Mark Lovell

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  • Jack and Linda Gill Professor of Chemistry
  • Department Chair
  • Chemistry
  • Analytical
  • Biological
102 Chemistry-Physics Building
859-257-7070
Education

Ph.D. University of Kentucky, 1992

Research

Increasing evidence suggests alterations in zinc (Zn) homeostasis may contribute to neurodegeneration observed in the pathogenesis of Alzheimer’s disease (AD). Current studies from our laboratory show there are significant alterations in proteins responsible for the transport and sequestration of Zn (ZnT proteins) that occur early in the progression of AD. Our data also suggest that alterations of ZnT proteins and the corresponding disruption of Zn balance can contribute to increased oxidative damage in AD. Our current research centers around the use of Western blot analysis, immunohistochemistry/laser confocal microscopy and genetic manipulation of neuronal cell lines to study alterations of ZnT proteins. We also use GC-MS, HPLC, cell culture techniques and transgenic animals to correlate altered ZnT levels and markers of oxidative damage including oxidized DNA adducts and neurotoxic by-products of lipid peroxidation (4-hydroxynonenal, acrolein). Additional studies include analysis of by-products of RNA oxidation in the progression of AD and evaluation of the biological impact of RNA oxidation using primary rat cortical neuron cultures.

Representative composite of cells from a subject with mild cognitive impairment (MCI) double labeled for ZnT-6 (A; green) and MC-1 (B; red), a marker of early neurofibrillary tangle formation. Figure C is a merged image. Note considerable overlap between ZnT-6 and MC-1 immunostaining. Scale bar = 50 µm.

Visit the Alzheimer's Disease Research Center.

Graduate Training
Analytical and Biological Chemistry
Selected Publications: 

Journal Articles

  • M.A. Bradley-Whitman and M.A. Lovell*, Mass spectrometry and studies of nucleic        acid oxidation in neurodegenerative diseases”, (Invited Review), J. Anal. Bioanal. Chem,    In press, (2013).
  • M. A. Bradley-Whitman, M. D. Timmons, T. L. Beckett, M. P. Murphy, B. C. Lynn, and M.A. Lovell* “Nucleic acid oxidation: an early feature of Alzheimer’s disease” J. Neurochem., In press, (2013).
  • M.D. Timmons, M.A. Bradley, M.A. Lovell and B.C. Lynn, “Changes in the mitochondrial lipidome in the progression of Alzheimer’s disease”, J. Lipid Res. In press,   (2013).
  • M.A. Bradley and M.A. Lovell* “Epigenetic changes in the brain in the progression of Alzheimer’s disease”, Invited article, Mech. Ageing Dev. In press, (2013).  
  • M.A. Lovell*, M.A. Bradley and S.X. Fister, “4-Hydroxyhexenal (HHE) impairs glutamate transport in astrocyte cultures”, J. Alzheimer’s Dis. Epub ahead of print (2012).
  • F.A. Schmitt, P.T. Nelson, E. Abner, S. Shceff, G.A. Jicha, C. Smith, G. Cooper, M. Mendiondo, D. D. Danner, L.J. Van Eldik, A. Caban-Holt, M.A. Lovell, and R.J. Kryscio, “University of Kentucky Sanders-Brown Healthy Brain Aging Volunteers:  Donor charachteristics, procedures and neuropathology”, Curr. Alzheimer’s Res. 9:724-733, (2012). 
  • G. Lyubartseva and M.A. Lovell*, “A potential role for zinc alterations in the pathogenesis of Alzheimer’s disease” Invited Review, Biofactors, 38:98-106, (2012).
  • A.M. Weidner, M.A. Bradley, T.L. Beckett, D.M. Niedowicz, A.L. Dowling, S.V. Matveev, H. Levine III, M.A. Lovell* and M.P. Murphy*, “RNA oxidation adducts 8-OHG change with Aß42 levels in late-stage Alzheimer’s disease”, PLoS One, 6:e24930, (2011). 
  • M.D. Timmons, M.A. Bradley, M.A. Lovell and B.C. Lynn, “Procedure for the isolation of mitochondria, cytosolic and nuclear material from a single piece of neurological tissue for high-throughput mass spectral analysis”, J. Neurosci. Methods 197:279-282, (2011).  
  •  M.A. Lovell,* S. Soman and M.A. Bradley, “Increased DNA and RNA oxidation in Preclinical Alzheimer’s disease (PCAD) brain”, Mech. Aging and Dev., Invited article, Mech. Ageing Dev. 132:443-448, (2011).
  • M.A. Bradley, S. Xiong, W. R. Markesbery and M.A. Lovell*, “Elevated 4-hydroxyhexenal in Alzheimer’s Disease (AD) Progression”, Neurobiol. Aging, [Epub ahead of print], (2010). 
  • M.A. Bradley, S. Xiong, W.R. Markesbery and M.A. Lovell*, “Increased levels of 4-hydroxynonenal and acrolein in the brain in preclinical Alzheimer’s disease (PCAD)”, Free Radic. Biol. Med., 48:1570-1576, (2010). 
  • B.C. Lynn, J. Wang, W.R. Markesbery and M.A. Lovell, “Quantitative Changes in the Mitochondrial Proteome from Subjects with Mild Cognitive Impairment, Early Stage, and Late-Stage Alzheimer’s Disease”, J. Alzheimer’s Dis.  19:325-339, (2010).
  • G. Lyubartseva, J.L. Smith, W.R. Markesbery and M.A. Lovell*, “Alterations of Zinc Transporter Proteins ZnT-1, ZnT-4 and ZnT-6 in Preclinical Alzheimer’s Disease Brain”, Brain Pathol., 20:343-350, (2010).  
  • M.A. Lovell*, S. Xiong, G. Lyubartseva and W.R. Markesbery, “Organoselenium (Sel-Plex Diet) Decreases Amyloid Burden and RNA and DNA Oxidative Damage in APP/PS1 Mice”, Free Radic. Biol. Med., 46:1527-1533, (2009).
  • Y.J. Fu, M.A. Lovell and B.C. Lynn, “Quantitative Proteomic Analysis of Mitochondria in Aging PS-1 Transgenic Mice”, Cell. Mol. Neurobiol., 29:649-664, (2009).
  • M.A. Lovell*, “A Potential Role for Alterations of Zinc and Zinc Transport Proteins in the Progression of Alzheimer’s Disease”, (Invited Review) J. Alzheimer’s Disease, 16:471-483, (2009).     
  • C.D. Smith, H. Chebrolu, A.H. Andersen, D.A. Powell, M.A. Lovell, S. Xiong, and B.T. Gold, “White Matter Diffusion Alterations in Normal Women at Risk of Alzheimer’s Disease”, Neurobiol. Aging, 31:122-131 (2010)  [Epub ahead of print; doi:10.1016/jneurobiolaging.2008.08.006], (2008). 
  • C. X. Shao, J. Wang, W. R. Markesbery and M. A. Lovell*, “Decreased Ogg1 Based Excision Repair in Amnestic Mild Cognitive Impairment”, Free Radic. Biol. Med. 45:813-819, (2008).
  • J.A. Sonnen, J.C. Breitner, M.A. Lovell, W.R. Markesbery, J.F. Quinn and T.J. Montine, “Free Radical-Mediated Damage to Brain in Alzheimer’s Disease and its Transgenic Mouse Models”, (Invited Review) Free Radic. Biol. Med.45:219-230, (2008).
  • M. A. Lovell*, B. C. Lynn, S. Xiong, J. F. Quinn, J. Kaye and W. R. Markesbery, “An Aberrant Protein Complex as a Biomarker of Alzheimer’s Disease”, Neurology, 70:2212-2218, (2008).
  • M. A. Lovell* and W. R. Markesbery, “Oxidative Modification of RNA in Mild Cognitive Impairment”, Neurobiol. Dis., 29:169-175, (2008).
  • M. A. Lovell* and W. R. Markesbery, “Oxidative DNA damage in mild cognitive impairment and late-stage Alzheimer’s disease”, (Invited Review) Nucleic Acids Res., 35:7497-9504, (2007).

Book Chapters

  •  M.A. Lovell*, “Zinc transporters in the Progression of Alzheimer’s Disease”, In:  Membrane Transporters in Drug Discovery and Development:  Methods and Protocols, (Methods in Molecular Biology Series), Q. Yan, Ed., 2010.
  • J. D. Robertson and M. A. Lovell, "Applications of Radioanalytical Chemistry to Alzheimer's Disease," In: Radioanalytical Methods in Interdisciplinary Research, C. A. Laue and K. L. Nash, Eds., 2004, pp. 298-306.
  • M. A. Lovell and W. R. Markesbery, "Analysis of Aldehydic Markers of Lipid Peroxidation in Biological Tissues by High-Pressure Liquid Chromatography with Fluorescence Detection," In: Methods in Biological Oxidative Stress, K. Hensley, Ed., 2003, pp. 17-21.
  • W. R. Markesbery, T. J. Montine and M. A. Lovell, "Oxidative Alteration in Neurodegenerative Diseases," In: The Pathogenesis of Neurodegenerative Disorders, M. P. Mattson, Ed., Humana Press, 2001, pp. 21-51.
  • M. A. Lovell, W. D. Ehmann, W. R. Markesbery, S. Melethil, C. R. Swyt and P. F. Zatta, "Standardization in Biological Analyses of Aluminum: What are the Needs?" In: Research Issues in Aluminum Toxicity, R. A. Yokel and M. S. Golub, Eds., Taylor and Francis, 1997.
PubMed Publications*: 
  • Ellison, EM ;Bradley-Whitman, MA ;Lovell, MA "Single-Base Resolution Mapping of 5-Hydroxymethylcytosine Modifications in Hippocampus of Alzheimer's Disease Subjects." Journal of molecular neuroscience : MN 63, 2 (2017): 185-197. Details. Full text
  • Sompol, P ;Furman, JL ;Pleiss, MM ;Kraner, SD ;Artiushin, IA ;, ;Quintero, JE ;Simmerman, LA ;Beckett, TL ;Lovell, MA ;Murphy, MP ;Gerhardt, GA ;Norris, CM "Calcineurin/NFAT Signaling in Activated Astrocytes Drives Network Hyperexcitability in Aβ-Bearing Mice." The Journal of neuroscience : the official journal of the Society for Neuroscience 37, 25 (2017): 6132-6148. Details. Full text
  • Ellison, EM ;Abner, EL ;Lovell, MA "Multiregional analysis of global 5-methylcytosine and 5-hydroxymethylcytosine throughout the progression of Alzheimer's disease." Journal of neurochemistry 140, 3 (2017): 383-394. Details. Full text
  • Lovell, MA ;Lynn, BC ;Fister, S.;Bradley-Whitman, M ;Murphy, MP ;Beckett, TL ;Norris, CM "A Novel Small Molecule Modulator of Amyloid Pathology." Journal of Alzheimer's disease : JAD 53, 1 (2016): 273-87. Details. Full text
  • Bradley-Whitman, MA ;Lovell, MA "Biomarkers of lipid peroxidation in Alzheimer disease (AD): an update." Archives of toxicology 89, 7 (2015): 1035-44. Details. Full text
  • Bradley-Whitman, MA ;Timmons, MD ;Beckett, TL ;Murphy, MP ;Lynn, BC ;Lovell, MA "Nucleic acid oxidation: an early feature of Alzheimer's disease." Journal of neurochemistry 128, 2 (2014): 294-304. Details. Full text
  • Bradley-Whitman, MA ;Lovell, MA "Epigenetic changes in the progression of Alzheimer's disease." Mechanisms of ageing and development 134, 10 (2013): 486-95. Details. Full text
  • Bradley, MA ;Xiong-Fister, S ;Markesbery, WR ;Lovell, MA "Elevated 4-hydroxyhexenal in Alzheimer's disease (AD) progression." Neurobiology of aging 33, 6 (2012): 1034-44. Details. Full text
  • Schmitt, FA ;Nelson, PT ;Abner, E ;Scheff, S ;Jicha, GA ;Smith, C ;Cooper, G ;Mendiondo, M ;Danner, DD ;Van Eldik, LJ ;Caban-Holt, A ;Lovell, MA ;Kryscio, RJ "University of Kentucky Sanders-Brown healthy brain aging volunteers: donor characteristics, procedures and neuropathology." Current Alzheimer research 9, 6 (2012): 724-33. Details. Full text
  • Lovell, MA ;Soman, S ;Bradley, MA "Oxidatively modified nucleic acids in preclinical Alzheimer's disease (PCAD) brain." Mechanisms of ageing and development 132, 8-9 (2011): 443-8. Details. Full text
  • Lovell, MA "Memories of Dr. William R. Markesbery." Neuromolecular medicine 13, 1 (2011): 15-6. Details. Full text
  • Timmons, MD ;Bradley, MA ;Lovell, MA ;Lynn, BC "Procedure for the isolation of mitochondria, cytosolic and nuclear material from a single piece of neurological tissue for high-throughput mass spectral analysis." Journal of neuroscience methods 197, 2 (2011): 279-82. Details. Full text
  • Smith, CD ;Chebrolu, H ;Andersen, AH ;Powell, DA ;Lovell, MA ;Xiong, S ;Gold, BT "White matter diffusion alterations in normal women at risk of Alzheimer's disease." Neurobiology of aging 31, 7 (2010): 1122-31. Details. Full text
  • Bradley, MA ;Markesbery, WR ;Lovell, MA "Increased levels of 4-hydroxynonenal and acrolein in the brain in preclinical Alzheimer disease." Free radical biology & medicine 48, 12 (2010): 1570-6. Details. Full text
  • Lovell, MA ;Xiong, S ;Lyubartseva, G ;Markesbery, WR "Organoselenium (Sel-Plex diet) decreases amyloid burden and RNA and DNA oxidative damage in APP/PS1 mice." Free radical biology & medicine 46, 11 (2009): 1527-33. Details. Full text
  • Fu, YJ ;Xiong, S ;Lovell, MA ;Lynn, BC "Quantitative proteomic analysis of mitochondria in aging PS-1 transgenic mice." Cellular and molecular neurobiology 29, 5 (2009): 649-64. Details. Full text
  • Shao, C ;Xiong, S ;Li, GM ;Gu, L ;Mao, G ;Markesbery, WR ;Lovell, MA "Altered 8-oxoguanine glycosylase in mild cognitive impairment and late-stage Alzheimer's disease brain." Free radical biology & medicine 45, 6 (2008): 813-9. Details. Full text
  • Lovell, MA ;Markesbery, WR "Oxidatively modified RNA in mild cognitive impairment." Neurobiology of disease 29, 2 (2008): 169-75. Details. Full text
  • Lovell, MA ;Lynn, BC ;Xiong, S ;Quinn, JF ;Kaye, J ;Markesbery, WR "An aberrant protein complex in CSF as a biomarker of Alzheimer disease." Neurology 70, 23 (2008): 2212-8. Details. Full text
  • Markesbery, WR ;Lovell, MA "Damage to lipids, proteins, DNA, and RNA in mild cognitive impairment." Archives of neurology 64, 7 (2007): 954-6. Details. Full text
  • Lovell, MA ;Markesbery, WR "Oxidative damage in mild cognitive impairment and early Alzheimer's disease." Journal of neuroscience research 85, 14 (2007): 3036-40. Details. Full text
  • Xiong, S ;Markesbery, WR ;Shao, C ;Lovell, MA "Seleno-L-methionine protects against beta-amyloid and iron/hydrogen peroxide-mediated neuron death." Antioxidants & redox signaling 9, 4 (2007): 457-67. Details. Full text
  • Mehta, SG ;Watts, GD ;Adamson, JL ;Hutton, M ;Umberger, G ;Xiong, S ;Ramdeen, S ;Lovell, MA ;Kimonis, VE ;Smith, CD "APOE is a potential modifier gene in an autosomal dominant form of frontotemporal dementia (IBMPFD)." Genetics in medicine : official journal of the American College of Medical Genetics 9, 1 (2007): 9-13. Details. Full text
  • Lovell, MA ;Markesbery, WR "Amyloid beta peptide, 4-hydroxynonenal and apoptosis." Current Alzheimer research 3, 4 (2006): 359-64. Details. Full text
  • Shao, C ;Roberts, KN ;Markesbery, WR ;Scheff, SW ;Lovell, MA "Oxidative stress in head trauma in aging." Free radical biology & medicine 41, 1 (2006): 77-85. Details. Full text
  • Lovell, MA ;Smith, JL ;Markesbery, WR "Elevated zinc transporter-6 in mild cognitive impairment, Alzheimer disease, and pick disease." Journal of neuropathology and experimental neurology 65, 5 (2006): 489-98. Details. Full text
  • Smith, JL ;Xiong, S ;Markesbery, WR ;Lovell, MA "Altered expression of zinc transporters-4 and -6 in mild cognitive impairment, early and late Alzheimer's disease brain." Neuroscience 140, 3 (2006): 879-88. Details. Full text
  • Wang, J.;Markesbery, WR ;Lovell, MA "Increased oxidative damage in nuclear and mitochondrial DNA in mild cognitive impairment." Journal of neurochemistry 96, 3 (2006): 825-32. Details. Full text
  • Liu, X.;Lovell, MA ;Lynn, BC "Detection and quantification of endogenous cyclic DNA adducts derived from trans-4-hydroxy-2-nonenal in human brain tissue by isotope dilution capillary liquid chromatography nanoelectrospray tandem mass spectrometry." Chemical research in toxicology 19, 5 (2006): 710-8. Details. Full text
  • Smith, JL ;Xiong, S ;Lovell, MA "4-Hydroxynonenal disrupts zinc export in primary rat cortical cells." Neurotoxicology 27, 1 (2006): 1-5. Details. Full text
  • Williams, TI ;Lynn, BC ;Markesbery, WR ;Lovell, MA "Increased levels of 4-hydroxynonenal and acrolein, neurotoxic markers of lipid peroxidation, in the brain in Mild Cognitive Impairment and early Alzheimer's disease." Neurobiology of aging 27, 8 (2006): 1094-9. Details. Full text
  • Lovell, MA ;Geiger, H ;Van Zant, GE ;Lynn, BC ;Markesbery, WR "Isolation of neural precursor cells from Alzheimer's disease and aged control postmortem brain." Neurobiology of aging 27, 7 (2006): 909-17. Details. Full text
  • Smith, CD ;Kryscio, RJ ;Schmitt, FA ;Lovell, MA ;Blonder, LX ;Rayens, WS ;Andersen, AH "Longitudinal functional alterations in asymptomatic women at risk for Alzheimer's disease." Journal of neuroimaging : official journal of the American Society of Neuroimaging 15, 3 (2005): 271-7. Details. Full text
  • Williams, TI ;Lovell, MA ;Lynn, BC "Analysis of derivatized biogenic aldehydes by LC tandem mass spectrometry." Analytical chemistry 77, 10 (2005): 3383-9. Details. Full text
  • Wang, J.;Xiong, S ;Xie, C ;Markesbery, WR ;Lovell, MA "Increased oxidative damage in nuclear and mitochondrial DNA in Alzheimer's disease." Journal of neurochemistry 93, 4 (2005): 953-62. Details. Full text
  • Lovell, MA ;Xiong, S ;Markesbery, WR ;Lynn, BC "Quantitative proteomic analysis of mitochondria from primary neuron cultures treated with amyloid beta peptide." Neurochemical research 30, 1 (2005): 113-22. Details. Full text
  • Markesbery, WR ;Kryscio, RJ ;Lovell, MA ;Morrow, JD "Lipid peroxidation is an early event in the brain in amnestic mild cognitive impairment." Annals of neurology 58, 5 (2005): 730-5. Details. Full text
  • Liu, X.;Lovell, MA ;Lynn, BC "Development of a method for quantification of acrolein-deoxyguanosine adducts in DNA using isotope dilution-capillary LC/MS/MS and its application to human brain tissue." Analytical chemistry 77, 18 (2005): 5982-9. Details. Full text
  • Lovell, MA ;Markesbery, WR "Ectopic expression of Musashi-1 in Alzheimer disease and Pick disease." Journal of neuropathology and experimental neurology 64, 8 (2005): 675-80. Details. Full text
  • Lovell, MA ;Xiong, S ;Xie, C ;Davies, P ;Markesbery, WR "Induction of hyperphosphorylated tau in primary rat cortical neuron cultures mediated by oxidative stress and glycogen synthase kinase-3." Journal of Alzheimer's disease : JAD 6, 6 (2004): 659-71; discussion 673-81. Details. Full text
  • Lovell, MA ;Xie, C ;Xiong, S ;Markesbery, WR "Wilms' tumor suppressor (WT1) is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer's disease." Brain research 983, 1-2 (2003): 84-96. Details. Full text
  • Lovell, MA ;Xie, C ;Xiong, S ;Markesbery, WR "Protection against amyloid beta peptide and iron/hydrogen peroxide toxicity by alpha lipoic acid." Journal of Alzheimer's disease : JAD 5, 3 (2003): 229-39. Details. Full text
  • Xie, C ;Lovell, MA ;Xiong, S ;Kindy, MS ;Guo, J.;Xie, J.;Amaranth, V ;Montine, TJ ;Markesbery, WR "Expression of glutathione-S-transferase isozyme in the SY5Y neuroblastoma cell line increases resistance to oxidative stress." Free radical biology & medicine 31, 1 (2001): 73-81. Details. Full text
  • Lovell, MA ;Markesbery, WR "Ratio of 8-hydroxyguanine in intact DNA to free 8-hydroxyguanine is increased in Alzheimer disease ventricular cerebrospinal fluid." Archives of neurology 58, 3 (2001): 392-6. Details. Full text
  • Lovell, MA ;Xie, C ;Markesbery, WR "Acrolein, a product of lipid peroxidation, inhibits glucose and glutamate uptake in primary neuronal cultures." Free radical biology & medicine 29, 8 (2000): 714-20. Details. Full text
  • Hong, CB ;Fredenburg, AM ;Dickey, KM ;Lovell, MA ;Yokel, RA "Glomerular lesions in male rabbits treated with aluminium lactate: with special reference to microaneurysm formation." Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 52, 2 (2000): 139-43. Details. Full text
  • Xie, C ;Markesbery, WR ;Lovell, MA "Survival of hippocampal and cortical neurons in a mixture of MEM+ and B27-supplemented neurobasal medium." Free radical biology & medicine 28, 5 (2000): 665-72. Details. Full text
  • Lovell, MA ;Xie, C ;Gabbita, SP ;Markesbery, WR "Decreased thioredoxin and increased thioredoxin reductase levels in Alzheimer's disease brain." Free radical biology & medicine 28, 3 (2000): 418-27. Details. Full text
  • Lovell, MA ;Xie, C ;Markesbery, WR "Decreased base excision repair and increased helicase activity in Alzheimer's disease brain." Brain research 855, 1 (2000): 116-23. Details. Full text
  • Gabbita, SP ;Aksenov, MY ;Lovell, MA ;Markesbery, WR "Decrease in peptide methionine sulfoxide reductase in Alzheimer's disease brain." Journal of neurochemistry 73, 4 (1999): 1660-6. Details. Full text
  • Lovell, MA ;Xie, C ;Markesbery, WR "Protection against amyloid beta peptide toxicity by zinc." Brain research 823, 1-2 (1999): 88-95. Details. Full text
  • Lovell, MA ;Gabbita, SP ;Markesbery, WR "Increased DNA oxidation and decreased levels of repair products in Alzheimer's disease ventricular CSF." Journal of neurochemistry 72, 2 (1999): 771-6. Details. Full text
  • Gabbita, SP ;Lovell, MA ;Markesbery, WR "Increased nuclear DNA oxidation in the brain in Alzheimer's disease." Journal of neurochemistry 71, 5 (1998): 2034-40. Details. Full text
  • Lovell, MA ;Robertson, JD ;Teesdale, WJ ;Campbell, JL ;Markesbery, WR "Copper, iron and zinc in Alzheimer's disease senile plaques." Journal of the neurological sciences 158, 1 (1998): 47-52. Details. Full text
  • Bruce-Keller, AJ ;Li, YJ ;Lovell, MA ;Kraemer, PJ ;Gary, DS ;Brown, RR ;Markesbery, WR ;Mattson, MP "4-Hydroxynonenal, a product of lipid peroxidation, damages cholinergic neurons and impairs visuospatial memory in rats." Journal of neuropathology and experimental neurology 57, 3 (1998): 257-67. Details. Full text
  • Prasad, MR ;Lovell, MA ;Yatin, M ;Dhillon, H ;Markesbery, WR "Regional membrane phospholipid alterations in Alzheimer's disease." Neurochemical research 23, 1 (1998): 81-8. Details.
  • Lovell, MA ;Xie, C ;Markesbery, WR "Decreased glutathione transferase activity in brain and ventricular fluid in Alzheimer's disease." Neurology 51, 6 (1998): 1562-6. Details.
  • Xie, C ;Lovell, MA ;Markesbery, WR "Glutathione transferase protects neuronal cultures against four hydroxynonenal toxicity." Free radical biology & medicine 25, 8 (1998): 979-88. Details. Full text
  • Mark, RJ ;Lovell, MA ;Markesbery, WR ;Uchida, K.;Mattson, MP "A role for 4-hydroxynonenal, an aldehydic product of lipid peroxidation, in disruption of ion homeostasis and neuronal death induced by amyloid beta-peptide." Journal of neurochemistry 68, 1 (1997): 255-64. Details. Full text
  • Xie, CX ;Mattson, MP ;Lovell, MA ;Yokel, RA "Intraneuronal aluminum potentiates iron-induced oxidative stress in cultured rat hippocampal neurons." Brain research 743, 1-2 (1996): 271-7. Details. Full text
  • Lovell, MA ;Ehmann, WD ;Markesbery, WR ;Melethil, S ;Swyt, CR ;Zatta, PF "Standardization in biological analyses of aluminum: what are the needs?" Journal of toxicology and environmental health 48, 6 (1996): 637-48. Details.
  • Lovell, MA ;Ehmann, WD ;Butler, SM ;Markesbery, WR "Elevated thiobarbituric acid-reactive substances and antioxidant enzyme activity in the brain in Alzheimer's disease." Neurology 45, 8 (1995): 1594-601. Details.
  • Kasarskis, EJ ;Tandon, L ;Lovell, MA ;Ehmann, WD "Aluminum, calcium, and iron in the spinal cord of patients with sporadic amyotrophic lateral sclerosis using laser microprobe mass spectroscopy: a preliminary study." Journal of the neurological sciences 130, 2 (1995): 203-8. Details. Full text
  • Mattson, MP ;Lovell, MA ;Furukawa, K.;Markesbery, WR "Neurotrophic factors attenuate glutamate-induced accumulation of peroxides, elevation of intracellular Ca2+ concentration, and neurotoxicity and increase antioxidant enzyme activities in hippocampal neurons." Journal of neurochemistry 65, 4 (1995): 1740-51. Details. Full text
  • Mattson, MP ;Lovell, MA ;Ehmann, WD ;Markesbery, WR "Comparison of the effects of elevated intracellular aluminum and calcium levels on neuronal survival and tau immunoreactivity." Brain research 602, 1 (1993): 21-31. Details. Full text
  • Lovell, MA ;Ehmann, WD ;Markesbery, WR "Laser microprobe analysis of brain aluminum in Alzheimer's disease." Annals of neurology 33, 1 (1993): 36-42. Details. Full text
  • Markesbery, WR ;Lovell, MA "DNA oxidation in Alzheimer's disease." Antioxidants & redox signaling 8, 11-12 (1969): 2039-45. Details. Full text
  • Rulon, LL ;Robertson, JD ;Lovell, MA ;Deibel, MA ;Ehmann, WD ;Markesber, WR "Serum zinc levels and Alzheimer's disease." Biological trace element research 75, 1-3 (1969): 79-85. Details. Full text
  • Wenner, BR ;Lovell, MA ;Lynn, BC "Proteomic analysis of human ventricular cerebrospinal fluid from neurologically normal, elderly subjects using two-dimensional LC-MS/MS." Journal of proteome research 3, 1 (1969): 97-103. Details. Full text
  • Markesbery, WR ;Lovell, MA "Four-hydroxynonenal, a product of lipid peroxidation, is increased in the brain in Alzheimer's disease." Neurobiology of aging 19, 1 (1969): 33-6. Details. Full text
  • Lovell, MA ;Robertson, JD ;Buchholz, BA ;Xie, C ;Markesbery, WR "Use of bomb pulse carbon-14 to age senile plaques and neurofibrillary tangles in Alzheimer's disease." Neurobiology of aging 23, 2 (1969): 179-86. Details. Full text
  • Lovell, MA ;Ehmann, WD ;Mattson, MP ;Markesbery, WR "Elevated 4-hydroxynonenal in ventricular fluid in Alzheimer's disease." Neurobiology of aging 18, 5 (1969): 457-61. Details. Full text
  • Lovell, MA ;Xie, C ;Markesbery, WR "Acrolein is increased in Alzheimer's disease brain and is toxic to primary hippocampal cultures." Neurobiology of aging 22, 2 (1969): 187-94. Details. Full text
  • Bradley-Whitman, MA ;Abner, E ;Lynn, BC ;Lovell, MA "A Novel Plasma Based Biomarker of Alzheimer's Disease." Journal of Alzheimer's disease : JAD 47, 3 (0): 761-71. Details. Full text
  • Lovell, MA ;Abner, E ;Kryscio, R.;Xu, L.;Fister, SX ;Lynn, BC "Calcium Channel Blockers, Progression to Dementia, and Effects on Amyloid Beta Peptide Production." Oxidative medicine and cellular longevity 2015, (0): 787805. Details. Full text
  • Lovell, MA "A potential role for alterations of zinc and zinc transport proteins in the progression of Alzheimer's disease." Journal of Alzheimer's disease : JAD 16, 3 (0): 471-83. Details. Full text
  • Lynn, BC ;Wang, J.;Markesbery, WR ;Lovell, MA "Quantitative changes in the mitochondrial proteome from subjects with mild cognitive impairment, early stage, and late stage Alzheimer's disease." Journal of Alzheimer's disease : JAD 19, 1 (0): 325-39. Details. Full text
  • Lovell, MA ;Markesbery, WR "Oxidative DNA damage in mild cognitive impairment and late-stage Alzheimer's disease." Nucleic acids research 35, 22 (0): 7497-504. Details. Full text
  • Lovell, MA ;Smith, JL ;Xiong, S ;Markesbery, WR "Alterations in zinc transporter protein-1 (ZnT-1) in the brain of subjects with mild cognitive impairment, early, and late-stage Alzheimer's disease." Neurotoxicity research 7, 4 (0): 265-71. Details. Full text
  • Mao, G ;Pan, X ;Zhu, BB ;Zhang, Y.;Yuan, F ;Huang, J.;Lovell, MA ;Lee, MP ;Markesbery, WR ;Li, GM ;Gu, L "Identification and characterization of OGG1 mutations in patients with Alzheimer's disease." Nucleic acids research 35, 8 (0): 2759-66. Details. Full text
  • Lovell, MA ;Bradley, MA ;Fister, SX "4-Hydroxyhexenal (HHE) impairs glutamate transport in astrocyte cultures." Journal of Alzheimer's disease : JAD 32, 1 (0): 139-46. Details. Full text
  • Bradley-Whitman, MA ;Roberts, KN ;Abner, EL ;Scheff, SW ;Lynn, BC ;Lovell, MA "A novel method for the rapid detection of post-translationally modified visinin-like protein 1 in rat models of brain injury." Brain injury 32, 3 (0): 363-380. Details. Full text
  • Lovell, MA "Similarities and differences between mild cognitive impairment and Alzheimer's disease." Journal of Alzheimer's disease : JAD 19, 1 (0): 219. Details. Full text
  • Weidner, AM ;Bradley, MA ;Beckett, TL ;Niedowicz, DM ;Dowling, AL ;Matveev, SV ;LeVine H, 3rd ;Lovell, MA ;Murphy, MP "RNA oxidation adducts 8-OHG and 8-OHA change with Aβ42 levels in late-stage Alzheimer's disease." PloS one 6, 9 (0): e24930. Details. Full text
* Publications are automatically pulled from pubmed.gov based on a user-specific query. Results may include incorrect citations. See: Tutorial on improving PubMed results.
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