Differential effects of cannabinoid CB1 inverse agonists and antagonists on impulsivity in male Sprague Dawley rats: identification of a possibly clinically relevant vulnerability involving the serotonin 5HT<sub>1A</sub> receptor.
| Author | |
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| Abstract | :
Cannabinoid CB1 inverse agonists hold therapeutic promise as appetite suppressants but have produced suicidal behaviors among a small subpopulation in clinical trials. Anatomical and pharmacological evidence implicate the 5HT serotonin receptor in suicide in humans and impulsivity in humans and animals. |
| Year of Publication | :
2017
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| Journal | :
Psychopharmacology
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| Volume | :
234
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| Issue | :
6
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| Number of Pages | :
1029-1043
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| ISSN Number | :
0033-3158
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| URL | :
https://doi.org/10.1007/s00213-017-4548-2
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| DOI | :
10.1007/s00213-017-4548-2
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| Short Title | :
Psychopharmacology (Berl)
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