The Chemistry-Physics building is at the corner of Rose Street and Funkhouser Drive on the main campus of the University of Kentucky in Lexington.
From the north or west:
Take I-75 south or I-64 east until they merge. Take the first exit after the merge (Exit 115, Newtown Pike, Rte 922) and turn right onto Newtown Pike. Stay on Newtown Pike until West Main Street (several miles; you are close when you pass over railroad tracks), and turn left. Main St. shortly divides into two one-way streets; the direction you will be going is now called Vine St. The third right after the Vine-Main divide is Upper Street; turn right. The parking garage is on your left shortly after the third traffic light.
From the southwest:
From I-65 north, take the Bluegrass Parkway until it merges into US 60. Go east on US 60 toward Lexington. It is now called Versailles Road. You will pass underneath KY 4 (New Circle Road), through a commercial area, through a residential area, and then through an industrial area. You will pass over a railroad bridge, and the road will curve to the right, become one-way, and change its name to West Maxwell Street. After you cross Broadway (there is a traffic light), take the second right, onto Upper Street (there is another traffic light). The parking garage is on your left shortly after the first traffic light.
From the south:
Take I-75 north to the first Lexington exit (Exit 104, Athens-Boonesboro Road), and turn left. After a few miles you will enter a highly commercial district. Continue on what is now Richmond Road to New Circle Road (Rte 4). The entrance to New Circle Road going west is a left turn just past the New Circle Road overpass. Take New Circle Road west three exits to Nicholasville Road. Turn right onto Nicholasville Road, and go about five miles, passing the Central Baptist Hospital, the Equine Hospital, the Tobacco Research Institute, and the Kentucky Clinic. After you pass under the first pedestrian overpass, count three traffic lights. The road then widens and becomes one-way, and you will need to move all the way to the left. Immediately after the second pedestrian overpass, turn left into the parking garage. If you miss the turn into the garage, turn left onto Winslow Street, then left onto Upper Street, and enter the garage from Upper Street.
From the east:
Take I-64 west to just short of Lexington, where you will take the left exit to I-75 south. Take the first exit to US 60, and make a right onto US 60 west (Winchester Road), heading into Lexington. You will pass over New Circle Road. Continue straight into town. At one point you will need to bear left (ca. 11:00) to stay on US 60. Not long after this you will reach the intersection with Main Street, where you will be unable to continue to go straight because the road ahead is one-way against you. (There will be some horse statues in a small park on the right.) Turn right onto Main Street, which is also US 421 north and perhaps still US 60 west and is one-way at this point. Turn left at Upper Street, the third street past the Kentucky Theatre. The parking garage is on your left shortly after the fourth traffic light.