<i>TCF7L2</i> Genetic Variation Augments Incretin Resistance and Influences Response to a Sulfonylurea and Metformin: The Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans (SUGAR-MGH).
| Author | |
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| Abstract | :
The rs7903146 T allele in transcription-factor-7-like-2 (TCF7L2) is strongly associated with type 2 diabetes (T2D), but the mechanisms for increased risk remain unclear. We evaluated the physiologic and hormonal effects of TCF7L2 genotype before and after interventions that influence glucose physiology. |
| Year of Publication | :
2018
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| Journal | :
Diabetes care
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| Date Published | :
2018
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| ISSN Number | :
0149-5992
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| DOI | :
10.2337/dc17-1386
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| Short Title | :
Diabetes Care
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| Download citation |