Pentosan polysulfate decreases myocardial expression of the extracellular matrix enzyme ADAMTS4 and improves cardiac function in vivo in rats subjected to pressure overload by aortic banding.
| Author | |
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| Abstract | :
We hypothesized that cleavage of the extracellular matrix (ECM) proteoglycans versican and aggrecan by ADAMTS (a disintegrin and metalloprotease with thrombospondin motifs) proteases, which contributes to stress-induced ECM-reorganization in atherogenesis and osteoarthritis, also play a role in heart failure development. |
| Year of Publication | :
0
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| Journal | :
PloS one
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| Volume | :
9
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| Issue | :
3
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| Number of Pages | :
e89621
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| Date Published | :
2014
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| URL | :
https://dx.plos.org/10.1371/journal.pone.0089621
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| DOI | :
10.1371/journal.pone.0089621
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| Short Title | :
PLoS One
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| Download citation |