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Dr. Edward Merino from the University of Cincinnati will be presenting a seminar titled: Therapeutic targeting of cancer cells’ addiction to reactive oxygen.

Abstract
Cancer cells show diverse phenotypes with some tumors having excessive reactive oxygen species (ROS). The ROS drives signaling cascades involved in growth and leads to drug resistance by DNA oxidation. My lab has two goals. First, we examine the biological mechanism that some cancers cells elevate ROS and determine DNA damage in these cells. Second, we are working to turn high ROS states into an exploitable liability for these cancers. Our new agents are non-functional until ROS alters the agent and converts it into a lethal mode. This chemical biology research has produced positive results in a difficult to treat cancer called Acute Myeloid Leukemia.

Faculty Host: Jason DeRouchey