Exercise training prevents ventricular tachycardia in CPVT1 due to reduced CaMKII-dependent arrhythmogenic Ca2+ release.
| Author | |
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| Abstract | :
Catecholaminergic polymorphic ventricular tachycardia type 1 (CPVT1) is caused by mutations in the cardiac ryanodine receptor (RyR2) that lead to disrupted Ca(2+) handling in cardiomyocytes and ventricular tachycardia. The aim of this study was to test whether exercise training could reduce the propensity for arrhythmias in mice with the CPVT1-causative missense mutation Ryr2-R2474S by restoring normal Ca(2+) handling. |
| Year of Publication | :
2016
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| Journal | :
Cardiovascular research
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| Volume | :
111
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| Issue | :
3
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| Number of Pages | :
295-306
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| Date Published | :
2016
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| ISSN Number | :
0008-6363
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| URL | :
https://academic.oup.com/cardiovascres/article-lookup/doi/10.1093/cvr/cvw095
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| DOI | :
10.1093/cvr/cvw095
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| Short Title | :
Cardiovasc Res
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