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[(-unsaturated)-232.7(aldehydes)]TJ
-16.37 -1.2266 TD
[(formed)-307.9(during)-307.3(the)-300.9(peroxidation)-307.6(of)-306.7(polyunsaturated)-307.6(fatty)-308.8(ac-)]TJ
0 -1.2203 TD
[(ids)-292.4(\(384\).)-286.9(PCO)-282.8(are)-291(also)-285.3(formed)-288.9(by)-287(the)-288.3(secondary)-286.2(reactions)-289.1(of)]TJ
T*
[(amino)-228.1(groups)-226.9(of)-224.5(lysine)-224.7(residues)-232.3(with)-224(reducing)-224.2(sugars)-229.9(or)-224.8(their)]TJ
T*
[(oxidation)-817.8(production)-821.6(\(glycation/glycoxidation)-822.7(reactions\))]TJ
0 -1.2266 TD
[(\(114,)-273.8(352\).)-267.5(Hence,)-270.9(protein)-271.4(carbonylation)-268(leads)-272.8(to)-268.8(oxidation)-267.7(of)]TJ
0 -1.2203 TD
[(side-chains,)-293.4(backbone)-283.7(fragmentation,)-290.9(formation)-289.4(of)-281.4(new)-289.4(reac-)]TJ
T*
[(tive)-440.9(species)-442.9(\(peroxides,)-441.7(DOPA\),)-440.5(release)-434.7(of)-439.5(further)-443.3(radicals,)]TJ
0 -1.2266 TD
[(and)-492.8(occurrence)-487.1(of)-490.1(chain)-483.3(reactions.)-494.3(Most)-483.9(oxidative)-489.8(protein)]TJ
0 -1.2203 TD
[(damage)-402.3(is)-403.2(irreversible;)-407.5(however,)-404(there)-402.7(are)-404.8(certain)-405.1(enzymes)]TJ
/F5 1 Tf
T*
[(in)-189.7(vivo)]TJ
/F4 1 Tf
2.9085 0 TD
[(that)-193.5(can)-185.5(either)-191.2(repair)-189.1(or)-193.2(clear)-186.3(the)-193.4(damaged)-184(proteins)-196.8(\(see)]TJ
-2.9085 -1.2266 TD
[(below\).)-401.3(PCO)-402.9(are)-398.5(stable)-394.8(products)-402.3(of)-401.6(protein)-404.1(oxidation)-400.5(com-)]TJ
0 -1.2203 TD
[(pared)-434.4(with)-439(the)-433.7(other)-437.2(products)-433.9(of)-433.2(OS,)-434.4(for)-433.9(example,)-436.8(F2)-433.9(iso-)]TJ
T*
[(prostanes,)-778.7(which)-770(are)-765.2(readily)-773.3(generated)-769.9(during)-768.8(sample)]TJ
0 -1.2266 TD
[(storage,)-378.7(processing,)-381.3(and)-379(analysis.)-379.8(Consequently,)-382(PCO)-371.3(are)-379.5(a)]TJ
0 -1.2203 TD
[(general)-454(and)-442.2(widely)-452.3(used)-448.2(index)-448.3(to)-445.8(determine)-451(the)-446.4(extent)-448.9(of)]TJ
T*
[(oxidative)-300.2(modication)-303.4(in)-297.8(both)]TJ
/F5 1 Tf
13.6701 0 TD
[(in)-297.2(vivo)]TJ
/F4 1 Tf
3.1235 0 TD
(and)Tj
/F5 1 Tf
1.9727 0 TD
[(in)-297.2(vitro)]TJ
/F4 1 Tf
3.3322 0 TD
(conditions)Tj
-22.0986 -1.2203 TD
[(\(40,)-514.6(79,)-507.8(114,)-507.3(352,)-513.6(360,)-507.3(401\).)-514.1(Several)-508.6(sensitive)-513.6(assays)-513.2(were)]TJ
ET
q
420.92 0 0 317.877 96.775 414.368 cm
/Im1 Do
Q
BT
/F9 1 Tf
8.9663 0 0 8.9663 62.022 397.5873 Tm
[(FIG.)-273.6(1.)-1001.4(Free)-276(radicals)-274.1(are)-277.9(generated)-275.2(by)-273(various)-277.4(mechanisms.)]TJ
/F4 1 Tf
27.6311 0 TD
[(One)-271.9(way)-277.4(by)-274.4(which)-276.8(free)-272.9(radicals)-276(are)-278.3(generated)-276.7(is)]TJ
/F5 1 Tf
21.422 0 TD
(via)Tj
/F4 1 Tf
1.4796 0 TD
[(release)-276.6(of)]TJ
-50.5327 -1.1128 TD
[(superoxide)-243.6(anion)-233.9(from)-241.8(the)-237.7(mitochondria,)-237.8(leading)-238.6(to)-237.2(increased)-238.2(formation)-238.8(of)-243.5(reactive)-238(oxygen)-238.4(and)-233.5(reactive)-238(nitrogen)-246.2(species)-234.2(and,)]TJ
0 -1.1065 TD
[(consequently,)-349.5(damaging)-337.8(the)-345.2(biomolecules.)-345.3(\(To)-341.4(see)-342.5(this)-343.8(illustration)-346.6(in)-342(color)-337.9(the)-345.2(reader)-345.1(is)-340(referred)-346.7(to)-338.4(the)-345.2(web)-341.1(version)-341.1(of)-344.7(this)]TJ
0 -1.1128 TD
[(article)-335.7(at)-335.1(www.liebertonline.com/ars.\))]TJ
/F3 1 Tf
0 42.5975 TD
(1612)Tj
44.1592 0 TD
[(BUTTERFIELD)-336.7(ET)-338.7(AL.)]TJ
ET
endstream
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