Dmytro Havrylyuk

dyha223's picture
  • Research Faculty
  • Chemistry
dyha223@uky.edu
CP-148A
859-576-2162
Education

Ph.D. Danylo Halytsky Lviv National Medical University (DH LNMU), Lviv, Ukraine, 2007

Research

Medicinal chemistry, organic and inorganic synthesis

Graduate Training

Pharmacy

Selected Publications: 

Selected publications prior to UK:

1. Havrylyuk D., Zimenkovsky B., Lesyk R. Synthesis, biological activity of thiazolidinones bearing indoline moiety and isatin based hybrids. Mini-Reviews in Organic Chemistry, 2015, 12, 66-87.

2. Havrylyuk D., Zimenkovsky B., Karpenko O., Grellier P., Lesyk R. Synthesis of pyrazoline-thiazolidinone hybrids with trypanocidal activity. European Journal of Medicinal Chemistry, 2014, 85, 245-254.

3. Avdieiev S., Gera L., Hodges R.S., Havrylyuk D., Lesyk R., Ribrag V., Vassetzky Y., Kavsan V. Bradykinin antagonists and thiazolidinone derivatives as new potential anti-cancer compounds. Bioorganic & Medicinal Chemistry. 2014, 22, 3815–3823. 4

4. Havrylyuk D., Zimenkovsky B., Vasylenko O., Lesyk R. Synthesis, anticancer and antiviral activity of new 2- pyrazoline substituted 4-thiazolidinones. J. Heterocyclic Chem. 2013, 50, E55-E62.

5. Havrylyuk D., Zimenkovsky B., Vasylenko O., Day C.W., Smee D.F., Grellier P., Lesyk R. Synthesis and biological activity evaluation of 5-pyrazoline substituted 4-thiazolidinones. European Journal of Medicinal Chemistry. 2013, 66, 228-237.

6. Havrylyuk D., Zimenkovsky B., Vasylenko O., Gzella A., Lesyk R. Synthesis of new 4-thiazolidinone, pyrazoline, and isatin-based conjugates with promising antitumor activity. J. Med. Chem. 2012, 55, 8630−8641.

7. Havrylyuk D., Kovach N.,Zimenkovsky B., Vasylenko O.,Lesyk R. Synthesis and anticancer activity of isatin-based pyrazolines and thiazolidines conjugates. Arch. Pharm. Chem. LifeSci. 2011, 344, 514–522.

8. Havrylyuk D., Mosula L., Zimenkovsky B., Vasylenko O., Gzella A., Lesyk R. Synthesis and anticancer activity evaluation of 4-thiazolidinones containing benzothiazole moiety. European Journal of Medicinal Chemistry. 2010, 45, 5012-5021.

9. Havrylyuk D., Zimenkovsky B., Vasylenko O., Zaprutko L., Gzella A., Lesyk R. Synthesis of novel thiazolone-based compounds containing pyrazoline moiety and evaluation of their anticancer activity. European Journal of Medicinal Chemistry, 2009, 44(4), 1396-1404.

PubMed Publications*: 
  • Havrylyuk, D ;Howerton, BS ;Nease, L ;Parkin, S.;Heidary, DK ;Glazer, EC "Structure-activity relationships of anticancer ruthenium(II) complexes with substituted hydroxyquinolines." European journal of medicinal chemistry 156, (2018): 790-799. Details. Full text
  • Havrylyuk, D ;Heidary, DK ;Nease, L ;Parkin, S.;Glazer, EC "Photochemical Properties and Structure-Activity Relationships of Ru<sup>II</sup> Complexes with Pyridylbenzazole Ligands as Promising Anticancer Agents." European journal of inorganic chemistry 2017, 12 (2017): 1687-1694. Details.
  • Havrylyuk, D ;Roman, O ;Lesyk, R "Synthetic approaches, structure activity relationship and biological applications for pharmacologically attractive pyrazole/pyrazoline-thiazolidine-based hybrids." European journal of medicinal chemistry 113, (2016): 145-66. Details. Full text
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