Inhibitors of CTP biosynthesis potentiate the anti-human immunodeficiency virus type 1 activity of 3TC in activated peripheral blood mononuclear cells.
| Author | |
|---|---|
| Abstract | :
Unlike hydroxyurea, the CTP synthetase inhibitor acivicin and, to a lesser extent, two other inhibitors of CTP synthesis, increased the phosphorylation and anti-HIV-1 activity of 3TC in PHA-P-activated PBMC. These data suggest that to improve the antiretroviral activity of 3TC, it may be worth focusing on inhibition of CTP synthesis. |
| Year of Publication | :
2004
|
| Journal | :
Antiviral research
|
| Volume | :
61
|
| Issue | :
1
|
| Number of Pages | :
67-70
|
| ISSN Number | :
0166-3542
|
| URL | :
https://linkinghub.elsevier.com/retrieve/pii/S0166354203001840
|
| DOI | :
10.1016/j.antiviral.2003.08.002
|
| Short Title | :
Antiviral Res
|
| Download citation |