Yinan Wei

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  • Professor of Chemistry
  • Director of Graduate Studies
  • Chemistry
  • Biological
235 Chemistry-Physics Building

Ph.D. Princeton University, 2003

Graduate Training
Biological Chemistry
PubMed Publications*: 
  • Yang, L.;Shi, H ;Zhang, L.;Lin, X.;Wei, Y ;Jiang, H.;Zeng, Z. "Emergence of two AcrB substitutions conferring multidrug resistance to <i>Salmonella spp</i>." Antimicrobial agents and chemotherapy (2021): Details. Full text
  • Zhang, Y.;Cui, J ;Zhang, G ;Wu, C.;Abdel-Latif, A ;Smyth, SS ;Shiroishi, T ;Mackman, N ;Wei, Y ;Tao, M ;Li, Z "Inflammasome activation promotes venous thrombosis through pyroptosis." Blood advances 5, 12 (2021): 2619-2623. Details. Full text
  • Alegun, O ;Pandeya, A ;Cui, J ;Ojo, I ;Wei, Y "Donnan Potential across the Outer Membrane of Gram-Negative Bacteria and Its Effect on the Permeability of Antibiotics." Antibiotics (Basel, Switzerland) 10, 6 (2021): Details. Full text
  • Rajapaksha, P ;Ojo, I ;Yang, L.;Pandeya, A ;Abeywansha, T ;Wei, Y "Insight into the AcrAB-TolC Complex Assembly Process Learned from Competition Studies." Antibiotics (Basel, Switzerland) 10, 7 (2021): Details. Full text
  • Li, Y.;Lin, X.;Hu, J ;Shuai, J ;Wei, Y ;He, D "Synthesis and biological evaluation of stilbene-based peptoid mimics against the phytopathogenic bacterium Xanthomonas citri pv. citri." Pest management science 77, 1 (2021): 343-353. Details. Full text
  • Rajapaksha, P ;Pandeya, A ;Wei, Y "Probing the Dynamics of AcrB Through Disulfide Bond Formation." ACS omega 5, 34 (2020): 21844-21852. Details.
  • Pandeya, A ;Alegun, O ;Cai, Y ;Wei, Y "Distribution of fluoroquinolones in the two aqueous compartments of <i>Escherichia coli</i>." Biochemistry and biophysics reports 24, (2020): 100849. Details. Full text
  • Pandeya, A ;Ojo, I ;Alegun, O ;Wei, Y "Periplasmic Targets for the Development of Effective Antimicrobials against Gram-Negative Bacteria." ACS infectious diseases 6, 9 (2020): 2337-2354. Details. Full text
  • Wagh, P ;Zhang, X.;Blood, R ;Kekenes-Huskey, PM ;Rajapaksha, P ;Wei, Y ;Escobar, IC "Increasing Salt Rejection of Polybenzimidazole Nanofiltration Membranes via the Addition of Immobilized and Aligned Aquaporins." Processes (Basel, Switzerland) 7, 2 (2019): Details.
  • Pandeya, A ;Li, L.;Li, Z ;Wei, Y "Gasdermin D (GSDMD) as a new target for the treatment of infection." MedChemComm 10, 5 (2019): 660-667. Details. Full text
  • Wu, C.;Lu, W ;Zhang, Y.;Zhang, G ;Shi, X ;Hisada, Y ;Grover, SP ;Zhang, X.;Li, L.;Xiang, B ;Shi, J.;Li, XA ;Daugherty, A ;Smyth, SS ;Kirchhofer, D ;Shiroishi, T ;Shao, F ;Mackman, N ;Wei, Y ;Li, Z "Inflammasome Activation Triggers Blood Clotting and Host Death through Pyroptosis." Immunity 50, 6 (2019): 1401-1411.e4. Details. Full text
  • Cai, Y ;Wilkop, T ;Wei, Y "Data on spectrum-based fluorescence resonance energy transfer measurement of <i>E. coli</i> multidrug transporter AcrB." Data in brief 21, (2018): 1649-1653. Details. Full text
  • Wang, Z.;Lu, W ;Rajapaksha, P ;Wilkop, T ;Cai, Y ;Wei, Y "Comparison of in vitro and in vivo oligomeric states of a wild type and mutant trimeric inner membrane multidrug transporter." Biochemistry and biophysics reports 16, (2018): 122-129. Details. Full text
  • Abeywansha, T ;Chai, Q ;Zhang, X.;Wang, Z.;Wei, Y "Accessibility from the Cytoplasm Is Critical for ssrA Tag-Mediated Degradation of Integral Membrane Proteins by ClpXP Protease." Biochemistry 57, 38 (2018): 5602-5608. Details. Full text
  • Sun, X.;Li, D ;Wang, Z.;Yin, P ;Hu, R ;Li, H.;Liu, Q.;Gao, Y.;Ren, B ;Zheng, J.;Wei, Y ;Liu, T. "Role of Protein Charge Density on Hepatitis B Virus Capsid Formation." ACS omega 3, 4 (2018): 4384-4391. Details.
  • Piao, Z ;Wang, W.;Wei, Y ;Zonta, F ;Wan, C ;Bai, J.;Wu, S ;Wang, X.;Fang, J "Characterization of an acetohydroxy acid synthase mutant conferring tolerance to imidazolinone herbicides in rice (Oryza sativa)." Planta 247, 3 (2018): 693-703. Details. Full text
  • Zhang, X.;Lu, W ;Kwan, K ;Bhattacharyya, D ;Wei, Y "Dual-Functional-Tag-Facilitated Protein Labeling and Immobilization." ACS omega 2, 2 (2017): 522-528. Details.
  • Chai, Q ;Wang, Z.;Dutch, RE ;Wei, Y "Study of the degradation of a multidrug transporter using a non-radioactive pulse chase method." Analytical and bioanalytical chemistry 408, 27 (2016): 7745-7751. Details. Full text
  • Chai, Q ;Wang, Z.;Dutch, RE ;Wei, Y "The ssrA-Tag Facilitated Degradation of an Integral Membrane Protein." Biochemistry 55, 16 (2016): 2301-4. Details. Full text
  • Gajadeera, CS ;Zhang, X.;Wei, Y ;Tsodikov, OV "Structure of inorganic pyrophosphatase from Staphylococcus aureus reveals conformational flexibility of the active site." Journal of structural biology 189, 2 (2015): 81-6. Details. Full text
  • Wang, Z.;Ye, C ;Zhang, X.;Wei, Y "Cysteine residue is not essential for CPM protein thermal-stability assay." Analytical and bioanalytical chemistry 407, 13 (2015): 3683-91. Details. Full text
  • Ye, C ;Wang, Z.;Lu, W ;Zhong, M ;Chai, Q ;Wei, Y "Correlation between AcrB trimer association affinity and efflux activity." Biochemistry 53, 23 (2014): 3738-46. Details. Full text
  • Ye, C ;Wang, Z.;Lu, W ;Wei, Y "Unfolding study of a trimeric membrane protein AcrB." Protein science : a publication of the Protein Society 23, 7 (2014): 897-905. Details. Full text
  • Chai, Q ;Ferrell, B ;Zhong, M ;Zhang, X.;Ye, C ;Wei, Y "Diverse sequences are functional at the C-terminus of the E. coli periplasmic chaperone SurA." Protein engineering, design & selection : PEDS 27, 4 (2014): 111-6. Details. Full text
  • Yu, L.;Lu, W ;Ye, C ;Wang, Z.;Zhong, M ;Chai, Q ;Sheetz, M ;Wei, Y "Role of a conserved residue R780 in Escherichia coli multidrug transporter AcrB." Biochemistry 52, 39 (2013): 6790-6. Details. Full text
  • Zhong, M ;Ferrell, B ;Lu, W ;Chai, Q ;Wei, Y "Insights into the function and structural flexibility of the periplasmic molecular chaperone SurA." Journal of bacteriology 195, 5 (2013): 1061-7. Details. Full text
  • Ye, C ;Chai, Q ;Zhong, M ;Wei, Y "Effect of crowding by Ficolls on OmpA and OmpT refolding and membrane insertion." Protein science : a publication of the Protein Society 22, 2 (2013): 239-45. Details. Full text
  • Baker, NA ;Karounos, M ;English, V ;Fang, J ;Wei, Y ;Stromberg, A ;Sunkara, M ;Morris, AJ ;Swanson, HI ;Cassis, LA "Coplanar polychlorinated biphenyls impair glucose homeostasis in lean C57BL/6 mice and mitigate beneficial effects of weight loss on glucose homeostasis in obese mice." Environmental health perspectives 121, 1 (2013): 105-10. Details. Full text
  • Fang, J ;Yu, L.;Wu, M ;Wei, Y "Dissecting the function of a protruding loop in AcrB trimerization." Journal of biomolecular structure & dynamics 31, 4 (2013): 385-92. Details.
  • Yewle, JN ;Wei, Y ;Puleo, DA ;Daunert, S ;Bachas, LG "Oriented immobilization of proteins on hydroxyapatite surface using bifunctional bisphosphonates as linkers." Biomacromolecules 13, 6 (2012): 1742-9. Details. Full text
  • Nehru, N ;Donev, EU ;Huda, GM ;Yu, L.;Wei, Y ;Hastings, JT "Differentiating surface and bulk interactions using localized surface plasmon resonances of gold nanorods." Optics express 20, 7 (2012): 6905-14. Details. Full text
  • Geng, S ;Fang, J ;Turner, KB ;Daunert, S ;Wei, Y "Accumulation and efflux of polychlorinated biphenyls in Escherichia coli." Analytical and bioanalytical chemistry 403, 8 (2012): 2403-9. Details. Full text
  • Lu, W ;Chai, Q ;Zhong, M ;Yu, L.;Fang, J ;Wang, T.;Li, H.;Zhu, H.;Wei, Y "Assembling of AcrB trimer in cell membrane." Journal of molecular biology 423, 1 (2012): 123-34. Details. Full text
  • Fang, J ;Wei, Y "Expression, purification and characterization of the Escherichia coli integral membrane protein YajC." Protein and peptide letters 18, 6 (2011): 601-8. Details. Full text
  • Lu, W ;Zhong, M ;Wei, Y "Folding of AcrB Subunit Precedes Trimerization." Journal of molecular biology 411, 1 (2011): 264-74. Details. Full text
  • Lu, W ;Zhong, M ;Wei, Y "A reporter platform for the monitoring of in vivo conformational changes in AcrB." Protein and peptide letters 18, 9 (2011): 863-71. Details.
  • Fang, J ;Zhang, X.;Cai, Y ;Wei, Y "Small globular protein motif forms particulate hydrogel under various pH conditions." Biomacromolecules 12, 5 (2011): 1578-84. Details. Full text
  • Yu, L.;Zhong, M ;Wei, Y "Direct fluorescence polarization assay for the detection of glycopeptide antibiotics." Analytical chemistry 82, 16 (2010): 7044-8. Details. Full text
  • Zhong, M ;Fang, J ;Wei, Y "Site specific and reversible protein immobilization facilitated by a DNA binding fusion tag." Bioconjugate chemistry 21, 7 (2010): 1177-82. Details. Full text
  • Wei, Y ;Daunert, S "Enabling technologies in discovery: the 2009 Nobel Prize and its implications in antibiotic design." Analytical and bioanalytical chemistry 396, 5 (2010): 1623-6. Details. Full text
  • Fang, J ;Yu, L.;Gao, P ;Cai, Y ;Wei, Y "Detection of protein-DNA interaction and regulation using gold nanoparticles." Analytical biochemistry 399, 2 (2010): 262-7. Details. Full text
  • Bachas-Daunert, PG ;Sellers, ZP ;Wei, Y "Detection of halogenated organic compounds using immobilized thermophilic dehalogenase." Analytical and bioanalytical chemistry 395, 4 (2009): 1173-8. Details. Full text
  • Ehrick, JD ;Luckett, MR ;Khatwani, S ;Wei, Y ;Deo, SK ;Bachas, LG ;Daunert, S "Glucose responsive hydrogel networks based on protein recognition." Macromolecular bioscience 9, 9 (2009): 864-8. Details. Full text
  • Yu, L.;Fang, J ;Wei, Y "Characterization of the ligand and DNA binding properties of a putative archaeal regulator ST1710." Biochemistry 48, 10 (2009): 2099-108. Details. Full text
  • HernĂ¡ndez, S ;Porter, C ;Zhang, X.;Wei, Y ;Bhattacharyya, D "Layer-by-layer Assembled Membranes with Immobilized Porins." RSC advances 7, 88 (0): 56123-56136. Details.
  • Lu, W ;Zhong, M ;Chai, Q ;Wang, Z.;Yu, L.;Wei, Y "Functional relevance of AcrB Trimerization in pump assembly and substrate binding." PloS one 9, 2 (0): e89143. Details. Full text
  • Yu, L.;Lu, W ;Wei, Y "AcrB trimer stability and efflux activity, insight from mutagenesis studies." PloS one 6, 12 (0): e28390. Details. Full text
  • Wang, Z.;Li, C.;Wei, Y "Application of Fluorescence in Studying Therapeutic Enzymes." Advances in experimental medicine and biology 1148, (0): 105-114. Details. Full text
  • Hamorsky, Teasley ;Ensor, CM ;Wei, Y ;Daunert, S "A bioluminescent molecular switch for glucose." Angewandte Chemie (International ed. in English) 47, 20 (0): 3718-21. Details. Full text
  • Wang, Z.;Zhong, M ;Lu, W ;Chai, Q ;Wei, Y "Repressive mutations restore function-loss caused by the disruption of trimerization in Escherichia coli multidrug transporter AcrB." Frontiers in microbiology 6, (0): 4. Details. Full text
* Publications are automatically pulled from pubmed.gov based on a user-specific query. Results may include incorrect citations. See: Tutorial on improving PubMed results.
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