Anne-Frances Miller
Research Interests:
- Enzymes
- redox catalysis
- flavin-mediated reactions
- flavin redox
- and photochemistry
- enzyme-functionalized electrodes and membranes
- spectroscopy
- mechanistic enzymology
- enzyme engineering
Education
Ph.D Yale University, 1989
Postdoctoral, Massachusetts Institute of Technology, 1989-90
Postdoctoral Fellow, Brandeis Univ. 1990-92
Research
- Enzymatic Redox Catalysis - Miller Group website
- See the Group Website !! (College website maintained as finances allow)
Graduate Training
Bioinorganic Chemistry, Spectroscopy, Biochemistry
PubMed Publications*:
- "Contrasting roles for two conserved arginines: Stabilizing flavin semiquinone or quaternary structure, in bifurcating electron transfer flavoproteins." The Journal of biological chemistry 298, 4 (2022): 101733. Details. Full text
- "Assignments of <sup>19</sup>F NMR resonances and exploration of dynamics in a long-chain flavodoxin." Archives of biochemistry and biophysics 703, (2021): 108839. Details. Full text
- "Photogeneration and reactivity of flavin anionic semiquinone in a bifurcating electron transfer flavoprotein." Biochimica et biophysica acta. Bioenergetics 1862, 7 (2021): 148415. Details. Full text
- "Tuning the Quantum Chemical Properties of Flavins via Modification at C8." The journal of physical chemistry. B 125, 46 (2021): 12654-12669. Details. Full text
- "Tuning of p<i>K<sub>a</sub></i> values activates substrates in flavin-dependent aromatic hydroxylases." The Journal of biological chemistry 295, 12 (2020): 3965-3981. Details. Full text
- "Spectroscopic evidence for direct flavin-flavin contact in a bifurcating electron transfer flavoprotein." The Journal of biological chemistry 295, 36 (2020): 12618-12634. Details. Full text
- "Spectroscopic, thermodynamic and computational evidence of the locations of the FADs in the nitrogen fixation-associated electron transfer flavoprotein." Chemical science 10, 33 (2019): 7762-7772. Details. Full text
- "The catalytic mechanism of electron-bifurcating electron transfer flavoproteins (ETFs) involves an intermediary complex with NAD<sup/>." The Journal of biological chemistry 294, 9 (2019): 3271-3283. Details. Full text
- "The catalytic mechanism of electron-bifurcating electron transfer flavoproteins (ETFs) involves an intermediary complex with NAD<sup/>." The Journal of biological chemistry 294, 9 (2019): 3271-3283. Details. Full text
- "Distinct properties underlie flavin-based electron bifurcation in a novel electron transfer flavoprotein FixAB from <i>Rhodopseudomonas palustris</i>." The Journal of biological chemistry 293, 13 (2018): 4688-4701. Details. Full text
- "Informing Efforts to Develop Nitroreductase for Amine Production." Molecules (Basel, Switzerland) 23, 2 (2018): Details. Full text
- "Mechanistic insights into energy conservation by flavin-based electron bifurcation." Nature chemical biology 13, 6 (2017): 655-659. Details. Full text
- "Inverted Micelle-in-Micelle Configuration in Cationic/Carbohydrate Surfactant Mixtures." Chemphyschem : a European journal of chemical physics and physical chemistry 18, 1 (2017): 79-86. Details. Full text
- "Defining Electron Bifurcation in the Electron-Transferring Flavoprotein Family." Journal of bacteriology 199, 21 (2017): Details. Full text
- "The Electron Bifurcating FixABCX Protein Complex from Azotobacter vinelandii: Generation of Low-Potential Reducing Equivalents for Nitrogenase Catalysis." Biochemistry 56, 32 (2017): 4177-4190. Details. Full text
- "A Single Outer-Sphere Mutation Stabilizes apo-Mn Superoxide Dismutase by 35 °C and Disfavors Mn Binding." Biochemistry 56, 29 (2017): 3787-3799. Details. Full text
- "Equilibrium and ultrafast kinetic studies manipulating electron transfer: A short-lived flavin semiquinone is not sufficient for electron bifurcation." The Journal of biological chemistry 292, 34 (2017): 14039-14049. Details. Full text
- "Mechanism-Informed Refinement Reveals Altered Substrate-Binding Mode for Catalytically Competent Nitroreductase." Structure (London, England : 1993) 25, 7 (2017): 978-987.e4. Details. Full text
- "Layer-by-Layer-Assembled Laccase Enzyme on Stimuli-Responsive Membranes for Chloro-Organics Degradation." ACS applied materials & interfaces 9, 17 (2017): 14858-14867. Details. Full text
- "Flavin-sensitized electrode system for oxygen evolution using photo-electrocatalysis." Chemical communications (Cambridge, England) 52, 57 (2016): 8834-7. Details. Full text
- "Electron bifurcation." Current opinion in chemical biology 31, (2016): 146-52. Details. Full text
- "Understanding the broad substrate repertoire of nitroreductase based on its kinetic mechanism." The Journal of biological chemistry 289, 22 (2014): 15203-14. Details. Full text
- "Multitechnique investigation of the pH dependence of phosphate induced transformations of ZnO nanoparticles." Environmental science & technology 48, 9 (2014): 4757-64. Details. Full text
- "Ether bridge formation in loline alkaloid biosynthesis." Phytochemistry 98, (2014): 60-8. Details. Full text
- "Superoxide dismutases: ancient enzymes and new insights." FEBS letters 586, 5 (2012): 585-95. Details. Full text
- "Synthesis and structural characterization of crystalline nonacenes." Angewandte Chemie (International ed. in English) 50, 31 (2011): 7013-7. Details. Full text
- "15N solid-state NMR as a probe of flavin H-bonding." The journal of physical chemistry. B 115, 24 (2011): 7788-98. Details. Full text
- "15N-NMR characterization of His residues in and around the active site of FeSOD." Biochimica et biophysica acta 1804, 2 (2010): 275-84. Details. Full text
- "Sialic acid transport and catabolism are cooperatively regulated by SiaR and CRP in nontypeable Haemophilus influenzae." BMC microbiology 10, (2010): 240. Details. Full text
- "The shortest wire." Proceedings of the National Academy of Sciences of the United States of America 105, 21 (2008): 7341-2. Details. Full text
- "Carbon-centered radicals in isolated soy proteins." Journal of food science 73, 3 (2008): C222-6. Details. Full text
- "Redox tuning over almost 1 V in a structurally conserved active site: lessons from Fe-containing superoxide dismutase." Accounts of chemical research 41, 4 (2008): 501-10. Details. Full text
- "How can a single second sphere amino acid substitution cause reduction midpoint potential changes of hundreds of millivolts?" Journal of the American Chemical Society 129, 32 (2007): 9927-40. Details. Full text
- "15N solid-state NMR provides a sensitive probe of oxidized flavin reactive sites." Journal of the American Chemical Society 128, 47 (2006): 15200-8. Details. Full text
- "Evidence for polyproline II helical structure in short polyglutamine tracts." Journal of molecular biology 361, 2 (2006): 362-71. Details. Full text
- "The crucial importance of chemistry in the structure-function link: manipulating hydrogen bonding in iron-containing superoxide dismutase." Biochemistry 45, 4 (2006): 1151-61. Details. Full text
- "Superoxide dismutases: active sites that save, but a protein that kills." Current opinion in chemical biology 8, 2 (2004): 162-8. Details. Full text
- "Proton-coupled electron transfer in Fe-superoxide dismutase and Mn-superoxide dismutase." Journal of inorganic biochemistry 93, 1-2 (2003): 71-83. Details. Full text
- "Comparison and contrasts between the active site PKs of Mn-superoxide dismutase and those of Fe-superoxide dismutase." Journal of the American Chemical Society 124, 50 (2002): 15064-75. Details. Full text
- "Flavin thermodynamics explain the oxygen insensitivity of enteric nitroreductases." Biochemistry 41, 48 (2002): 14197-205. Details. Full text
- "Hydrogen-bond-mediated tuning of the redox potential of the non-heme Fe site of superoxide dismutase." Journal of the American Chemical Society 124, 14 (2002): 3482-3. Details. Full text
- "Structures of nitroreductase in three states: effects of inhibitor binding and reduction." The Journal of biological chemistry 277, 13 (2002): 11513-20. Details. Full text
- "Retro-nitroreductase, a putative evolutionary precursor to Enterobacter cloacae strain 96-3 nitroreductase." Antioxidants & redox signaling 3, 5 (2001): 747-55. Details. Full text
- "Host-guest study of left-handed polyproline II helix formation." Biochemistry 40, 48 (2001): 14376-83. Details. Full text
- "Mutational and spectroscopic studies of the significance of the active site glutamine to metal ion specificity in superoxide dismutase." Journal of inorganic biochemistry 80, 3-4 (2000): 247-56. Details. Full text
- "Reduction midpoint potentials of bifurcating electron transfer flavoproteins." Methods in enzymology 620, (0): 365-398. Details. Full text
- "Solid-state NMR of flavins and flavoproteins." Methods in molecular biology (Clifton, N.J.) 1146, (0): 307-40. Details. Full text
- "Antihyperglycemic profile of erinidine isolated from Hunteria umbellata seed." African journal of traditional, complementary, and alternative medicines : AJTCAM 10, 2 (0): 189-202. Details.
* Publications are automatically pulled from pubmed.gov based on a user-specific query. Results may include incorrect citations. See: Tutorial on improving PubMed results.