Scholarship | Daani Karim

Date:
Location:
JSB 321

Graduation Celebration

Celebration banner

The Department of Chemistry hosts an annual Graduation Celebration and Awards Ceremony to recognize the outstanding achievements of our students on an annual basis.

We invite families and friends of graduates and award winners to join us in celebrating the success of these outstanding students. A reception will be held after the ceremony. 

To view this year's brochure, click here. For past events, click here.

11:00am - 12:00pm Recognition of graduating class of 2025
12:00pm - 2:30pm Outdoor picnic in Alumni Commons

College of Arts and Sciences Awards

Outstanding Teaching Assistant in the Department of Chemistry | Shuvo Deb Nath

Graduate Student Awards

100% Plus Award | Lateefat Jimoh

Outstanding Graduate Student Research Award | Kathryn Pitton

Outstanding Teaching Assistant Award | Md Tawabur Rahman & Motunrayo Oladele

William D. Ehmann Graduate Award Fund in Chemistry | Shickshitha Dissanayake

C.H.H. Griffith Outstanding General Chemistry TA Award | Deborah Adeyemi-Alabi & Alexander Igwebuike

Fast Start Award | Joy Jerome

Undergraduate Student Awards

100% Plus Award | Lauren Gravatte

Hammond Undergraduate Service Award | Walter Kunnmann

Hammond Leadership Award | Shasanka Lamichhane

Nancy J. Stafford Award | Mason Marrs

Willard R. Meredith Memorial Award | Marissa Harris

First-Year Chemistry Major Award | Isabella Soon

General Chemistry Excellence Award (Spring 2024) | Thomas Lockhart, Elizabeth Scheetz & Caralea Vest

General Chemistry Excellence Award (Fall 2024) | Harsh Patel & Lauren Marksbury

Undergraduate Scholarships

Wilbur L. Price Scholarship | Daani Karim

Date:
Location:
JSB 321

Graduation Celebration

Celebration banner

The Department of Chemistry hosts an annual Graduation Celebration and Awards Ceremony to recognize the outstanding achievements of our students on an annual basis.

We invite families and friends of graduates and award winners to join us in celebrating the success of these outstanding students. A reception will be held after the ceremony. 

To view this year's brochure, click here. For past events, click here.

11:00am - 12:00pm Recognition of graduating class of 2025
12:00pm - 2:30pm Outdoor picnic in Alumni Commons

College of Arts and Sciences Awards

Outstanding Teaching Assistant in the Department of Chemistry | Shuvo Deb Nath

Graduate Student Awards

100% Plus Award | Lateefat Jimoh

Outstanding Graduate Student Research Award | Kathryn Pitton

Outstanding Teaching Assistant Award | Md Tawabur Rahman & Motunrayo Oladele

William D. Ehmann Graduate Award Fund in Chemistry | Shickshitha Dissanayake

C.H.H. Griffith Outstanding General Chemistry TA Award | Deborah Adeyemi-Alabi & Alexander Igwebuike

Fast Start Award | Joy Jerome

Undergraduate Student Awards

100% Plus Award | Lauren Gravatte

Hammond Undergraduate Service Award | Walter Kunnmann

Hammond Leadership Award | Shasanka Lamichhane

Nancy J. Stafford Award | Mason Marrs

Willard R. Meredith Memorial Award | Marissa Harris

First-Year Chemistry Major Award | Isabella Soon

General Chemistry Excellence Award (Spring 2024) | Thomas Lockhart, Elizabeth Scheetz & Caralea Vest

General Chemistry Excellence Award (Fall 2024) | Harsh Patel & Lauren Marksbury

Undergraduate Scholarships

Wilbur L. Price Scholarship | Daani Karim

Date:
Location:
JSB 321

Graduation Celebration

Celebration banner

The Department of Chemistry hosts an annual Graduation Celebration and Awards Ceremony to recognize the outstanding achievements of our students on an annual basis.

We invite families and friends of graduates and award winners to join us in celebrating the success of these outstanding students. A reception will be held after the ceremony. 

To view this year's brochure, click here. For past events, click here.

11:00am - 12:00pm Recognition of graduating class of 2025
12:00pm - 2:30pm Outdoor picnic in Alumni Commons

College of Arts and Sciences Awards

Outstanding Teaching Assistant in the Department of Chemistry | Shuvo Deb Nath

Graduate Student Awards

100% Plus Award | Lateefat Jimoh

Outstanding Graduate Student Research Award | Kathryn Pitton

Outstanding Teaching Assistant Award | Md Tawabur Rahman & Motunrayo Oladele

William D. Ehmann Graduate Award Fund in Chemistry | Shickshitha Dissanayake

C.H.H. Griffith Outstanding General Chemistry TA Award | Deborah Adeyemi-Alabi & Alexander Igwebuike

Fast Start Award | Joy Jerome

Undergraduate Student Awards

100% Plus Award | Lauren Gravatte

Hammond Undergraduate Service Award | Walter Kunnmann

Hammond Leadership Award | Shasanka Lamichhane

Nancy J. Stafford Award | Mason Marrs

Willard R. Meredith Memorial Award | Marissa Harris

First-Year Chemistry Major Award | Isabella Soon

General Chemistry Excellence Award (Spring 2024) | Thomas Lockhart, Elizabeth Scheetz & Caralea Vest

General Chemistry Excellence Award (Fall 2024) | Harsh Patel & Lauren Marksbury

Undergraduate Scholarships

Wilbur L. Price Scholarship | Daani Karim

Date:
Location:
JSB 321

Exit seminar: Developing Synthetic Strategies for Three-Coordinate Gold(I) Complexes as Anticancer Agents

headshotGold(I) complexes typically bond in a linear fashion; however, an increased valence can be achieved via ligand modulation. The most prevalent therapeutic gold complex, auranofin, contains a linear Au(I) center and has shown great potential in several diseases and conditions. On the other hand, the potential of three-coordinate Au(I) complexes have scarcely been probed as therapeutics. Reported here are the synthesis, characterization, and applications of novel three-coordinate Au(I) complexes. The degree of asymmetry varies between complexes depending on the Au-X ancillary ligands. This insight suggests that the degree of asymmetry influences the potency when incubated in various cancer cell lines. In addition, the coordination of bidentate phenanthroline ligand derivatives effect the symmetry by inducing varying degrees of distortion in the crystal structure. When the center Au(I) is bound to an N-Heterocyclic Carbene (NHC), the compound shifts from a distorted trigonal planar geometry to a distorted linear geometry. These complexes were used to probe glioblastoma, an aggressive head-and-neck cancer. When the center Au(I) is bound to biaryl dialkyl phosphine ligands, the geometry varies in symmetry, but the distorted trigonal planar geometry remains intact. Structure activity relationship studies were performed on these complexes in triple negative breast cancer cell lines. Previous research shows a disruption of mitochondrial dynamics when cancer cells were treated with three-coordinate Au(I) complexes, and the novel Au(I)-NHC library indeed disrupts mitochondrial dynamics. Mitochondria are the main energy production centers in the cell and are desirable therapeutic targets due to their implication in aging, inflammation, and cancer. The Au(I)-P library shows little mitochondrial disruption; instead, these complexes induce significant stress in the endoplasmic reticulum. The endoplasmic reticulum transports and folds proteins that allow the cell to function properly and synthesizes lipids and cholesterols. When the endoplasmic reticulum undergoes stress, the several signaling pathways, known as the unfolded protein response, activate, which can lead to lipid accumulation. Both a disruption of mitochondrial dynamics and an induction of endoplasmic reticulum stress can lead to apoptotic cell death. These effects were characterized by several in vitro and in vivo experiments. 

1

Carboranes are electron-delocalized clusters containing as few as five and as many as fourteen boron and carbon atoms, the majority of which contain two cage carbons. The carbons in the cluster can be easily functionalized with alkyl and aryl phosphines for coordination to metal complexes. Described here is the synthesis of phosphine-functionalized carborane (DPPCb) containing three-coordinate Au(I) complexes. Taken as a whole, this work expands on the current three-coordinate gold(I) libraries and evaluates their in vitro and in vivo biological efficacy.

Date:
Location:
CP 114

Exit seminar: Developing Synthetic Strategies for Three-Coordinate Gold(I) Complexes as Anticancer Agents

headshotGold(I) complexes typically bond in a linear fashion; however, an increased valence can be achieved via ligand modulation. The most prevalent therapeutic gold complex, auranofin, contains a linear Au(I) center and has shown great potential in several diseases and conditions. On the other hand, the potential of three-coordinate Au(I) complexes have scarcely been probed as therapeutics. Reported here are the synthesis, characterization, and applications of novel three-coordinate Au(I) complexes. The degree of asymmetry varies between complexes depending on the Au-X ancillary ligands. This insight suggests that the degree of asymmetry influences the potency when incubated in various cancer cell lines. In addition, the coordination of bidentate phenanthroline ligand derivatives effect the symmetry by inducing varying degrees of distortion in the crystal structure. When the center Au(I) is bound to an N-Heterocyclic Carbene (NHC), the compound shifts from a distorted trigonal planar geometry to a distorted linear geometry. These complexes were used to probe glioblastoma, an aggressive head-and-neck cancer. When the center Au(I) is bound to biaryl dialkyl phosphine ligands, the geometry varies in symmetry, but the distorted trigonal planar geometry remains intact. Structure activity relationship studies were performed on these complexes in triple negative breast cancer cell lines. Previous research shows a disruption of mitochondrial dynamics when cancer cells were treated with three-coordinate Au(I) complexes, and the novel Au(I)-NHC library indeed disrupts mitochondrial dynamics. Mitochondria are the main energy production centers in the cell and are desirable therapeutic targets due to their implication in aging, inflammation, and cancer. The Au(I)-P library shows little mitochondrial disruption; instead, these complexes induce significant stress in the endoplasmic reticulum. The endoplasmic reticulum transports and folds proteins that allow the cell to function properly and synthesizes lipids and cholesterols. When the endoplasmic reticulum undergoes stress, the several signaling pathways, known as the unfolded protein response, activate, which can lead to lipid accumulation. Both a disruption of mitochondrial dynamics and an induction of endoplasmic reticulum stress can lead to apoptotic cell death. These effects were characterized by several in vitro and in vivo experiments. 

1

Carboranes are electron-delocalized clusters containing as few as five and as many as fourteen boron and carbon atoms, the majority of which contain two cage carbons. The carbons in the cluster can be easily functionalized with alkyl and aryl phosphines for coordination to metal complexes. Described here is the synthesis of phosphine-functionalized carborane (DPPCb) containing three-coordinate Au(I) complexes. Taken as a whole, this work expands on the current three-coordinate gold(I) libraries and evaluates their in vitro and in vivo biological efficacy.

Date:
Location:
CP 114

Exit seminar: Effects of A-Site Cation Structure on Optical and Electronic Properties of 2D Ruddlesden-Popper Phase Tin-Based Hybrid Perovskites

2

 

Organic metal halide perovskites (HPs) are attractive materials for a variety of electronic applications due to their low cost, tunable band gaps, excellent charge transport properties, and high photoluminescence efficiency. As such, HPs are being investigated for use in solar cells, photodetectors, X-ray detectors, light emitting diodes, field effect transistors, lasers, resistive random-access memory, etc. Currently the most popular metal used in HPs is lead, but the use of lead comes with the potential for heavy metal exposure. Tin-based perovskites offer a less hazardous alternative, but their optoelectronic properties lag behind those of lead and less work has been done to characterize them. In this work, we investigate Ruddlesden-Popper Phase (RPP) tin perovskites with phenethylammonium and its derivatives to determine how the structure of the A*-site cation impacts the optical and electronic properties.

 

 

1

 

Date:
Location:
CP 114

Exit seminar: Effects of A-Site Cation Structure on Optical and Electronic Properties of 2D Ruddlesden-Popper Phase Tin-Based Hybrid Perovskites

2

 

Organic metal halide perovskites (HPs) are attractive materials for a variety of electronic applications due to their low cost, tunable band gaps, excellent charge transport properties, and high photoluminescence efficiency. As such, HPs are being investigated for use in solar cells, photodetectors, X-ray detectors, light emitting diodes, field effect transistors, lasers, resistive random-access memory, etc. Currently the most popular metal used in HPs is lead, but the use of lead comes with the potential for heavy metal exposure. Tin-based perovskites offer a less hazardous alternative, but their optoelectronic properties lag behind those of lead and less work has been done to characterize them. In this work, we investigate Ruddlesden-Popper Phase (RPP) tin perovskites with phenethylammonium and its derivatives to determine how the structure of the A*-site cation impacts the optical and electronic properties.

 

 

1

 

Date:
Location:
CP 114

Exit seminar: Insights into Factors Influencing Radical Chemistry of Monolignols during Lignification and Induced Changes in Plant Secondary Metabolism

HeadshotLignin is a complex aromatic biopolymer and an important constituent in plant cell walls. The process of lignin biosynthesis, known as lignification, is poorly understood and challenging to study but has important implications in a variety of fields including sustainable energy, bioengineering, and materials science and is therefore of interest to pursue. In the final stage of lignification, H-, G-, and S-monolignols are oxidized by laccase and peroxidase enzymes to generate radical species that couple to form dimers and further oligomeric species to ultimately produce the lignin polymer. Biomimetic lignin model systems utilize in vitro oxidative coupling reactions as an important tool to further develop our understanding of this complex process. The goal of the first portion of this dissertation was to explore several aspects of monolignol oxidative coupling using high performance liquid chromatography (HPLC). These aspects included the study of relative reaction rates, both with respect to monolignol conversion and product formation, and the effects of solvent composition on product distribution. Electrospray ionization mass spectrometry (ESI-MS) was an important analytical tool for characterizing many coupling products, especially higher oligomeric compounds. The insights acquired from these experiments contributed valuable information towards a fuller understanding of the lignification process.

Graphic 1

Plant secondary metabolites are a vital source of medicinally relevant compounds. These metabolites are involved in the plants’ highly dynamic chemical defense against environmental stressors such as UV light, predators, and pathogens. Elicitation is a process in which changes in plant secondary metabolism are induced by specific stressors to understand metabolic pathways involved in plant defense. The second portion of this dissertation focused on the study of metabolism, known as metabolomics. Methods development for sample preparation and data processing in untargeted metabolomics was applied to study elicitation of secondary metabolites in Lobelia Cardinalis hairy root cultures. This study specifically explored the potential of nanoparticles as a delivery system to enhance the elicitation effects of jasmonic acid. In this work, UHPLC-MS with high resolution accurate mass was used to evaluate the secondary metabolic response of L. Cardinalis hairy root cultures to jasmonic acid-loaded nanoparticles.

Graphic 2Graphic 3

Date:
Location:
CP 114

Exit seminar: Insights into Factors Influencing Radical Chemistry of Monolignols during Lignification and Induced Changes in Plant Secondary Metabolism

HeadshotLignin is a complex aromatic biopolymer and an important constituent in plant cell walls. The process of lignin biosynthesis, known as lignification, is poorly understood and challenging to study but has important implications in a variety of fields including sustainable energy, bioengineering, and materials science and is therefore of interest to pursue. In the final stage of lignification, H-, G-, and S-monolignols are oxidized by laccase and peroxidase enzymes to generate radical species that couple to form dimers and further oligomeric species to ultimately produce the lignin polymer. Biomimetic lignin model systems utilize in vitro oxidative coupling reactions as an important tool to further develop our understanding of this complex process. The goal of the first portion of this dissertation was to explore several aspects of monolignol oxidative coupling using high performance liquid chromatography (HPLC). These aspects included the study of relative reaction rates, both with respect to monolignol conversion and product formation, and the effects of solvent composition on product distribution. Electrospray ionization mass spectrometry (ESI-MS) was an important analytical tool for characterizing many coupling products, especially higher oligomeric compounds. The insights acquired from these experiments contributed valuable information towards a fuller understanding of the lignification process.

Graphic 1

Plant secondary metabolites are a vital source of medicinally relevant compounds. These metabolites are involved in the plants’ highly dynamic chemical defense against environmental stressors such as UV light, predators, and pathogens. Elicitation is a process in which changes in plant secondary metabolism are induced by specific stressors to understand metabolic pathways involved in plant defense. The second portion of this dissertation focused on the study of metabolism, known as metabolomics. Methods development for sample preparation and data processing in untargeted metabolomics was applied to study elicitation of secondary metabolites in Lobelia Cardinalis hairy root cultures. This study specifically explored the potential of nanoparticles as a delivery system to enhance the elicitation effects of jasmonic acid. In this work, UHPLC-MS with high resolution accurate mass was used to evaluate the secondary metabolic response of L. Cardinalis hairy root cultures to jasmonic acid-loaded nanoparticles.

Graphic 2Graphic 3

Date:
Location:
CP 114