Joel Rosenthal

Department of Chemistry and Biochemistry,

University of Delaware, Newark, DE, 19716

 

Abstract: Development of new electrosynthetic tools and methods has attracted much interest

in recent years as a means to prepare chemicals and materials that are either

inaccessible or whose preparation is inefficient using traditional thermal chemistries. In

addition to opening up routes to new compounds and materials, implementation of

electrosynthetic strategies can enable reduced waste streams and more streamlined

synthetic routes, while circumventing the use of expensive, acutely toxic, and highly

reactive reagents. Driving synthetic chemistry with electric current as opposed to heat

also represents a direct way to power chemical processes using renewable energy (such

as electricity from wind or sunlight), and therefore provides an opportunity for more

sustainable chemical syntheses and renewable energy storage.

Our lab has developed efficient electrosynthetic routes to prepare commodity

chemicals and fuels, fine chemicals, and new inorganic materials. In this presentation, we

will provide an overview of our efforts in each of these areas, which include 1) controlling

the electrochemical reduction of carbon dioxide to switch between the formation of either

formic acid or carbon monoxide depending on the electrolysis conditions; 2) the

electrosynthesis of α,β-ynones en route to polyphenols that show anti-cancer and anti-

HIV activity; and 3) the electrochemical synthesis of new classes of metal-organic

frameworks and other porous materials that are based upon non-traditional metal ions

and organic linkers. Throughout the presentation, we will show how the ability to drive

challenging transformations that require the activation of strong bonds or access to highly

reactive chemical intermediates is greatly facilitated through an electrochemical

approach. We will also demonstrate how controlling the chemical dynamics and

environments at working electrode interfaces can be leveraged to promote interesting

energy conversion processes, solar fuel generation, and porous material construction.

Implications for the future development of efficient electrosynthetic strategies and

platforms will also be discussed.